Niclas Colditz

Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile

Gunther Nussbaumer, Martin Benesch, Yura Grabovska, Alan Mackay et autres

BACKGROUND: The term gliomatosis cerebri (GC), a radiology-defined highly infiltrating diffuse glioma, has been abandoned since molecular GC-associated features could not be established. METHODS: We conducted a multinational retrospective study of 104 children and adolescents with GC providing comprehensive clinical and (epi-)genetic …

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Treatment-related survival patterns in diffuse intrinsic pontine glioma using a historical cohort: A report from the European Society for Pediatric Oncology DIPG/DMG Registry

Joshua Baugh, Sophie E. M. Veldhuijzen van Zanten, Marta Fiocco, Niclas Colditz et autres

Background: Our aim is to investigate the association of treatment with survival in patients with diffuse intrinsic pontine glioma (DIPG) by examining 6 historical treatment paths. Methods: We retrospectively analyzed data from 409 patients with radiologically centrally reviewed DIPG, sourced from the …

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HGG-49. Gliomatosis cerebri in children: A collaborative report from the European Society for Pediatric Oncology (SIOPE)

Gunther Nussbaumer, Martin Benesch, Gerrit H. Gielen, David Castel et autres

Abstract BACKGROUND: Gliomatosis cerebri (GC), a radiologically defined diffusely infiltrating glioma, is no longer considered a distinct entity since the 2016 WHO classification for tumors of the CNS. Due to its rarity and dismal prognosis treatment recommendations in children remain ambiguous. Using …

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DIPG-77. TREATMENT EXTENT AND THE EFFECT ON SURVIVAL IN DIFFUSE INTRINSIC PONTINE GLIOMA

Joshua Baugh, Niclas Colditz, Geert O. Janssens, Stefan Dietzsch et autres

Abstract BACKGROUND Front line radiotherapy for diffuse intrinsic pontine glioma (DIPG) remains the only standard of care. Is this still appropriate? PATIENTS AND METHODS We examined survival outcomes across six treatment modalities including I) no treatment (n=19), II) radiotherapy alone (n=38), III) …

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Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries

Lindsey M. Hoffman, Sophie E. M. Veldhuijzen van Zanten, Niclas Colditz, Joshua Baugh et autres

Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and histomolecular characteristics between short-term survivors (STSs) and long-term …

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Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location

Michael Karremann, Gerrit H. Gielen, Marion Hoffmann, Maria Wiese et autres

Background: The novel entity of "diffuse midline glioma, H3 K27M-mutant" has been defined in the 2016 revision of the World Health Organization (WHO) classification of tumors of the central nervous system (CNS). Tumors of this entity arise in CNS midline structures of …

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Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease

Sophie E. M. Veldhuijzen van Zanten, Joshua Baugh, Brooklyn Chaney, Dennis de Jongh et autres

Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival. It is therefore time for international collaboration in DIPG research, …

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HG-75CLINICAL, RADIOLOGICAL, AND HISTO-GENETIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A COLLABORATIVE REPORT FROM THE INTERNATIONAL AND SIOP-E DIPG REGISTRIES

Lindsey M. Hoffman, Sophie E. M. Veldhuijzen van Zanten, Niclas Colditz, Joshua Baugh et autres

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a childhood tumor with median survival of < 1 year. The International and SIOP-E DIPG Registries were established to better understand this rare disease. METHODS: Clinical, radiological, and histo-molecular, proteomics data were abstracted from registry …

us, nl, de, ca, au, at, ch, gb, it, hr (code pays fourni par la source)

CLINICAL, RADIOLOGICAL, AND HISTO-GENETIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A COLLABORATIVE REPORT FROM THE INTERNATIONAL AND SIOP-E DIPG REGISTRIES

Lindsey M. Hoffman, Sophie Veldhuijzen van Zanten, Niclas Colditz, Joshua Baugh et autres