Roxanne Diaz Caceres

Vascular smooth muscle cell state trajectories mediate molecular mechanisms of coronary disease risk

Daniel Y. Li, Soumya Kundu, Paul Cheng, Wenduo Gu et autres

Vascular smooth muscle cells contribute to heritable coronary artery disease risk and undergo complex transitions to multiple disease-related phenotypes. To investigate the genetic basis of these trajectories, we develop a dense timecourse single-cell transcriptomic and epigenetic map of atherosclerosis in a murine …

us (code pays fourni par la source)

Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk

Markus Ramste, Chad S. Weldy, Soumya Kundu, Quanyi Zhao et autres

To systematically identify causal genetic mechanisms that confer risk for coronary artery disease (CAD) in GWAS loci, we mapped genome-wide variant-to-enhancer-to-gene (V2E2G) links in vascular smooth muscle cells (SMC). Enhancers identified by active chromatin features, and further prioritized by base-resolution deep learning …

us, fi (code pays fourni par la source)

Vascular smooth muscle cell atherosclerosis trajectories characterized at single cell resolution identify causal transcriptomic and epigenomic mechanisms of disease risk

D. Li, Soumya Kundu, Paul Cheng, Wenduo Gu et autres

Vascular smooth muscle cells (SMC) contribute to heritable coronary artery disease (CAD) risk and undergo complex cell state transitions to multiple disease related phenotypes. To investigate the genetic basis of SMC state trajectories that underlie the SMC component of CAD causality we …

us (code pays fourni par la source)

Walking Impairment Questionnaire Improves Mortality Risk Prediction Models in a High-Risk Cohort Independent of Peripheral Arterial Disease Status

Kevin T. Nead, Margaret Zhou, Roxanne Diaz Caceres, Jeffrey W. Olin et autres

BACKGROUND: The Walking Impairment Questionnaire (WIQ) is a subjective measure of patient-reported walking performance developed for peripheral arterial disease. The purpose of this study is to examine whether this simple tool can improve the predictive capacity of established risk models and whether …

us (code pays fourni par la source)

Usefulness of the Addition of Beta-2-Microglobulin, Cystatin C and C-Reactive Protein to an Established Risk Factors Model to Improve Mortality Risk Prediction in Patients Undergoing Coronary Angiography

Kevin T. Nead, Margaret Zhou, Roxanne Diaz Caceres, Stephen J. Sharp et autres

us, gb (code pays fourni par la source)

Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease

Nicholas J. Leeper, Jonathan Myers, Margaret Zhou, Kevin T. Nead et autres

us (code pays fourni par la source)