Gözde Balkaya Aykut

Real-World Outcomes of Second-Line Chemotherapy in Metastatic Urothelial Carcinoma

İlkay Çıtakkul, Hayati Arvas, Mert Karaoğlan, Bahadır Köylü et autres

Second-line chemotherapy is widely used in metastatic urothelial carcinoma after progression on first-line platinum-based therapy, but its independent contribution to survival, as opposed to selection of healthier patients, remains unclear. In this multicenter retrospective cohort of 142 patients treated with first-line platinum-based …

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Revisiting Platinum Sensitivity in Relapsed Small-Cell Lung Cancer: Outcomes of Platinum-Containing Doublet Chemotherapy in the 3–6 Month Relapse Window

İbrahim Çil, Maral Martin Mıldanoğlu, Yasin Kutlu, Ali Kaan Güren et autres

Background: Second-line treatment selection in relapsed extensive-stage small-cell lung cancer (ES-SCLC) is commonly guided by the platinum-free interval, but the optimal approach for patients progressing 3–6 months after first-line platinum-based therapy remains uncertain. We compared platinum-containing doublet chemotherapy with single-agent chemotherapy in …

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Maintenance pemetrexed after platinum pemetrexed chemotherapy and survival outcomes in malignant pleural mesothelioma in a multicenter real world study

Okan Aydın, Zehra Sucuoğlu İşleyen, Mert Erciyestepe, Ahmet Emin Ozturk et autres

Malignant pleural mesothelioma (MPM) is an aggressive malignancy with poor prognosis, and the role of maintenance therapy after first-line platinum-pemetrexed chemotherapy remains unclear. We conducted a multicenter retrospective study including 96 patients with metastatic or unresectable MPM treated across eight tertiary oncology …

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Prognostic Impact of Ectopic Fat Deposition Within the Psoas Muscle in Patients with Stage IV Pancreatic Cancer Receiving Systemic Chemotherapy

İbrahim Çil, Ilker Nihat Ökten, Zeynep Nihal Kazcı, Ayberk Bayramgil et autres

Background: Computed tomography-based body composition parameters are emerging prognostic markers in pancreatic cancer. While sarcopenia and myosteatosis have been widely studied, the prognostic significance of ectopic fat deposition within the psoas muscle remains unclear. We aimed to evaluate the prognostic impact of …

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Meme Kanseri

Semra Taş, Ali Alper Solmaz, Burçin Çakan Demirel, Esra Zeynelgil et autres

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Duktal Karsinoma İn Situ

Gözde Balkaya Aykut

Duktal karsinoma in situ (DKİS), meme duktal - lobüler ünitesinde bazal membranı aşmadan sınırlı kalan, farklı histopatolojik özellikler sergileyebilen heterojen bir neoplastik proliferasyondur. Mamografinin yaygın kullanımıyla birlikte DKİS insidansında belirgin bir artış gözlenmiş ve günümüzde yeni teşhis edilen meme kanserlerinin yaklaşık dörtte …

Prognostic Value of Inflammation and Nutrition-Based Scores in Non-Small Cell Lung Cancer

Mert Erciyestepe, Oğuzhan Selvi, Şermin Dinç Sonuşen, Ahmet Emin Öztürk et autres

OBJECTIVE: In studies conducted on non-small cell lung cancer (NSCLC) patients, many factors such as age, stage, weight loss, lymph node, and pleural involvement have been shown to affect survival. On the other hand, systemic inflammation plays a critical role in proliferation, …

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Nutritional status as a mediator between the age-related muscle loss and frailty in community-dwelling older adults

Filiz Demırdağ, Esma Nur Kolbaşı, Gözde Balkaya Aykut, Kübra Yıldız Güler et autres

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