Ammar Akhtar

Preprints in Cardiovascular Science: Finding the Right Balance Between Speed, Openness, and Scientific Integrity

Kashif Ali Hashmi, Abdullah Hashmi, Ammar Akhtar

Scientific publishing is undergoing a profound transformation, driven by increasing demands for rapid dissemination, transparency, and accessibility of research. Among the most influential developments is the widespread adoption of preprints—complete scientific manuscripts that are made publicly available online before undergoing formal peer …

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Global Registry of Acute Coronary Events versus Thrombolysis in Myocardial Infarction Scores for Predicting Angiographic Severity of Coronary Artery Disease in Patients With Non-ST Segment Elevation MI

Ammar Akhtar, Balawal Nazeer, Abdullah Hashmi, M. Hassan et autres

Background: The Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in MI (TIMI) scores are widely used to assess risk and help with treatment decisions in patients with non-ST-segment elevation MI (NSTEMI). Methods: Patients with NSTEMI admitted to the Department of …

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Association of Admission Hyponatremia with In-Hospital Mortality in Patients with Acute Heart Failure: A Prospective Cohort Study

Muhammad Asif Shahzad, Muhammad Sohail Saleemi, Muhammad Tahir Mohyuddin, Kashif Ali Hashmi et autres

Objectives: To determine the association between low admission serum sodium levels (hyponatremia) and in-hospital mortality among patients presenting with acute heart failure. Methodology: A total of 238 patients aged 20–60 years presenting with acute heart failure of less than seven days duration …

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Unmasking Genetic Predispositions: Factor V Leiden and the Evolving Landscape of Coronary Artery Disease in Pakistan

Kashif Ali Hashmi, Ammar Akhtar, Abdullah Hashmi

Cardiovascular disease (CVD) continues to impose a substantial burden on global health systems, with coronary artery disease (CAD) remaining the leading cause of morbidity and mortality worldwide. In Pakistan, this burden is particularly concerning, as CAD not only presents with high prevalence …

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Giant Biatrial Myxoma Presenting as Constitutional Symptoms and Bivalvular Obstruction

Ammar Akhtar, Abdullah Hashmi, Ifrah Tahir, Kashif Ali Hashmi

BACKGROUND: Simultaneous biatrial myxoma is an extremely rare form of primary cardiac tumor, which is often an acute life-threatening problem given its potential to cause simultaneous tricuspid and mitral valve obstructions. CASE SUMMARY: A 25-year-old woman presented with a history of persistent …

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Neutrophil–Lymphocyte Ratio: A Simple Marker Reflecting the Complex Biology of Myocardial Infarction

Kashif Ali Hashmi, Ammar Akhtar, Abdullah Hashmi

The association of inflammation and atherosclerosis has, for many years, now been recognized as one of the cornerstones in the pathophysiology of cardiovascular disease. In addition to cholesterol and thrombosis, the process of atherogenesis is now understood as a chronic inflammatory process …

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Diagnostic Accuracy of Wellens’ Syndrome in Predicting Significant Proximal Left Anterior Descending Artery Stenosis among Patients with Acute Coronary Syndrome

Khawaja Muhammad Mujtaba, Madiha Mohyuddin, Kashif Ali Hashmi, Faisal Ramzan et autres

Objectives: This study aimed to determine the prevalence and diagnostic accuracy of Wellens’ Syndrome in predicting significant proximal left anterior descending (LAD) artery stenosis among patients presenting with acute coronary syndrome (ACS), using coronary angiography as the gold standard. Methodology: A prospective …

Unveiling Left Main Coronary Artery Dimensions: Associations with Body Surface Area and Left Ventricular Parameters in a Pakistani Cohort Using CT-Coronary Angiography

Muhammad Zubair Zaffar, Ammar Akhtar, Roshni Minhas, Faisal Ramzan et autres

Objective: This study aimed to evaluate the dimensions of the left main coronary artery (LMCA) in a local Pakistani population and investigate their associations with body surface area (BSA), left ventricular (LV) mass, and ejection fraction (EF). Methodology: A descriptive cross-sectional study …

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Re-evaluating the Impact of Haemoglobin Levels on Outcomes in STEMI Patients Undergoing Primary PCI

Kashif Ali Hashmi, Ammar Akhtar

The recent study by Shah and colleagues, "Association of Hemoglobin Level with In-Hospital Outcomes in Patients with STEMI Treated with Primary Percutaneous Coronary Intervention," brings renewed attention to the clinical impact of anemia in patients presenting with ST-elevation myocardial infarction (STEMI) [1]. …

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Association Between Left Atrial Volume Index and Severity of Diastolic Dysfunction in Hypertensive Patients

Muhammad Tauqeer, Muhammad Sohail Saleemi, Ammar Akhtar, Faisal Ramzan et autres

Objectives: The study aimed to determine the prevalence of diastolic dysfunction (DD) in hypertensive patients and to examine the association between the Left Atrial Volume Index (LAVI) and the severity of diastolic dysfunction in these patients. Methodology: This cross-sectional study was conducted …

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Atrial Myxoma and Rheumatic Mitral Stenosis: Embolic Stroke Strikes Days Before Surgery

Hafsa Hashmi, Kashif Ali Hashmi, Ammar Akhtar, Mohammed Khattak

Cardiac myxomas are the most common primary cardiac tumors. Their primary location is the left atrium, but they can arise in any cardiac chamber. Although histologically benign, atrial myxomas are functionally malignant due to their high embolic potential, which can lead to …

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Current practice in ultrasound grading of carotid artery stenosis in the UK and Ireland

Siobhan Trochowski, Ammar Akhtar, K Bond, Anne Corby et autres

Introduction: Ultrasound is usually the first-line imaging modality in the UK and Ireland for evaluating the severity of carotid artery disease. The last UK and Ireland audit on grading of internal carotid artery (ICA) stenosis with ultrasound was reported in 2006 whilst …