Tugay Avcı

The Advanced Lung Cancer Inflammation Index: A Powerful and Independent Prognostic Factor in Metastatic Gastric Cancer

Tugay Avcı, Mustafa Şahbazlar, Ferhat Ekinci, Atike Pınar Erdoğan

Background and Objectives: The Advanced Lung Cancer Inflammation Index (ALI), a composite marker integrating body mass index (BMI), serum albumin, and neutrophil-to-lymphocyte ratio (NLR), has demonstrated prognostic value in various cancers. However, its role in metastatic gastric cancer (mGC) remains unexplored. This …

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The Effect of HER2 Status on Gastric Cancer Survival and the Clinical Implications of the HER2-Low Definition: A Retrospective Study

Mehmet Uzun, Savaş Gökçek, Ferhat Ekinci, Tugay Avcı et autres

Background and Objectives: HER-2 expression plays a critical role in the biological behavior and treatment of gastric cancer. With the emergence of HER-2-targeted therapies, classification into negative, low, and positive groups has gained clinical importance. The present study focused on assessing the …

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Comparison of the efficacy of mFOLFOX-6 and mDCF regimens in the treatment of metastatic gastric cancer: a multicenter retrospective study

Oğur Karhan, Serdar İleri, Zuhat Urakçı, Yasin Sezgin et autres

Background: Metastatic gastric cancer (GC) and gastroesophageal junction (GEJ) cancer are associated with a poor prognosis. Recent advancements in treatment have incorporated trastuzumab, anti-PD-1 agents, and anti-claudin therapies alongside chemotherapy (ChT), significantly improving outcomes. Contemporary studies predominantly employ doublet ChT as the …

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Real-Life Efficacy of Palbociclib and Ribociclib in Advanced Breast Cancer

Tugay Avcı, Mustafa Şahbazlar, Ferhat Ekinci, Atike Pınar Erdoğan

Background: Clinical trials in metastatic hormone receptor-positive (HR+) human epidermal growth factor receptor-2 (HER2)-negative patients have shown that cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors both increase response rates and provide survival benefits. The efficacy of these therapies needs to be supported by …

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Positive Lymph Node Ratio as a new prognostic score in Geriatric patients with operated gastric cancer

Ömer Acar, Onur Yazdan Balçık, Muslih Ürün, Tugay Avcı et autres

Objective: The pivotal prognostic determinant for recurrence and survival in surgically treated gastric cancer (GC) patients remains the lymph node status. Despite the adoption of D2 lymph node dissection as the standard approach in recent years, its association with increased morbidity in …

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Comparison of the efficacy of sunitinib and pazopanib in patients with advanced non-clear renal cell carcinoma

Hasan Çağrı Yıldırım, Ertuğrul Bayram, Elvin Chalabiyev, Nargız Majidova et autres

Non-clear cell renal cell carcinoma (non-ccRCC) is a highly heterogeneous disease group, accounting for approximately 25% of all RCC cases. Due to its rarity and especially heterogeneity, phase III trial data is limited and treatment options generally follow those of clear cell …

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Factors Affecting Recurrence and Survival in Stage IIA Colon Cancer Patients

Mert Erciyestepe, Oğuzhan Selvi, Gülhan Dinç, Ahmet Emin Öztürk et autres

INTRODUCTION: Our study delves into the intricate interplay of risk factors and the strategic selection of adjuvant therapy, scrutinizing their influence on recurrence and survival outcomes in stage IIA (T3N0M0) colon cancer patients. MATERIALS AND METHODS: The study examined the medical records …

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Efficacy of first-line CDK 4-6 inhibitors in premenopausal patients with metastatic breast cancer and the effect of dose reduction due to treatment-related neutropenia on efficacy: a Turkish Oncology Group (TOG) study

Hasan Çağrı Yıldırım, Caner Kapar, Barış Köksal, Mustafa Seyyar et autres

The only phase 3 study on the effectiveness of CDK 4-6 inhibitors in first-line treatment in premenopausal patients with hormone receptor (HR) positive, HER2 negative metastatic breast cancer is the MONALEESA-7 study, and data on the effectiveness of palbociclib is limited. Data …

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Prognostic significance of PNI, SIRI and LIPI in non small-cell lung cancer

Onur Yazdan Balçık, Ali AYTAÇ, Tugay Avcı, Bilgin Demir et autres

Aim: Non-small cell lung cancer (NSCLC) is one of the 3 most common and deadly cancers. The aim of the current study is to investigate whether Prognostic Nutritional Index /PNI), Systemic Immune-Inflammation Index (SIRI), Lung Immune Prognostic Index (LIPI) has a prognostic …

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Hypercalcemia and Acute Kidney Injury Due to Oral Vitamin D Replacement

İlter Bozacı, Tugay Avcı, Sevil Nalbant, İbrahim Vasi et autres

Vitamin D (calciferol), is a fat-soluble vitamin and it is contained in very few foods. The main source of this vitamin is skin production. Subclinical vitamin D deficiency, diagnosed by a low 25 hydroxy vitamin D level, is a very common disorder. …

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Oral D Vitamin Replasmanına Bağlı Gelişen Hiperkalsemi ve Akut Böbrek Hasarı

İlter Bozacı, Tugay Avcı, Sevil Nalbant, İbrahim Vasi et autres

Eculizumab Experince at a Patient With Atypical Hemolitic Uremic Syndrome

İlter Bozacı, Gökhan Temïz, İbrahim Vasi, Tugay Avcı

er ri in nc ce e a at t a a P Pa at ti ie en nt t W Wi it th h A At ty yp pi ic ca al l H He em mo ol li it ti ic …

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