Jingyi Fan

Untargeted Cross-Matrix Metabolomics Reveals Tryptophan Metabolism Shift in Children with Autism

Yongxi Cai, Rui Wu, Teng Xu, Hanqi Sun et autres

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Transfer of training through institutional partnership: outcomes from a faculty development program in China

Jonathan Lio, Helen Barrett Fromme, Yue Li, Hongmei Dong et autres

BACKGROUND: International faculty development programs aim to strengthen teaching capacity, yet their impact depends on whether participants can apply new skills in their own institutions. In China, few studies have examined outcomes from multi-institutional programs and the process by which institutional partnerships …

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Multidimensional diversity and regionalpool retention of urban trees across China

Ye Yuan, Jingyi Fan, Jingjing ji, Ying Shi et autres

As urbanization reshapes ecosystems globally, urban forests provide critical ecosystem services. However, traditional taxonomic assessments fail to capture the evolutionary history and functional trait configurations that underpin community assembly mechanisms of urban tree communities. Using the comprehensive Global Urban Tree Species (GUTS) …

Multidimensional diversity and regionalpool retention of urban trees across China

Ye Yuan, Jingyi Fan, Jingjing ji, Ying Shi et autres

As urbanization reshapes ecosystems globally, urban forests provide critical ecosystem services. However, traditional taxonomic assessments fail to capture the evolutionary history and functional trait configurations that underpin community assembly mechanisms of urban tree communities. Using the comprehensive Global Urban Tree Species (GUTS) …

Associations of plasma proteomic and polygenic profiling with incident psoriasis risk: a prospective cohort study

Ting Tian, Tian Tian, Tongtong Hong, Yong He et autres

Background: Psoriasis is a common chronic immune-mediated disease with substantial systemic and public health burden, yet early molecular signatures associated with its onset remain insufficiently characterised. Although both circulating proteins and genetic susceptibility may contribute to psoriasis development, their prospective and joint …

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ANGPTL2 and LTBP2: key mediators of inflammation and mitochondrial dysfunction in atrial fibrillation

Kunlong Tang, Jingyi Fan, Xu Jiwei, Xiaqing Gao et autres

BACKGROUND: Atrial fibrillation (AF) is a common arrhythmia characterized by structural and electrophysiological remodeling. Evidence suggests that inflammation and mitochondrial dysfunction are key pathophysiological drivers, but the core genes underlying these processes remain unclear. METHODS: Using transcriptomic data from public datasets (GSE2240, …

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A non-conjugated peptide-adjuvant system of synthetic peptide-vaccine elicited potent antibody response and opsonic protection against clinical GAS strains

Jingyi Fan, Zeinab G. Khalil, Waleed M. Hussein, István Tóth et autres

Group A Streptococcus (GAS) is a causative agent of life-threatening infections, including pharyngitis, rheumatic fever, and rheumatic heart disease. Currently, no commercial vaccines are licenced to prevent GAS infections. Synthetic peptide-based subunit vaccines composed of minimal antigenic fragments derived from the pathogenic …

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Gut microbiota characteristics and therapeutic effects of fecal microbiota transplantation in children with autism spectrum disorder in central China: a combined cross-sectional and prospective study

Rui Wu, Teng Xu, Yunkai Guo, Yongling Lv et autres

Introduction Gut microbiota dysbiosis is implicated in autism spectrum disorder (ASD), yet scalable therapeutic interventions remain limited. This study investigated gut dysbiosis profiles in children with ASD and evaluated the clinical efficacy of a simplified fecal microbiota transplantation (FMT) protocol using pediatric …

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Association between ultra-processed foods consumption and systemic immune-inflammation biomarkers in US Adults: Cross-Sectional results from NHANES 2003–2023

Ting Tian, Tongtong Hong, Tian Tian, Yong‐Ming He et autres

Background Limited studies have directly linked ultra-processed foods (UPFs) consumption to immunity. This study investigated the association between UPFs intake and systemic immune-inflammation biomarkers in US adults. Methods This cross-sectional study included 34,016 participants from NHANES (2003–2023). Biomarkers related to complete blood …

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RAD23B Promotes Colorectal Cancer Metastasis via the Talin1/Integrin/PI3K/AKT/MMP9 Axis

Jun Li, Zhiyong Zhang, Jingyi Fan, Xiao Liu et autres

Background: Radiation sensitive 23 homolog B (RAD23B), a DNA repair-related protein, plays a contributory role in the development of multiple malignancies. This study aimed to explore the role of RAD23B in promoting colorectal cancer (CRC) metastasis and to elucidate the underlying molecular …

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ITGB1 expression is associated with poor prognosis in colorectal cancer (Preprint)

Jun Li, Chenpeng Wu, Yang Chen, Jingyi Fan et autres

BACKGROUND As one of the most frequently occurring cancers across the planet and the most common gastrointestinal tract cancer, colorectal cancer (CRC) is not only the second most prevalent cancer diagnosed globally, but also ranks third in terms of cancer-related mortality. OBJECTIVE …

A theoretical perspective on professional identity

Hongmei Dong, Renslow D. Sherer, Jonathan Lio, Jingyi Fan et autres

Dear EditorFollowing Sawatsky and Monrouxe’s [1] advice to examine ‘identity’ through a specified theoretical stance, we here venture to explore the notion of ‘professional identity in medicine’ by...

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