L Zhang

A Novel Reporter Mouse for Astrocyte‐Derived Extracellular Vesicles Reveals Enrichment of Cargo at Neuronal Mitochondria

Xiaojia Ren, Zainuddin Quadri, Zhihui Zhu, Xu Fu et autres

ABSTRACT Extracellular vesicles (EVs) mediate intercellular transfer of lipids, proteins, and nucleic acids between cell types. We previously showed that astrocyte‐derived EVs modulate neuronal mitochondria in vitro. Whether endogenous astrocytic EVs associate with neuronal mitochondria in vivo remained unknown. To address this, …

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Ceramide-rich extracellular vesicles as pathogenic biomarkers in traumatic brain injury

Zainuddin Quadri, Zhihui Zhu, Xiaojia Ren, Simone Crivelli et autres

Extracellular vesicles (EVs) contribute to the damage caused by traumatic brain injury (TBI) and can cross the blood-brain barrier (BBB). We analyzed plasma-derived EVs from human TBI patients to identify factors potentially contributing to TBI pathology. EVs were isolated using membrane affinity …

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A novel reporter mouse for astrocyte-derived extracellular vesicles reveals trafficking of cargo to neuronal mitochondria

Xiaojia Ren, Zainuddin Quadri, Zhihui Zhu, Xu Fu et autres

Abstract Extracellular vesicles (EVs) mediate intercellular transfer of lipids, proteins, and nucleic acids between nearly all cell types. We previously showed that astrocyte-derived EVs modulate neuronal mitochondria in vitro , but whether endogenous astrocytic EVs are trafficked to neuronal mitochondria in vivo …

us (code pays fourni par la source)

Ceramide-rich extracellular vesicles as pathogenic biomarkers in traumatic brain injury

Zainuddin Quadri, Zhihui Zhu, Xiaojia Ren, Simone M. Crivelli et autres

Extracellular vesicles (EVs) contribute to the damage caused by traumatic brain injury (TBI) and can cross the blood-brain barrier (BBB). We analyzed plasma-derived EVs from human TBI patients to identify factors potentially contributing to TBI pathology. EVs were isolated using membrane affinity …

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Environmental enrichment attenuates cognitive deficits, but does not alter neurotrophin gene expression in the hippocampus following lateral fluid percussion brain injury

R.R Hicks, L Zhang, Amanda Atkinson, M Stevenon et autres

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Effects of chronic ethanol administration on expression of BDNF and trkB mRNAs in rat hippocampus after experimental brain injury

L Zhang, H.S. Dhillon, S. Barrón, R.R Hicks et autres

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Expression of trkB mRNA is altered in rat hippocampus after experimental brain trauma

Ramona Hicks, L Zhang, H.S. Dhillon, M.R.N. Prasad et autres

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