Michael Müller

Fatal Outcome After Propafenone Intoxication in an Infant with SVT

Manuel Lange, P. Mier, T. Menke, Michael Müller et autres

All articles of this category (opens in new window) Background: Class IC antiarrhythmic drugs, like propafenone, have been recommended for the treatment of infants with paroxysmal supraventricular tachycardia (SVT). Though class IC antiarrhythmics are highly effective for the treatment of SVT, the …

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Mapping of neuronal redox conditions in a mouse model of Rett syndrome

Hendrik Woeste, Laura van Agen, Michael Müller

Rett syndrome (RTT) is associated with a systemic redox imbalance, potentially provoking cellular dysfunction and contributing to some of the disease symptoms. While previous studies have reported these redox alterations also in brain, the exact cerebral redox pattern remains unclear. We therefore …

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BNB-Modified Perylene, Terrylene, and Quaterrylene Diimides: Introduction of the π-Accepting and Aggregation-Suppressing Diborinic Imide Group in Rylene Dyes

Michael Müller, Jonas Klopf, Alexandra Friedrich, S Lutz et autres

Rylene diimides are among the most intensively researched classes of functional organic dyes. They are characterized by outstanding photoabsorption and -emission properties in combination with excellent photostability and thermal stability. Due to strong intermolecular π–π interactions, the larger, peri -extended rylene diimides, …

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Time as a significant factor in the release of potassium from lithium heparin plasma and serum

Tom Reuter, Michael Müller, Felix Stelter, Jürgen Durner et autres

OBJECTIVES: In most countries the majority of patients are in outpatient care. In difference to hospitalized patients, their blood samples often take hours after collection to centrifugation. The study investigates the release of potassium and the development of pseudohyperkalemia in lithium heparin …

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Quantitative, real-time imaging of spreading depolarization-associated neuronal ROS production

Katharina Dietrich, Michael Müller

Spreading depolarization (SD) causes a massive neuronal/glial depolarization, disturbs ionic homeostasis and deranges neuronal network function. The metabolic burden imposed by SD may also generate marked amounts of reactive oxygen species (ROS). Yet, proper optical tools are required to study this aspect …

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BN-Phenanthrene- and BN-Pyrene-Based Fluorescent Uridine Analogues

Michael Müller, Hermann Neitz, Claudia Höbartner, Holger Helten

Two unprecedented fluorescent nucleosides that feature BN-doped polycyclic aromatic hydrocarbons are presented. One of them, having a BN-modified phenanthrene moiety incorporated, shows blue fluorescence but suffers from poor stability under aqueous conditions. The other nucleoside comprises an internally BN-doped pyrene as the …

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Mitochondrial Proteome Changes in Rett Syndrome

Gocha Golubiani, Laura van Agen, Lia Tsverava, Revaz Solomonia et autres

Rett syndrome (RTT) is a genetic neurodevelopmental disorder with mutations in the X-chromosomal MECP2 (methyl-CpG-binding protein 2) gene. Most patients are young girls. For 7–18 months after birth, they hardly present any symptoms; later they develop mental problems, a lack of communication, …

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Retraction notice to “Intensified mitochondrial hydrogen peroxide release occurs in all brain regions, affects male as well as female Rett mice, and constitutes a life-long burden” [Arch. Biochem. Biophys. 696 (15 December 2020) 10866]

Olusegun L. Adebayo, Ina Dewenter, Lena Rinne, Gocha Golubiani et autres

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Oral Feeding of an Antioxidant Cocktail as a Therapeutic Strategy in a Mouse Model of Rett Syndrome: Merits and Limitations of Long-Term Treatment

Laura Baroncelli, Stefanie Auel, Lena Rinne, Ann-Kathrin Schuster et autres

Rett syndrome (RTT) is a severe neurodevelopmental disorder that typically arises from spontaneous germline mutations in the X-chromosomal methyl-CpG binding protein 2 (MECP2) gene. For the first 6–18 months of life, the development of the mostly female patients appears normal. Subsequently, cognitive …

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The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention

R. David Andrew, Jed A. Hartings, Cenk Ayata, K. C. Brennan et autres

Abstract Background When a patient arrives in the emergency department following a stroke, a traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help protect their jeopardized neurons. One crucial reason is that we have not identified …

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Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization

R. David Andrew, Eszter Farkas, Jed A. Hartings, K. C. Brennan et autres

BACKGROUND: Within 2 min of severe ischemia, spreading depolarization (SD) propagates like a wave through compromised gray matter of the higher brain. More SDs arise over hours in adjacent tissue, expanding the neuronal damage. This period represents a therapeutic window to inhibit …

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Metabolomic Fingerprint of Mecp2-Deficient Mouse Cortex: Evidence for a Pronounced Multi-Facetted Metabolic Component in Rett Syndrome

Gocha Golubiani, Vincenzo Lagani, Revaz Solomonia, Michael Müller

Using unsupervised metabolomics, we defined the complex metabolic conditions in the cortex of a mouse model of Rett syndrome (RTT). RTT, which represents a cause of mental and cognitive disabilities in females, results in profound cognitive impairment with autistic features, motor disabilities, …

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