Cui Hua Liu

The common evolution of fungicide persistence in cryptococcosis patients

Yuyan Xie, Weixin Ke, Xin Fan, Heping Xu et autres

SUMMARY Fungicide persistence, the ability of dormant fungal cells to survive lethal drug exposure, undermines treatment efficacy, yet its clinical evolution remains largely unexplored. We assembled a nationwide collection of clinical Cryptococcus neoformans isolates from China and revealed extensive inter-strain variation in …

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Host-pathogen interactions in tuberculosis: from immunological mechanisms to translational applications

Qiyao Chai, Zehui Lei, Cui Hua Liu

(Mtb), remains the leading cause of death from infectious diseases globally. The complexity of host-Mtb interactions poses a fundamental challenge to developing effective prevention and control measures. Recent advances in multi-omics, spatiotemporal biology, and single-cell technologies have yielded transformative insights into Mtb …

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Lipid accumulation in tuberculosis granulomas inhibits macrophage–CD4+ T cell interactions and infection control

Qiyao Chai, Zhe Lü, M. J. Zhao, Shanshan Yu et autres

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Rab14 restricts pathogens by promoting V-ATPase lysosomal delivery to drive lysosomal acidification

Zehui Lei, Lihua Qiang, P. Ge, Yuyun Qiang et autres

Host restriction factors mediate intrinsic immunity against infections, thus serving as promising targets for host-directed therapy (HDT) against drug-resistant pathogens. While restriction factors counteracting viruses have been extensively studied, those targeting bacteria, particularly those with broad-spectrum activity, remain largely unexplored. Here, through …

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A CLOCK-targeting lncRNA induces trained immunity against tuberculosis

Shanshan Yu, Qiyao Chai, Zhe Lu, Changgen Qiu et autres

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Pathogenic phosphorylation of linear ubiquitin machinery causes inflammasome sensor degradation

Yu Yang, Shanshan Yu, Zhe Lü, Lihua Qiang et autres

Host immune cells are equipped with cytosolic sensors to detect invading pathogens and initiate anti-infectious responses. However, how pathogens undermine host intracellular surveillance for persistent infection is not fully understood. Here, we identify that Mycobacterium tuberculosis protein kinase PknG subverts inflammasome sensor …

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Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity

Yong Zhang, Yesheng Fu, Lihua Qiang, Meng Zhao et autres

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon gene protein (STING) signaling plays a critical role in innate immunity and must be tightly regulated to maintain immune homeostasis, but the mechanism underlying the spatiotemporal regulation of this pathway remains largely elusive. Here, it …

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Pediatric Immunodeficiency Caused by Complement Classical and Alternative Pathway Defects Due to a Homozygous CFI Variant: A Case Report

Cui Hua Liu, Ming Tian, Guanghai Cao, Jitong Li

Complement factor I (CFI) deficiency is a rare primary immunodeficiency that disrupts the classical and alternative complement pathways, potentially causing severe recurrent infections and autoimmune manifestations in pediatric patients. However, the coexistence of both pathways in a pediatric patient is extremely uncommon. …

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A bacterial effector manipulates host lysosomal protease activity–dependent plasticity in cell death modalities to facilitate infection

Zhe Lü, Y. L. Zhang, Yanzhao Zhong, Lihua Qiang et autres

Crosstalk between cell death programs confers appropriate host anti-infection immune responses, but how pathogens co-opt host molecular switches of cell death pathways to reprogram cell death modalities for facilitating infection remains largely unexplored. Here, we identify mammalian cell entry 3C (Mce3C) as …

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Developing next-generation tuberculosis vaccines based on pathogen–host interactions: Towards a holistic perspective

Zehui Lei, Jing Wang, Cui Hua Liu

Author Correction: π-HuB: the proteomic navigator of the human body

Fuchu He, Ruedi Aebersold, Mark S. Baker, Xiu‐Wu Bian et autres

cn, ch, au, us, gb, es, de, ca, jp, sg, nl, ie, my, kr, br, fr, mo, it, in (code pays fourni par la source)

π-HuB: the proteomic navigator of the human body

Fuchu He, Ruedi Aebersold, Mark S. Baker, Xiu‐Wu Bian et autres

cn, ch, au, us, gb, es, de, ca, jp, sg, nl, ie, my, kr, br, fr, mo, it, in (code pays fourni par la source)