Hiroki Shimura

THE ESTABLISHMENT PROCESS AND EXHIBITION DESIGN OF THE PRIVATE HERITAGE FACILITY “ODAKA TOWN HISTORICAL AND LOCAL ARCHIVES ROOM” IN THE NUCLEAR DISASTER-AFFECTED AREA

Keita UEDA, Nanaha IRISAWA, Tamae KOBAYASHI, Hiroki Shimura et autres

In Odaka, Fukushima Prefecture, which was affected by the nuclear accident, a facility for passing on the local history and experiences of the disaster was built by residents through the renovation of a kindergarten building that had not been demolished. This paper …

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MET signaling drives acquired resistance to erdafitinib in muscle-invasive bladder cancer cells

Syunta Makabe, Kyoka Hoshi, Hiromi Kaneko, Yusuke Masuishi et autres

Muscle-invasive bladder cancer (MIBC) is an aggressive malignancy with high recurrence and poor survival, accounting for the majority of bladder cancer-related deaths. A subset of MIBC harbors FGFR1 amplification or overexpression, associated with increased proliferation and poor prognosis. Although the pan-FGFR inhibitor …

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Guidelines for the diagnosis of Graves' disease, hypothyroidism, painless thyroiditis, chronic thyroiditis (Hashimoto's thyroiditis), and subacute thyroiditis (acute phase)

Tetsuya Tagami, Miyuki Katai, Seigo Kinuya, Noriyuki Koibuchi et autres

In 2002, the Japan Thyroid Association (JTA) established the Thyroid Disease Diagnostic Guidelines Development Working Group, which developed diagnostic guidelines for five major diseases: Graves' disease, hypothyroidism, painless thyroiditis, chronic thyroiditis (Hashimoto's thyroiditis), and subacute thyroiditis (acute phase). Since then, the guidelines …

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Rapid thawing of fresh frozen plasma with a 45°C dry tempering system maintains critical coagulation activities

Shunya Rikimaru, Kosaku Mimura, Nozomi Takano, Mitsuhiko Tadano et autres

BACKGROUND: The ability to rapidly transfuse similar volumes of fresh frozen plasma (FFP) and packed red blood cells can reduce mortality in patients with critical bleeding. This is a compelling reason to thaw FFP quickly in real-world clinical practice. A new dry …

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MET signaling drives acquired resistance to erdafitinib in muscle-invasive bladder cancer cells

Michiru Nishita, Syunta Makabe, Kyoka Hoshi, Hiromi Kaneko et autres

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Model-based estimation of thyroid cancer incidence from ultrasound examinations in the Fukushima Health Management Survey: estimated results considering the non-examinees in the first, second and third rounds of the cohort study

Kunihiko Takahashi, Seiji Yasumura, Hideto Takahashi, Tomoki Nakaya et autres

BACKGROUND: In October 2011, the Fukushima prefectural government started a thyroid ultrasound examination (TUE) as part of the Fukushima Health Management Survey following the Fukushima Daiichi Nuclear Power Plant accident. The proportion of examinees is an important factor when interpreting the results. …

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ER-mitochondria contacts mediate lipid radical transfer via RMDN3/PTPIP51 phosphorylation to reduce mitochondrial oxidative stress

Isshin Shiiba, Naoki Ito, Yuto Ishikawa, Takahiro Nagao et autres

The proximal domains of mitochondria and the endoplasmic reticulum (ER) are linked by tethering factors on each membrane, allowing the efficient transport of substances, including lipids and calcium, between them. However, little is known about the regulation and function of mitochondria-ER contacts …

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Merging of the Fukushima Health Management Survey With the National and Local Cancer Registry to Refine the Detection of Thyroid Cancer Cases After the 2011 Fukushima Daiichi Nuclear Power Plant Accident

Reiko Kimura‐Tsuchiya, Masanori Nagao, Shigehira Saji, Fumikazu Hayashi et autres

BACKGROUND: After the Fukushima Daiichi Nuclear Power Plant accident in 2011, the Fukushima Health Management Survey (FHMS) was implemented in Fukushima Prefecture to promote long-term health care. The FHMS included thyroid ultrasound examination (TUE) for individuals aged ≤ 18 years, including fetuses …

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Response to the letter of Midorikawa et al

Hideto Takahashi, Seiji Yasumura, Kunihiko Takahashi, Tetsuya Ohira et autres

We would like to express our gratitude to Midorikawa et al. for their letter, which provides us with the opportunity to elucidate the Thyroid Ultrasound Examination (TUE)1 in greater detail by responding to their three comments.

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A comprehensive analysis of clinical factors interacting with ectopic intrathyroidal thymus in children and adolescents: The Fukushima Health Management Survey

Satoshi Suzuki, Masanori Nagao, Natsuki Nagamine, Yurie Kobashi et autres

The ectopic intrathyroidal thymus (EIT) is located anywhere in the thyroid gland along the developmental pathway of thymic descent due to thymic migration during embryogenesis. Ultrasonographic findings of papillary thyroid carcinoma (PTC) resemble those of EIT, which is frequently found in children. …

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Etomoxir suppresses the expression of PPARγ2 and inhibits the thermogenic gene induction of brown adipocytes through pathways other than β-oxidation inhibition

Hiroki Shimura, Sota YAMAMOTO, Isshin Shiiba, Mami Oikawa et autres

Brown adipocytes are characterized by a high abundance of mitochondria, allowing them to consume fatty acids for heat production. Increasing the number of brown adipocytes is considered a promising strategy for combating obesity. However, the molecular mechanisms underlying their differentiation remain poorly …

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Clinicopathological Findings of 220 Pediatric, Adolescent, and Young Adult Patients with Thyroid Cancer in Fukushima Medical University Hospital

Yoshiko Matsumoto, Yurie Kobashi, Yukie Yamaya, Mizuki Sekino et autres

Background:Thyroid ultrasound examinations (TUEs), conducted as part of the Fukushima Health Management Survey (FHMS), were initiated to monitor the health status of residents after the Fukushima Daiichi Nuclear Power Plant accident owing to concerns regarding the increased incidence of thyroid cancer among …

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