2026
article
OpenAlex
Zerui Li, Zhaowen Su, Tanyong Wei, Ming Yang et autres
Achieving targeted-therapy effects through magnetic micro/nanorobots for drug delivery poses challenges in balancing payload capacity for single-trip transport, stability for long-range delivery, and penetration capability for short-range transport. Here, we propose cross-scale robots, termed µ2N-Bots, with magneto-photothermal responsiveness for on-demand degradation to …
cn
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Accès ouvert
2026
article
OpenAlex
Chengbang Lu, Zede Yi, Hongyan Yuan, Haoying Wang et autres
Long-acting oral delivery of macromolecular therapeutics remains difficult, as most oral delivery devices focus on improving gastrointestinal absorption but do not adequately address sustained drug release and frequent dosing. In parallel, many gastric-retentive systems rely on nondegradable structural components, raising concerns regarding …
sg, cn, us, gb
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Zhaowen Su, Zerui Li, Lijun Fang, HoYeon Kim et autres
Autonomous navigation remains a critical challenge for microrobots operating in dynamic and unstructured biological environments, particularly when their motion modality changes during medical procedures. To address this problem, we develop a reliable autonomous navigation strategy that accounts for the metamorphic transition of …
cn, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Xiaoxia Song, Tanyong Wei, Junkai Zhang, Dongrui Li et autres
Magnetic nanorobot swarms hold great promise for biomedicine application, but transporting them over long distances in hash environments often leads to significant swarm losses, posing a significant challenge for their practical applications. Here we show a multi-step “carriers-to-swarms” strategy to protect and …
cn
(code pays fourni par la source)
2025
article
OpenAlex
Kai Wu, Chengbang Lu, Fenghou Yuan, Binghui Song et autres
Abstract The insect cuticle exhibits a diverse array of intricate microstructures, each possessing distinctly different mechanical properties, ranging from rigid components such as head capsules and mandibles to softer structures like larval integuments and intersegmental membranes. While the variations in mechanical properties …
cn, us, hk
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Accès ouvert
2025
article
OpenAlex
Junkai Zhang, Yukun Zhong, Xinran Geng, Zerui Li et autres
Poly (lactic ‐co ‐glycolic acid) (PLGA) is a promising material for creating microrobots for drug delivery due to their biodegradability, biocompatibility, and FDA approval for clinical use. Nevertheless, traditional spherical PLGA drug carriers continue to face challenges, including limited motion efficiency and …
cn
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Accès ouvert
2025
article
OpenAlex
Zhuo Su, Lijun Fang, U Kei Cheang
Automatic navigation of microrobot swarms driven by magnetic fields has attracted considerable attention due to potential applications in biomedical fields. However, achieving minimal loss and maintaining swarm cohesion while traversing heterogeneous landscapes over long distances remains a challenge. This article introduces a …
cn, us
(code pays fourni par la source)
2025
conference-paper
OpenAlex
Yasin Cagatay Duygu, Muhammad I. Azeez, Sangwon Lee, Lasheen Gurusinghe et autres
This paper presents a closed-loop control strategy for the surface motion of magnetically actuated microswimmers, with a focus on high-precision target reaching and smooth trajectory following. A Model Predictive Control (MPC) framework is used to control surface motion, ensuring robust tracking performance. …
us, cn
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Yasin Cagatay Duygu, Sangwon Lee, Austin Liu, U Kei Cheang et autres
Planar magnetic microswimmers offer substantial potential for in vivo biomedical applications, owing to their efficient mass production via photolithography. In this study, we demonstrate the effective control of these microswimmers using an open-loop approach in environments with minimal external disturbances. We investigate …
us, cn
(code pays fourni par la source)
2025
article
OpenAlex
Xiaoxia Song, Hongkai Zhao, Rongxin Qian, Lijun Fang et autres
Glioblastoma multiforme (GBM) is a highly invasive and fatal brain tumor with a grim prognosis, where current treatment modalities, including postoperative radiotherapy and temozolomide chemotherapy, yield a median survival of only 15 months. The challenges of tumor heterogeneity, drug resistance, and the …
cn
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2024
article
OpenAlex
Lijun Fang, Zhuo Su, U Kei Cheang
Under the guidance of an integrated control and imaging system, magnetic microrobots have the capability to navigate within narrow spaces to perform tasks such as cargo delivery and manipulations. However, due to the difficulty of balancing image resolution and width of the …
cn, us
(code pays fourni par la source)
2024
article
OpenAlex
Yukun Zhong, Junkai Zhang, Lijun Fang, U Kei Cheang
Central nervous system (CNS) infections caused by neurosurgery or intrathecal injection of contaminated cerebrospinal fluid are a common and difficult complication. Drug-delivery microrobots are among the latest solutions proposed for antibacterial applications. However, there is a lack of research into developing microrobots …
cn
(code pays fourni par la source)