Aina Martín-Medina

Impact of lung-resident Mesenchymal Stem Cells on Epithelial Wound Healing in Idiopathic Pulmonary Fibrosis

Aina Martín-Medina, Joan Truyols-Vives, Andreas Jahn, Carlos Río et autres

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Repetitive human UC-MSC administration limits the progression of pulmonary fibrosis induced by repetitive bleomycin instillation

Joan Truyols-Vives, Alexandre Oliver-Roca, Gabriel Escarrer-Garau, Cristina Gómez-Bellvert et autres

The anti-fibrotic effects of mesenchymal stem cells (MSC) have been demonstrated in animal models of pulmonary fibrosis, but it is being difficult to translate these results in patients with idiopathic pulmonary fibrosis (IPF). Preclinical studies mostly analyzed the effects of a single …

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Lung resident mesenchymal stem cells in idiopathic pulmonary fibrosis

Gabriel Escarrer-Garau, Aina Martín-Medina, Joan Truyols-Vives, Cristina Gómez-Bellvert et autres

Current evidence suggests that lung resident mesenchymal stem cells (LRMSC) contribute to idiopathic pulmonary fibrosis (IPF) by differentiating into myofibroblasts. Our transcriptomic analysis supported this since mesenchyme development and collagen metabolism were two different biological processes between IPF and control LRMSC [1]. …

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In Vivo and In Vitro Pro-Fibrotic Response of Lung-Resident Mesenchymal Stem Cells from Patients with Idiopathic Pulmonary Fibrosis

Gabriel Escarrer-Garau, Aina Martín-Medina, Joan Truyols-Vives, Cristina Gómez-Bellvert et autres

Lung-resident mesenchymal stem cells (LR-MSC) are thought to participate in idiopathic pulmonary fibrosis (IPF) by differentiating into myofibroblasts. On the other hand, LR-MSC in IPF patients present senescence-related features. It is unclear how they respond to a profibrotic environment. Here, we investigated …

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Identification of a panel of circulating miRNAs for the detection of COPD

Noemi Cerón Pisa, Amanda Iglesias, Aina Martín-Medina, Meritxell López et autres

COPD is a frequent, chronic disease characterized by chronic airflow limitation due to anomalies of the respiratory and/or alveolar tracts, mostly caused by exposure to tobacco. Moreover, it is the third leading cause of death in the world, in consequence their early …

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Mitochondrial Dysfunction in Lung Resident Mesenchymal Stem Cells from Idiopathic Pulmonary Fibrosis Patients

Josep Mercader, Aina Martín-Medina, Joan Truyols-Vives, Gabriel Escarrer-Garau et autres

Idiopathic pulmonary fibrosis (IPF) is characterized by an aberrant repair response with uncontrolled turnover of extracellular matrix involving mesenchymal cell phenotypes, where lung resident mesenchymal stem cells (LRMSC) have been supposed to have an important role. However, the contribution of LRMSC in …

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The Role of IL-33/ST2 in COPD and Its Future as an Antibody Therapy

L Riera, Laura Cànaves‐Gómez, Amanda Iglesias, Aina Martín-Medina et autres

COPD is a leading cause of mortality and morbidity worldwide and is associated with a high socioeconomic burden. Current treatment includes the use of inhaled corticosteroids and bronchodilators, which can help to improve symptoms and reduce exacerbations; however, there is no solution …

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Mesenchymal Stem Cells from COPD Patients Are Capable of Restoring Elastase-Induced Emphysema in a Murine Experimental Model

Carlos Río, Andreas Jahn, Aina Martín-Medina, Alba Marina Calvo Bota et autres

COPD is a chronic lung disease that affects millions of people, declining their lung function and impairing their life quality. Despite years of research and drug approvals, we are still not capable of halting progression or restoring normal lung function. Mesenchymal stem …

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Effects of Inhaled Corticosteroids on the Innate Immunological Response to Pseudomonas aeruginosa Infection in Patients with COPD

Noemi Cerón-Pisa, Hanaa Shafiek, Aina Martín-Medina, Javier Verdú et autres

(PA) infection in patients with COPD. We aimed to evaluate the effects of ICS on alveolar macrophages in response to PA in COPD patients with and without baseline ICS treatment (COPD and COPD + ICS, respectively) as well as smoker and nonsmoker …

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TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer

Aina Martín-Medina, Noemi Cerón-Pisa, Esther Martinez-Font, Hanaa Shafiek et autres

The most frequent cause of death by cancer worldwide is lung cancer, and the 5-year survival rate is still very poor for patients with advanced stage. Understanding the crosstalk between the signaling pathways that are involved in disease, especially in metastasis, is …

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Hsa-Mir-320c, Hsa-Mir-200c-3p, and Hsa-Mir-449c-5p as Potential Specific miRNA Biomarkers of COPD: A Pilot Study

Noemi Cerón-Pisa, Amanda Iglesias, Hanaa Shafiek, Aina Martín-Medina et autres

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease commonly induced by cigarette smoke. The expression of miRNAs can be altered in patients with COPD and could be used as a biomarker. We aimed to identify a panel of miRNAs in …

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Profibrotic and proinflammatory pulmonary response to bleomycin in a Swiss nude mice model

Kristiyan Stiliyanov Atanasov, Joan Truyols-Vives, Cristina Gómez, Teresa de Francisco et autres

Mesenchymal stem cell therapy is a promising strategy to treat idiopathic pulmonary fibrosis (IPF) and xenotransplantation of human cells into immunodeficient mice might lead to a suitable experimental approach. Bleomycin (BLM)-induced pulmonary fibrosis (PF) is the most used animal model for the …

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