Thomas Linder

Racial bias in artificial intelligence for mammography: a challenge todiagnostic justice and equity in Brazil

Luis Gustavo Machado Farias, Alan Cristian Cordeiro Siqueira, Kammilly Fernanda Alves Dos Santos, Cássio ZINI et autres

Introduction: The application of artificial intelligence to mammography has shown promise to improve breast cancer screening, reducing interpretative variability and optimizing early detection. However, variations in performance between different population groups and clinical settings raise concerns about the validity and equity of …

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Viés racial na inteligência artificial para mamografia: um desafio à justiça e à equidade diagnóstica no Brasil

Luis Gustavo Machado Farias, Alan Cristian Cordeiro Siqueira, Kammilly Fernanda Alves Dos Santos, Cássio ZINI et autres

Introduction: The application of artificial intelligence to mammography has shown promise to improve breast cancer screening, reducing interpretative variability and optimizing early detection. However, variations in performance between different population groups and clinical settings raise concerns about the validity and equity of …

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Population-based differences in otosclerosis: a dual-center study of radiological and audiological comparison in Chinese and Swiss patients

Yang Zhao, Yu Chen, Nadja Angela Stenz, Songbo Xue et autres

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Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou et autres

ABSTRACT Functional elastic cartilage remains an unmet challenge in regenerative medicine, limiting reconstructive options for children born with microtia, the congenital malformation of the auricle. The current gold standard treatment relies on harvesting rib cartilage, an invasive procedure associated with donor site …

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Total Ossicular Chain Reconstruction: Is Autologous Material Better Than a TORP?

Nicholas S. Andresen, Filip Kostadinov, Christoph Schlegel, Thomas Linder

INTRODUCTION: Total ossicular chain reconstruction may be performed using autologous cartilage or bone, or with a total ossicular replacement prosthesis (TORP). It is unclear if one method offers better hearing outcomes. The goal of this study was to compare hearing outcomes following …

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Tissue Engineered Elastic Cartilage-Mimetic Auricular Grafts for Ear Reconstruction

Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou et autres

Abstract Patients born with microtia, the congenital malformation of the external ear, face substantial psychosocial strain. Current reconstruction relies on harvesting rib cartilage, an invasive procedure associated with donor site morbidity and unnaturally stiff ears due to the use of hyaline cartilage. …

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Adipose-mesenchymal stem cells enhance the formation of auricular cartilage in vitro and in vivo

Dominika Zielińska, Katarzyna Michalak‐Micka, Hyrije Ademi, Philipp Fisch et autres

Patients suffering from microtia have limited treatment options for auricular reconstruction due to donor-site morbidity, complications, and unaesthetic outcome. Therefore, tissue engineering emerged as an alternative therapeutic option. Here, we generated and characterized human auricular cartilage using differentiated human adipose mesenchymal stem …

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Application of an active middle ear implant in congenital middle ear malformations: A contemporary review

Vagner Antônio Rodrigues da Silva, Henrique Furlan Pauna, Guilherme Corrêa Guimarães, Joel Lavinsky et autres

OBJECTIVE: To evaluate hearing outcomes and postoperative complications among patients with middle and external ear malformations undergoing active middle ear implantation with Vibrant Soundbridge® (VSB). METHODS: Review of the literature. Studies published in English, Portuguese, or Spanish at the following databases: PubMed, …

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A tailored approach in cholesteatoma surgery

Filip Kostadinov, Christoph Schlegel‐Wagner, Thomas Linder

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Rating the aesthetic results after auricular reconstructive surgery for congenital aural atresia with microtia

Njima R. Schläpfer, L. Papp, Dirk Lehnick, Meike Harder et autres

OBJECTIVE: This retrospective study aimed to establish a robust rating system for assessing post-operative outcomes in congenital aural atresia patients undergoing auricular reconstruction. The newly introduced EAR scale, a weighted grading system, not only considers anatomical landmarks but also factors such as …

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Biofabrication of Heterogeneous, Multi‐Layered, and Human‐Scale Tissue Transplants Using Eluting Mold Casting

Enrico Tosoratti, Dominic Rütsche, Maryam Asadikorayem, Simone Ponta et autres

Abstract The creation of multi‐tissue auricular transplants for the treatment of microtia is a challenge due to the complex and layered structure of this anatomical tissue. A novel casting technique for the 3D biofabrication of heterogeneous, multi‐layered, and human‐scale tissue transplants using …

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Combining bioengineered human skin with bioprinted cartilage for ear reconstruction

Dominika Zielińska, Philipp Fisch, Ueli Moehrlen, Sergio Finkielsztein et autres

Microtia is a congenital disorder that manifests as a malformation of the external ear leading to psychosocial problems in affected children. Here, we present a tissue-engineered treatment approach based on a bioprinted autologous auricular cartilage construct (EarCartilage) combined with a bioengineered human …

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