Alessandra Cazzaniga

Autophagy in MASLD : A Metabolic and Precision Medicine Perspective

Alessandra Cazzaniga, Silvia Frigo, Alessandro Cherubini, Eniada Rrapaj et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver condition worldwide and a major contributor to cirrhosis and hepatocellular carcinoma (HCC). While metabolic triggers such as obesity and insulin resistance are key drivers of MASLD, growing evidence has identified …

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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Claudia Moscheni, Alessandra Cazzaniga, Laura Locatelli, Azzurra Sargenti et autres

Chemoresistance is one of the most significant factors impeding the progress of cancer therapy (1). It is known that neoplastic cells accumulate magnesium and frequently upregulate one of its transporters, i.e.TRPM7 (2). We have investigated magnesium homeostasis in a model of chemoresistance …

Alternative methods, new approach methodologies (NAMs) and artificial intelligence (AI): Approaching the future of science

Francesca Caloni, Alessandra Cazzaniga, Arno C. Gutleb, Maurizio Gualtieri et autres

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Interplay among lipoprotein(a), hepatic and vascular damage in individuals with metabolic dysfunction

Serena Pelusi, Chiara Macchi, Sara Margarita, Irene De Matteis et autres

BACKGROUND: The relationship between plasma lipoprotein(a) [Lp(a)] levels and metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear. The aim of this study was to examine the combined effects of Lp(a) levels on liver and vascular damage. METHODS: The study was conducted using …

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New approach methodologies (NAMs): The strategic vision in science

F. Caloni, Alessandra Cazzaniga, Arno C. Gutleb, Thomas Härtung et autres

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Non-animal models: Complexity for interactions…Connecting science

F. Caloni, Alessandra Cazzaniga, Arno C. Gutleb, Thomas Härtung et autres

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Ultrastructural features mirror metabolic derangement in human endothelial cells exposed to high glucose

Roberta Scrimieri, Laura Locatelli, Alessandra Cazzaniga, Roberta Cazzola et autres

High glucose-induced endothelial dysfunction is the early event that initiates diabetes-induced vascular disease. Here we employed Cryo Soft X-ray Tomography to obtain three-dimensional maps of high D-glucose-treated endothelial cells and their controls at nanometric spatial resolution. We then correlated ultrastructural differences with …

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The Interplay between TRPM7 and MagT1 in Maintaining Endothelial Magnesium Homeostasis

Sara Castiglioni, Laura Locatelli, Giorgia Fedele, Alessandra Cazzaniga et autres

The transient receptor potential cation channel subfamily M member 7 (TRPM7) is an ubiquitous channel fused to an α-kinase domain involved in magnesium (Mg) transport, and its level of expression has been proposed as a marker of endothelial function. To broaden our …

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Cluster-Assembled Zirconia Substrates Accelerate the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

Sara Castiglioni, Laura Locatelli, Alessandra Cazzaniga, Francesca Maria Orecchio et autres

Due to their high mechanical strength and good biocompatibility, nanostructured zirconia surfaces (ns-ZrOx) are widely used for bio-applications. Through supersonic cluster beam deposition, we produced ZrOx films with controllable roughness at the nanoscale, mimicking the morphological and topographical properties of the extracellular …

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Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration

Jeanette A.M. Maier, Laura Locatelli, Giorgia Fedele, Alessandra Cazzaniga et autres

Magnesium (Mg) is involved in the regulation of metabolism and in the maintenance of the homeostasis of all the tissues, including the brain, where it harmonizes nerve signal transmission and preserves the integrity of the blood-brain barrier. Mg deficiency contributes to systemic …

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The different effect of pharmacological or low-doses of IFN-γ in endothelial cells are mediated by different intracellular signaling pathways

Alessandra Cazzaniga, Vincenzo Miranda, Sara Castiglioni, Jeanette A.M. Maier

Abstract Interferon (IFN)-γ is a proinflammatory cytokine with a crucial role in intercellular communication during innate and acquired immune responses. IFN-γ interacts with many cell types, among which endothelial cells. Here, we show that pharmacological and low-dose kinetically activated (SKA) IFN-γ exert …

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The presence of BBB hastens neuronal differentiation of cerebral organoids – The potential role of endothelial derived BDNF

Giorgia Fedele, Alessandra Cazzaniga, Sara Castiglioni, Laura Locatelli et autres

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