Brendan J. White

Decoding the human PBMC isonome: isoform-level resolution with single-cell long-read transcriptomics

Patricia Hayes Doyle, Madeline L. Page, J. Anthony Brandon, Bernardo Aguzzoli Heberle et autres

Abstract Long-read single-cell RNA sequencing provides an opportunity to understand human health and disease at a level difficult to resolve with bulk or short-read methods. This approach enables isoform-level investigation of cellular diversity and disease mechanisms and definition of cell-types, rather than …

us (code pays fourni par la source)

Decoding the human PBMC isonome

Patricia Hayes Doyle, Madeline L. Page, J. Anthony Brandon, Bernardo Aguzzoli Heberle et autres

Long-read single-cell RNA sequencing provides an opportunity to understand human health and disease at a level difficult to resolve with bulk or short-read methods. This approach enables isoform-level investigation of cellular diversity and disease mechanisms and definition of cell-types, rather than using …

us (code pays fourni par la source)

Mapping medically relevant RNA isoform diversity in the aged human frontal cortex with deep long-read RNA-seq

Bernardo Aguzzoli Heberle, J. Anthony Brandon, Madeline L. Page, Kayla A. Nations et autres

Determining whether the RNA isoforms from medically relevant genes have distinct functions could facilitate direct targeting of RNA isoforms for disease treatment. Here, as a step toward this goal for neurological diseases, we sequenced 12 postmortem, aged human frontal cortices (6 Alzheimer …

us, gb (code pays fourni par la source)

Using deep long-read RNAseq in Alzheimer’s disease brain to assess medical relevance of RNA isoform diversity

Bernardo Aguzzoli Heberle, J. Anthony Brandon, Madeline L. Page, Kayla A. Nations et autres

Abstract Due to alternative splicing, human protein-coding genes average over eight RNA isoforms, resulting in nearly four distinct protein coding sequences per gene. Long-read RNAseq (IsoSeq) enables more accurate quantification of isoforms, shedding light on their specific roles. To assess the medical …

us, gb (code pays fourni par la source)

Congenital Ureteral Ectopia in Continent and Incontinent-Related Entlebucher Mountain Dogs: 13 Cases (2006–2009)

Carolyn North, John M. Kruger, P.J. Venta, J. Michael Miller et autres

BACKGROUND: Ectopic ureters (EUs) associated with varying combinations of urinary incontinence, hydronephrosis, and urinary tract infection have been identified in related North American Entlebucher Mountain Dogs. OBJECTIVES: To characterize the disease phenotype in affected dogs and evaluate possible modes of inheritance. ANIMALS: …

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Characterization of the elF2-Associated Protein p67 During Brain Ischemia and Reperfusion

Cheri R. Owen, C. Lipinski, Andrea B. Page, Brendan J. White et autres

EFFECT OF CALCITONIN-GENE-RELATED PEPTIDE ON OUTCOME OF ISCHEMIC DEFICITS AFTER SUBARACHNOID HEMORRHAGE

Aziz Am, Ic Balley, M Barnes, Adam William Bartlett et autres