Bernhard Unsoeld

Cost-effectiveness of combined veno-arterial extracorporeal membrane oxygenation and Impella support (ECPELLA) in infarct-related cardiogenic shock

Priyanka Boettger, Andrija Matetić, Jamschid Sedighi, Bernhard Unsoeld et autres

Aims: Cardiogenic shock carries high early mortality. Combined veno-arterial extracorporeal membrane oxygenation and Impella support (ECPELLA) may improve outcomes but is costly and unevenly available across Europe. Its incremental clinical and economic value compared with guideline-directed medical therapy (GDMT) remains uncertain. Methods: …

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Timing of acute kidney injury in infarction-related cardiogenic shock: early onset signals a high-risk phenotype – a retrospective observational study

Priyanka Boettger, Henriette Preusse-Sondermann, Jamschid Sedighi, Jannik Jobst et autres

BACKGROUND: Acute kidney injury (AKI) is common in cardiogenic shock (CS) and increases mortality, but the prognostic impact of onset timing in infarct-related CS is unclear. We examined whether early versus late AKI onset is associated with differences in patient characteristics and …

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Cardiogenic shock complicated by acute kidney injury: Sex-specific differences and prognostic impact

Priyanka Boettger, Henriette Preusse-Sondermann, Jamschid Sedighi, Jannik Jobst et autres

BACKGROUND: Acute kidney injury (AKI) is a frequent and prognostically relevant complication in infarct-related cardiogenic shock (CS). Although sex differences in cardiovascular outcomes are increasingly recognized, their role in AKI incidence and prognosis in CS remains unclear. OBJECTIVES: To assess sex-specific differences …

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Multimorbidity and frailty as tools for survival prediction in patients undergoing mitral valve edge-to-edge repair - a perspective from the German health care system

K Piayda, Jannik Jobst, Bernhard Unsoeld, M Beil et autres

Abstract Background Mitral valve insufficiency is a common finding in the community setting and incidence increases with age. Mitral valve edge-to-edge repair (M-TEER) offers a valuable option in patients deemed unfit for surgery. Especially in those, frailty and multimorbidity play an evident …

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Prediabetes in acute stroke: prevalence and impact on early clinical outcomes

Priyanka Boettger, Jamschid Sedighi, Henning Lemm, Kerstin Piayda et autres

Abstract Aims We aimed to characterize the burden of dysglycemia in acute stroke and evaluate whether HbA₁c, even below the diabetic threshold, is associated with neurological severity and embolic risk. Methods We conducted a prospective study of patients with ischemic stroke or …

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Clinical implications of the recalibrated CHA₂DS₂-VA score for women after ischemic stroke: a prospective cohort study

Priyanka Boettger, Jamschid Sedighi, Kerstin Piayda, Martin Juenemann et autres

INTRODUCTION: The 2024 ESC atrial fibrillation guidelines introduced the CHA₂DS₂-VA score by removing female sex as an independent risk criterion. Although intended to simplify risk stratification and avoid sex-based overtreatment, the real-world implications for women who present with AF-related ischemic stroke/TIA remain …

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Timing of Acute Kidney Injury in Infarction-Related Cardiogenic Shock: Early Onset Signals a High-Risk Phenotype

Priyanka Boettger, Henriette Preusse-Sondermann, Jamschid Sedighi, Hassan Hassan et autres

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Short-duration atrial fibrillation in ischemic stroke: high risk despite subclinical burden-a prospective cohort study

Priyanka Boettger, Karolis Macius, Jamschid Sedighi, Henning Lemm et autres

BACKGROUND AND PURPOSE: Atrial fibrillation (AF) episodes ≥ 30 s are currently considered clinically relevant in stroke diagnostics. However, shorter AF episodes may signal a significant embolic risk, especially in patients with embolic stroke of undetermined source (ESUS). This study investigates the …

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Prospective Evaluation of the CHA₂DS₂-VA Score: Do Sex Differences Still Matter in Stroke?

Priyanka Boettger, Jamschid Sedighi, Kerstin Piayda, Martin Juenemann et autres

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Short-Duration Atrial Fibrillation in Ischemic Stroke: High Risk Despite Subclinical Burden-A prospective cohort study

Priyanka Boettger, Karolis Macius, Jamschid Sedighi, Henning Lemm et autres

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Sex differences in stroke risk assessment and severity after removal of female sex from clinical scoring: a prospective cohort study

Priyanka Boettger, Jamschid Sedighi, Kerstin Piayda, Martin Juenemann et autres

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Effects of atrial arrhythmia catheter ablation on left ventricular function and severity of mitral regurgitation

Nikolaos Tsianakas, Philipp Bengel, Philipp Huisl, Nikita Schneider et autres

Abstract Background/Introduction Atrial arrhythmias and mitral regurgitation (MR) often co-exist. Usually, patients with high-degree MR are considered not eligible for catheter ablation (CA) of atrial fibrillation (AF) due to perceived less favoured outcomes. However, at least in some patients with secondary MR, …

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