Hans Gühring

Efficacy and safety of enpatoran, a Toll-like receptor 7/8 inhibitor, in patients with skin manifestations of cutaneous lupus erythematosus or systemic lupus erythematosus: findings from Cohort A of a multicentre, international, double-blind, placebo-controlled, dose-finding phase 2 trial

Eric F Morand, Victoria P Werth, Joerg Wenzel, Richard Furie et autres

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Enpatoran, a Toll-like receptor 7/8 inhibitor, in moderate-to-severe systemic lupus erythematosus: findings from Cohort B of a multicentre, international, double-blind, placebo-controlled dose-finding phase 2 trial

Eric F Morand, Maria Dall’Era, Jorge Sanchez-Guerrero, David R. Pearson et autres

BACKGROUND: Toll-like receptors (TLR) 7 and 8 (TLR7/8) are activators of innate and adaptive immunity contributing to lupus pathogenesis. In Cohort B of WILLOW, a phase 2, randomised, placebo-controlled, double-blind, basket, dose-finding study, enpatoran, an oral small molecule inhibitor of TLR7/8, was …

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S1:04 Enpatoran, a toll-like receptor 7/8 inhibitor, in skin manifestations of cutaneous lupus erythematosus or systemic lupus erythematosus: pooled safety data from the phase 2 willow trial

Eric F Morand, Victoria P Werth, Richard Furie, Sanjeev Roy et autres

Objectives Cutaneous manifestations of lupus are common, yet effective therapies targeting the underlying pathogenesis are lacking. Toll-like receptors (TLR) 7/8 are key upstream drivers of the interferon pathway and neutrophil, myeloid cell and B cell activation. Enpatoran is a novel, first-in-class, oral …

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PO:11:286 Design of a phase 3, randomised, double-blind, placebo-controlled parallel study to evaluate the efficacy and safety of enpatoran in cutaneous manifestations of lupus with or without systemic disease

Eric F Morand, J Michelle Kahlenberg, Benjamin F. Chong, Edward M J Vital et autres

Objectives There are no approved therapies for cutaneous manifestations of lupus, which occur in isolation (cutaneous lupus erythematosus [CLE]) or as a manifestation of systemic lupus erythematosus (SLE). Toll-like receptors (TLR)7/8 are key upstream drivers of type I interferon (IFN) pathway activation …

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LB0004 RANDOMISED, PLACEBO-CONTROLLED PHASE II STUDY OF ORAL ENPATORAN, A FIRST-IN-CLASS TOLL-LIKE RECEPTOR 7/8 INHIBITOR, IN SYSTEMIC LUPUS ERYTHEMATOSUS

Eric Francis Morand, Maria Dall’Era, Jorge Sánchez‐Guerrero, Dess Pearson et autres

Background: Current treatments for lupus (including systemic lupus erythematosus [SLE] and cutaneous lupus erythematosus [CLE]) offer inadequate disease control and may be associated with cumulative toxicity. Toll-like receptors (TLR) 7 and TLR8 have functions in innate and adaptive immunity implicated in SLE …

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RANDOMIZED, PLACEBO-CONTROLLED PHASE II STUDY OF ENPATORAN, A SMALL MOLECULE TOLL-LIKE RECEPTOR 7/8 INHIBITOR, IN CUTANEOUS LUPUS ERYTHEMATOSUS: RESULTS FROM COHORT A

David R. Pearson, Eric Francis Morand, Joerg Wenzel, Richard Alan Furie et autres

O010 / #827 Topic: AS07 - Cutaneous Lupus Late-Breaking Abstract ABSTRACT CONCURRENT SESSION 01: FINDINGS FROM LUPUS CLINICAL TRIALS 22-05-2025 1:40 PM - 2:40 PM Background/Purpose No treatment is approved for cutaneous lupus erythematosus (CLE), which may occur in the presence or …

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Antibody response to SARS-CoV-2 vaccines in patients with relapsing multiple sclerosis treated with evobrutinib: A Bruton’s tyrosine kinase inhibitor

Amit Bar‐Or, Anne Haney Cross, Anthony Lawrence Cunningham, Yann Hyvert et autres

Background: Evobrutinib is an oral, central nervous system (CNS)-penetrant and highly selective covalent Bruton’s tyrosine kinase inhibitor under clinical development for patients with relapsing multiple sclerosis (RMS). Objective: To investigate the effect of evobrutinib on immune responses in severe acute respiratory syndrome …

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R399E , A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis

Anne Gigout, Daniela Werkmann, Stephanie Menges, Christian Brenneis et autres

OBJECTIVE: To preclinically characterize a mutant form of growth and differentiation factor 5, R399E, with reduced osteogenic properties as a potential disease-modifying osteoarthritis (OA) drug. METHODS: Cartilage, synovium, and meniscus samples from patients with OA were used to evaluate anabolic and antiinflammatory …

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Randomized Phase II JANUS Study of Atacicept in Patients With IgA Nephropathy and Persistent Proteinuria

Jonathan Barratt, James Alan Tumlin, Yusuke Suzuki, Amy H. Kao et autres

Introduction Patients with IgA nephropathy (IgAN) and persistent proteinuria are at risk of progression to kidney failure. Atacicept is a novel B-cell–targeted immunomodulator, shown to reduce immunoglobulin levels in patients with autoimmune diseases. Methods JANUS (NCT02808429) was a phase II study that …

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OP0189 ASSESSMENT OF CARTILAGE DEGRADATION AND PROTECTIVE MARKERS IN SYNOVIAL FLUID FROM OSTEOARTHRITIS PATIENTS BEFORE AND AFTER CYCLES OF INTRA-ARTICULAR INJECTIONS WITH SPRIFERMIN

Anne‐Christine Bay‐Jensen, Angela A. Manginelli, Flavie Moreau, Yi He et autres

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FRI0404 SEPERATION OF HIGH AND LOW RESPONSE GROUPS IN OSTEOARTHRITIS USING SERUM CARTILAGE DEGRADATION AND FORMATION MARKERS – A 3 YEAR FOLLOW-UP ON THE FORWARD STUDY TESTING THE EFFICACY OF SPRIFERMIN

Hans Gühring, Anne‐Christine Bay‐Jensen, Flavie Moreau, J.R. Andersen et autres

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Importance of Osmolarity and Oxygen Tension for Cartilage Tissue Engineering

Stefan Sieber, Martin Michaelis, Hans Gühring, S. Lindemann et autres

For cartilage repair in vivo or evaluation of new therapeutic approaches in vitro, the generation of functional cartilage tissue is of crucial importance and can only be achieved if the phenotype of the chondrocytes is preserved. Three-dimensional (3D) cell culture is broadly …

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