Khatereh Khorsandi

Reprogramming tumor-associated macrophages in DMG/DIPG: emerging molecular and biophysical strategies

Khatereh Khorsandi, Lynne El Ghorayeb, Elton L VanNoy, Dalia Haydar

Diffuse Midline Glioma (DMG), often formerly called Diffuse Intrinsic Pontine Glioma (DIPG) when in the brainstem, DMG/DIPG is a lethal pediatric brain tumor defined by infiltrative growth, resistance to conventional therapies, and a profound immunosuppressive tumor microenvironment (TME). Tumor-associated macrophages (TAMs), including …

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237 Dual CD123/B7-H3 CAR T cell therapy reprograms the tumor microenvironment and enhances immunity in DIPG

Khatereh Khorsandi, Jaquelyn T. Zoine, Mireya Paulina Velasquez, Dalia Haydar

Background Despite promising safety profiles, B7-H3 CAR T cell therapies have yet to demonstrate meaningful clinical efficacy in diffuse intrinsic pontine glioma (DIPG), a devastating pediatric brain cancer characterized by a profoundly immunosuppressive tumor microenvironment (TME). This TME is dominated by tumor-associated …

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EXTH-114. Dual CD123 and B7-H3 CAR T Cells Potentiate Immune Responses and Remodel the Tumor Microenvironment in Pediatric Gliomas

Khatereh Khorsandi, Paulina Velsquez, Dalia Haydar

Abstract BACKGROUND Pediatric high-grade gliomas (pHGG) are characterized by an immunologically cold and highly immunosuppressive tumor microenvironment (TME). It is dominated by M2-like tumor-associated macrophages (TAMs), which impair CAR T-cell function and persistence. However, broad myeloid targeting can be detrimental, as recent …

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Dual-agent photodynamic therapy using methylene blue and zinc oxide nanoparticles: sequential illumination enhances apoptotic response in melanoma

Homa Sadat Esfahani, Mehrangiz Ghasemi, Khatereh Khorsandi, Reza Hosseinzadeh et autres

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Abstract A039-PR007: Reprogramming the Myeloid Tumor Microenvironment with CD123 CAR T Cells Enhances B7-H3 CAR T Cell Therapy in DIPG

Khatereh Khorsandi, Jaquelyn T. Zoine, Mireya Paulina Velasquez, Dalia Haydar

Abstract Background: Despite promising safety profiles, B7-H3 CAR T cell therapies have yet to demonstrate meaningful clinical efficacy in diffuse intrinsic pontine glioma (DIPG), a devastating pediatric brain cancer characterized by a profoundly immunosuppressive tumor microenvironment (TME). This TME is dominated by …

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DMG-07. Enhancing CAR T-Cell Therapy in DIPG Through Dual Targeting of CD123 and B7-H3

Khatereh Khorsandi, Dalia Haydar

Abstract Background Tumor-associated macrophages (TAMs) are key contributors to the immunosuppressive tumor microenvironment (TME) in aggressive, cold tumors like Diffuse Intrinsic Pontine Glioma (DIPG). TAMs limit the efficacy and persistence of CAR T cells while driving T-cell exhaustion. This study investigates whether …

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Investigation on the phenytoin sodium channel-blocker effect in PDT of MDA MB 231 breast cancer using a positively charged PS

HomaSadat Esfahani, Reza Hosseinzadeh, Khatereh Khorsandi

Cancer therapy, due to the rising number of detected and reported cases, is one of the most important goals of scientists worldwide. Among these, there is a strong interest in using effective noninvasive protocols for cancer therapy. This study aims to investigate …

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CAR-T cell therapy in brain malignancies: obstacles in the face of cellular trafficking and persistence

Serge Yaacoub, Elton L VanNoy, Stefanyda Maslova, Abigail Haffey et autres

Chimeric Antigen Receptor T (CAR-T) cell therapy offers substantial promise for the treatment of brain malignancies, yet its clinical translation remains limited. Tumors such as Glioblastoma Multiforme (GBM), Diffuse Intrinsic Pontine Glioma (DIPG), and Medulloblastoma (MB) are associated with poor prognoses and …

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Translational Approach: Dual-Mode Therapy with Selenium and Irradiation Enhances Doxorubicin Effectiveness in Triple-Negative Breast Cancer

Zahra Kianmehr, Khatereh Khorsandi, Fedora Khatibi Shahidi

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Synergic anti-tumor effects of photodynamic therapy and resveratrol on triple-negative breast cancer cells

Khatereh Khorsandi, SMahmoud A. Najafi

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Techniques for Syngeneic Allograft Injections in Mice for Establishment of Pediatric Brain Tumor Models

Elton L VanNoy, Abigail Haffey, Serge Yaacoub, Lynne El Ghorayeb et autres

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Recent Trends in Improving Resistance against Diseases Using Molecular Genetics and Omics Tools

Tahir Usman, Afsha Bibi, Syed Ali Raza Shah, Tamanna Gul et autres

CHIEF ORGANIZER AND FOCAL PERSON MESSAGE Dear Participants, It is with immense pleasure and excitement that I extend my warmest welcome to you for the upcoming 1st International Conference on Recent Trends in Improving Resistance Against Diseases Using Molecular Genetics and OMICS …

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