Luigi Camporota

Extracorporeal Multiorgan Support During Prone Positioning in Severe ARDS: A Physiologic Proof-of-Concept Study

Tobias Lahmer, Eva Ortner, Aritz Pérez Ruiz de Garibay, Luigi Camporota et autres

Background: Prone positioning and lung-protective ventilation are key components of the management of moderate-to-severe acute respiratory distress syndrome (ARDS). However, protective ventilation may be limited by refractory hypercapnia, acidosis, and hemodynamic instability. Whether extracorporeal multiorgan support can complement prone positioning by alleviating …

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Mechanical power and prognosis: a physiological perspective

Francesca Collino, Irene Steinberg, Eleonora Balzani, Ilaria Grava et autres

Extract We read with interest the analysis by Rezoagli et al. [1] of 516 patients from the LUNG SAFE cohort, in which early oxygenation (ratio of arterial oxygen tension (PaO2) to inspiratory oxygen fraction (FIO2)), respiratory mechanics (driving pressure (ΔP), elastance) and …

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PEEP and alveolar recruitment after 60 years of acute respiratory distress syndrome

Domenico Luca Grieco, Rémi Coudroy, Annemijn H. Jonkman, Ling Liu et autres

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Extracorporeal life support in adult critically ill patients: mechanisms of benefit in respiratory and cardiac failure

Vasileios Zochios, J Michael Brewer, Marta Velia Antonini, Daniel Brodie et autres

Extracorporeal life support provides temporary cardiorespiratory support for patients with severe, potentially reversible cardiac and/or respiratory failure refractory to conventional measures. Its application has broadened across a wide spectrum of critical illness, yet the mechanistic basis of its physiologic benefit remains incompletely …

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Computational tools for personalizing treatment of acute respiratory failure, from machine learning to digital twins: a narrative review

Sina Saffaran, Hang Yu, Hossein Shamohammadi, Liam Weaver et autres

Patient-specific computational tools hold great promise for the development of more personalized treatment strategies for acute respiratory failure. Such tools span a continuum from data-driven predictors, to patient-specific mechanistic models, and ultimately to fully realized digital twins with continuous bidirectional model-patient interactions. …

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Imaging in ARDS: physiology-guided decisions in the AI era

Lorenzo Ball, Luigi Camporota, Jean-Michel Constantin

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Extracorporeal Gas Exchange

Yuxiaoyan Zoe Guo, James Talbot-Ponsonby, Chris Meadows, Luigi Camporota

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Managing Respiratory Failure in Late Pregnancy

Kate M Williams, Alastair White, Melanie Nana, Catherine Nelson-Piercy et autres

Background/Objectives: Respiratory failure in late pregnancy represents a complex and high-risk clinical scenario due to physiological adaptations during pregnancy that reduce maternal respiratory reserve, with tightly coupled maternal and foetal outcomes. This review aims to synthesise current evidence on epidemiology, maternal–foetal physiology, …

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Lung recruitability determines the impact of PEEP on mechanical power in ARDS

Domenico L. Grieco, Francesca Collino, Irene Steinberg, Gabriele Pintaudi et autres

Mechanical power increases with positive end-expiratory pressure (PEEP). However, its injurious potential may depend on the available lung gas volume, which can be modified by alveolar recruitment. We investigated how PEEP-induced recruitment affects mechanical power. We analyzed previously collected data on 20 …

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Temporary mechanical support in fulminant myocarditis: prognostic factors and clinical implications from the FULLMOON study

Matthieu Schmidt, Maharajah Ponnaiah, Florent Huang, Santiago Montero et autres

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A consensus of international experts on definition, sampling, treatment, and prevention of peripheral extracorporeal membrane oxygenation cannula-site infection obtained by the Delphi method: the SAVECMO study

Paul Masi, Darryl C. Abrams, Ali Ait Hssain, Martin Balik et autres

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Pulmonary vasoactive drugs

Francesco Vasques, Francesca Pugliese, Christopher Remmington, Luigi Camporota