Marc Niebel

Combining analysis of individual and wastewater whole genome sequencing improves SARS-CoV-2 surveillance

Evan P. Troendle, Andrew Lee, Marina Reyne, Danielle M Allen et autres

Effective pathogen surveillance is critical for public health decision-making, with both individual and environmental monitoring playing essential roles. While wastewater (WW) and individual whole genome sequencing (WGS) have been used to monitor SARS-CoV-2 dynamics, their complementary potential for enhancing national-level genomic surveillance …

gb (code pays fourni par la source)

Coxsackievirus B4 (CV-B4) linked to four severe neonatal infections including one fatal, Northern Ireland, October 2024 to February 2025

Susan Feeney, Mike Crilly, Sharon Christie, Julie Lewis et autres

We report four cases of severe neonatal non-polio enterovirus infection, requiring hospital admission. Infants presented to different regional hospitals across Northern Ireland from late 2024 to early 2025. Three had neonatal meningitis and one showed rapid demise, leading to sepsis, multi-organ failure …

gb (code pays fourni par la source)

Combining individual and wastewater whole genome sequencing improves SARS-CoV-2 surveillance

Evan P. Troendle, Andrew Lee, Marina Reyne, Danielle M Allen et autres

ABSTRACT Background Robust methods to track pathogens support public health surveillance. Both wastewater (WW) and individual whole genome sequencing (WGS) are used to assess viral variant diversity and spread. However, their relative performance and the information provided by each approach have not …

gb (code pays fourni par la source)

Hepatitis C virus diversity and treatment outcomes in Benin: a prospective cohort study

Lucrèce Ahovègbé, Rajiv Shah, Aboudou Raïmi Kpossou, Christopher Davis et autres

BACKGROUND: 10 million people are chronically infected with the hepatitis C virus (HCV) in sub-Saharan Africa. The assessment of viral genotypes and treatment response in this region is necessary to achieve the WHO target of worldwide elimination of viral hepatitis by 2030. …

Ouganda, gb, Bénin, Cameroun (code pays fourni par la source)

Mycobacterium abscessus genomic epidemiology in Northern Ireland, UK

Zoe Johnston, Mark J. Smyth, M. McClean, James McKenna et autres

Background: Mycobacterium abscessus complex are non-tuberculous environmental mycobacteria that cause a spectrum of opportunistic human disease, especially in patients with underlying respiratory conditions and the immunosuppressed. Intrinsic resistance to many antibiotics makes treatment of M. abscessus infections very challenging and transmission within …

gb (code pays fourni par la source)

Viruses associated with measles-like illnesses in Uganda

Prossy Namuwulya, Shirin Ashraf, Marc Niebel, Alfred Ssekagiri et autres

OBJECTIVES: In this study, we investigated the causes of measles-like illnesses (MLI) in the Uganda national surveillance program in order to inform diagnostic assay selection and vaccination strategies. METHODS: We used metagenomic next-generation sequencing (M-NGS) on the Illumina platform to identify viruses …

Ouganda, gb (code pays fourni par la source)

Mosquito virus diversity in Western and North-western Uganda

Martin N. Mayanja, Marc Niebel, Shirin Ashraf, Maryam N. Hardy et autres

Abstract Introduction Surveillance for mosquito borne arboviruses in Sub Saharan Africa has largely focussed on known viruses including Yellow fever virus (YFV), Rift Valley fever virus (RVFV), Chikungunya virus (CHIKV), West Nile virus (WNV) and Dengue viruses (DENV). Routine surveillance and outbreak …

gb, Ouganda (code pays fourni par la source)

Ticks; a reservoir for virus emergence at the human-livestock interface in Uganda

Stella Atim, Shirin Ashraf, Marc Niebel, Alfred Ssekagiri et autres

Abstract Background Uganda is one of the most biodiverse regions on the planet and a hotspot for virus emergence. In particular, the warm-humid lowlands favour tick population growth with the associated risk of tick-borne disease. The prevalent tick species Rhipicephalus appendiculatus, R. …

Ouganda, gb (code pays fourni par la source)

Prevalence of Crimean-Congo haemorrhagic fever in livestock following a confirmed human case in Lyantonde district, Uganda

Stella Atim, Marc Niebel, Shirin Ashraf, Patrick Vudriko et autres

BACKGROUND: Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne viral infection, characterized by haemorrhagic fever in humans and transient asymptomatic infection in animals. It is an emerging human health threat causing sporadic outbreaks in Uganda. We conducted a detailed outbreak investigation in the …

Ouganda, gb (code pays fourni par la source)

Risk factors for Crimean-Congo Haemorrhagic Fever (CCHF) virus exposure in farming communities in Uganda

Stella Atim, Shirin Ashraf, Sandra Belij‐Rammerstorfer, Anna Rose Ademun et autres

BACKGROUND: Crimean-Congo Haemorrhagic Fever (CCHF) is an emerging human-health threat causing sporadic outbreaks in livestock farming communities. However, the full extent and the risks associated with exposure of such communities has not previously been well-described. METHODS: We collected blood samples from 800 …

Ouganda, gb (code pays fourni par la source)

Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp, Dami A. Collier, Rawlings Datir, Isabella A.T.M. Ferreira et autres

gb, ch (code pays fourni par la source)

Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier, Anna De Marco, Isabella A.T.M. Ferreira, Bo Meng et autres

gb, ch, us, it (code pays fourni par la source)