Adam Patterson

Ketogenic Diet and Exercise Improve Peripheral Neuropathy in a Mouse Model of Metabolic Syndrome

Stéphanie Eid, Pongrat Jaisil, Kai Guo, John Mosely Hayes et autres

Metabolic syndrome (MetS) is a growing health concern that increases risk for peripheral neuropathy (PN), defined by nerve degeneration and sensory dysfunction. Although lifestyle strategies, like ketogenic diet (KD) and exercise, are known to mitigate MetS, their efficacy in maintaining nerve health …

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Impact of the Adverse Social Exposome on Survival in Individuals With Amyotrophic Lateral Sclerosis

Dae‐Gyu Jang, Amy Kind, Adam Patterson, Meredith Pedde et autres

BACKGROUND AND OBJECTIVES: An adverse social exposome negatively affects many diseases, but its association with amyotrophic lateral sclerosis (ALS) survival is unknown. This study examined the association between the social exposome measure Area Deprivation Index (ADI) and ALS survival. METHODS: This is …

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PROGRAMMING A FANUC INDUSTRIAL ROBOT FOR INCREMENTAL SHEET FORMING

Asghar Rezasoltani, R. Boehm, Adam Patterson

Robotic Incremental Sheet forming (ISF) is an ideal method for prototyping parts in various applications such as aerospace, automotive, and medical.While the process needs strong and rigid industrial robots, some industrial robot manufacturers haven't developed any add-on designed explicitly for ISF in …

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The determinants of complication trajectories in American Indians with type 2 diabetes

Evan Lee Reynolds, Gülçin Akıncı, Mousumi Banerjee, Helen C. Looker et autres

Metabolomics identifies shared lipid pathways in independent amyotrophic lateral sclerosis cohorts

Stephen A. Goutman, Kai Guo, Masha G. Savelieff, Adam Patterson et autres

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease lacking effective treatments. This is due, in part, to a complex and incompletely understood pathophysiology. To shed light, we conducted untargeted metabolomics on plasma from two independent cross-sectional ALS cohorts versus control participants …

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The determinants of complication trajectories in American Indians with type 2 diabetes

Evan Lee Reynolds, Gülçin Akıncı, Mousumi Banerjee, Helen C. Looker et autres

BACKGROUNDWe aimed to determine whether metabolic syndrome (MetS) affects longitudinal trajectories of diabetic complications, including neuropathy, cardiovascular autonomic neuropathy (CAN), and kidney disease in American Indians with type 2 diabetes.METHODSWe performed a prospective study where participants underwent annual metabolic phenotyping and outcome …

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Untargeted metabolomics yields insight into ALS disease mechanisms

Stephen A. Goutman, Jonathan Boss, Kai Guo, Fadhl Alakwaa et autres

OBJECTIVE: To identify dysregulated metabolic pathways in amyotrophic lateral sclerosis (ALS) versus control participants through untargeted metabolomics. METHODS: Untargeted metabolomics was performed on plasma from ALS participants (n=125) around 6.8 months after diagnosis and healthy controls (n=71). Individual differential metabolites in ALS …

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1992-P: Metabolic Factors Associated with Cognitive Function and Brain Morphology in Type 2 Diabetes

Rosemary E. Henn, Evan Lee Reynolds, Adam Patterson, Robert G. Nelson et autres

Background: Pima Indians from the Gila River Indian Community in Arizona, USA, have a high prevalence of type 2 diabetes and have been studied for decades to evaluate the risk factors for and trajectory of diabetic complications. Here, we aimed to identify …

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532-P: The Longitudinal Determinants of Diabetic Complications in the Pima Indians of Arizona

Evan Lee Reynolds, Robert G. Nelson, Gülçin Akıncı, ROSIE HENN et autres

The 5 components of the metabolic syndrome (MetS) increase the likelihood of developing diabetes, heart disease, and stroke, but their association with neuropathy and diabetic kidney disease (DKD) is less understood. We examined the longitudinal association between the components of the updated …

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High plasma concentrations of organic pollutants negatively impact survival in amyotrophic lateral sclerosis

Stephen A. Goutman, Jonathan Boss, Adam Patterson, Bhramar Mukherjee et autres

OBJECTIVE: To determine whether persistent organic pollutants (POP) affect amyotrophic lateral sclerosis (ALS) survival. METHODS: ALS participants seen at the University of Michigan (Ann Arbor, MI, USA) provided plasma samples for measurement of POPs. ALS disease and clinical features were collected prospectively …

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Protocolo diagnóstico, tratamiento y seguimiento de la diabetes en el embarazo

Diana Tundidor, Adam Patterson, Rosa Corcoy

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Smoking affects the oral glucose tolerance test profile and the relationship between glucose and HbA1c in gestational diabetes mellitus

Anna Aulinas, Adam Patterson, Justa Úbeda, Miguel Angel María María et autres

AIMS: Current smokers in the general population have a lower 2 h plasma glucose after an oral glucose tolerance test (OGTT) and a higher HbA1c than non-smokers, but the relationships between OGTT/HbA1c and smoking status have not been addressed in pregnancy. We …

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