Roger E. Moore

Key regulatory roles of PRDM1 in human NK-cell differentiation and activation

Xuxiang Liu, Yunfei Shi, Jibin Zhang, Kunal Shetty et autres

Abstract PRDM1 , encoding a transcription factor (TF), regulates plasma cell and CD8 + T-cell terminal differentiation and T h 2 lineage specification, while its role in human NK-cell differentiation and homeostasis is largely unknown. Here, we employed a multi-omics approach to …

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Repurposing Nilotinib as a Selective P38β Inhibitor in Hematopoietic Malignancies: Clinical Evidence and Mechanistic Insights

Xu Hannah Zhang, Jack Hsiang, Sangkil Nam, Hongzhi Li et autres

Background: Cutaneous T cell lymphoma (CTCL) is an incurable cancer characterized by elevated p38β and p38γ and downregulated tumor-suppressive p38α. Objectives: We aimed to identify selective p38β inhibitors and investigate their mechanisms and therapeutic implications in hematologic malignancies. Methods: A high-throughput screen …

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8-Cl-Ado and 8-NH2-Ado synergize with venetoclax to target the methionine-MAT2A-SAM axis in acute myeloid leukemia

Jiamin Guo, Ralf Buettner, Li Bo Du, Zhenlong Li et autres

Targeting the metabolic dependencies of acute myeloid leukemia (AML) cells is a promising therapeutical strategy. In particular, the cysteine and methionine metabolism pathway (C/M) is significantly altered in AML cells compared to healthy blood cells. Moreover, methionine has been identified as one …

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Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis

Marcella Birtele, Ashley Del Dosso, Tiantian Xu, Tuan N. Nguyen et autres

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Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

Heon Shin, Amy W-S Leung, Kevin R Costello, Parijat Senapati et autres

The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation. We report here that DNMT1 function is regulated by O -GlcNAcylation, a protein modification that is sensitive to glucose levels, and that elevated O -GlcNAcylation of DNMT1 from …

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Author response: Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

Heon Shin, Amy W-S Leung, Kevin R Costello, Parijat Senapati et autres

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Long non-coding RNA lncMGC mediates the expression of TGF-β-induced genes in renal cells via nucleosome remodelers

Mitsuo V. Kato, Zhuo Chen, Sadhan Das, Xiwei Wu et autres

Background: MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play key roles in diabetic kidney disease (DKD). The miR-379 megacluster of miRNAs and its host transcript lnc-megacluster (lncMGC) are regulated by transforming growth factor-β (TGF-β), increased in the glomeruli of diabetic mice, and …

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ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner

Anthony Chan, Mingli Li, Qiao Liu, Nicole Mattson et autres

Epigenetic dysregulation of cell cycle is a hallmark of tumorigenesis in multiple cancers, including hepatocellular carcinoma (HCC). Nonetheless, the epigenetic mechanisms underlying the aberrant cell cycle signaling and therapeutic response remain unclear. Here, we used an epigenetics-focused CRISPR interference screen and identified …

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The autism-associated gene SYNGAP1 regulates human cortical neurogenesis

Marcella Birtele, Ashley Del Dosso, Tiantian Xu, Tuan N. Nguyen et autres

Abstract Autism spectrum disorder (ASD) is a genetically heterogeneous disorder linked with rare, inherited and de novo mutations occurring in two main functional gene categories: gene expression regulation and synaptic function 1 . Accumulating evidence points to dysregulation in cortical neurogenesis as …

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The autism-associated gene SYNGAP1 regulates human cortical neurogenesis

Giorgia Quadrato, Marcella Birtele, Ashley Del Dosso, Tiantian Xu et autres

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Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

Jerlisa Ann C. Arizala, Pritsana Chomchan, Haitang Li, Roger E. Moore et autres

The HIV-1 infectious cycle requires viral protein interactions with host factors to facilitate viral replication, packaging, and release. The infectious cycle further requires the formation of viral/host protein complexes with HIV-1 RNA to regulate the splicing and enable nucleocytoplasmic transport. The HIV-1 …

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Fibrinogen and the prediction of residual obstruction manifested after pulmonary embolism treatment

Benjamin Planquette, Olivier Sanchez, James J. Marsh, Peter G. Chiles et autres

Residual pulmonary vascular obstruction (RPVO) and chronic thromboembolic pulmonary hypertension (CTEPH) are both long-term complications of acute pulmonary embolism, but it is unknown whether RPVO can be predicted by variants of fibrinogen associated with CTEPH.We used the Akaike information criterion to select …

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