Mark R. Cullen

Biography as Biology in Drug Development: Bio-Biographical Response States for Translational Pharmacology

J. Baker, Arnab Ghatak, Mark R. Cullen, Ralph I. Horwitz

Abstract Molecular stratification has improved drug development, yet treatment effects remain heterogeneous within apparently similar patients. We propose that selected lived exposures be studied as bio-biographical response states: prospectively measured combinations of experience, candidate mediator biology, and treatment context that may modify …

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The patient the trial cannot see: Clinical reasoning and mechanism in the age of precision medicine

Ralph I. Horwitz, Allison Hayes‐Conroy, Mark R. Cullen, Ida Sim

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Biography is the dark matter of disease pathogenesis

Ralph I. Horwitz, Allison Hayes Conroy, Mark R. Cullen, Ida Sim

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The person–population paradox in clinical medicine

Ralph I. Horwitz, Allison Hayes Conroy, Mark R. Cullen, Ida Sim

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Biography as the dark matter of treatment response

Ralph I. Horwitz, Allison Hayes Conroy, Mark R. Cullen, Ida SimMD

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Reconceptualizing obesity and the modern definition of disease

Ralph I. Horwitz, Allison Hayes Conroy, Mark R. Cullen, Ida Sim

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The imperative of the person in personalized medicine

Ralph I. Horwitz, Allison Hayes‐Conroy, Mark R. Cullen, Adu Matory et autres

In Medicine, it is understood that a person is more than their disease. This has been well recognized, for example in 1927, Francis Peabody remarked, “The secret to the care of the patient is caring for the patient” 1 whilst in 1908, …

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Biosocial Variation in Treatment Response to GLP-1s: Implications for Clinical Care and Health Policy

Ralph I. Horwitz, Sydney Nur Otaka, Allison Hayes‐Conroy, Mark R. Cullen et autres

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Fine Particulate Matter From 2020 California Wildfires and Mental Health–Related Emergency Department Visits

Youn Soo Jung, Mary M. Johnson, Marshall Burke, Sam Heft‐Neal et autres

Importance: A growing body of research suggests that exposure to fine particulate matter (PM2.5; particle size 2.5 microns or smaller) may be associated with mental health outcomes. However, the potential impact of wildfire-specific PM2.5 exposure on mental health remains underexplored. Objective: To …

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The Interaction of Racial-Ethnic and Economic Concentration and its Association with Premature Mortality in U.S. Neighborhoods

Iván Mejía‐Guevara, Mark R. Cullen, Shripad Tuljapurkar, Vyjeyanthi S. Periyakoil et autres

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Integrating biology and biography in medicine: The mind and body are not separate

Ralph I. Horwitz, Mark R. Cullen, Allison Hayes‐Conroy, Ida Sim et autres

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Patient expectations are a feature of treatment strategy rather than a source of bias

Ralph I. Horwitz, J. Baker, Mark R. Cullen

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