Masaharu Noda

Ptprz Signaling, Tubule-Mediated and Macrophage-Mediated Kidney Injury, and Subsequent CKD

Julia Weinmann‐Menke, Hilda Minerva González-Sánchez, Yasunori Iwata, Myriam Meineck et autres

Key Points Ischemia/reperfusion injury induces Ptprz in mouse kidney tubules and macrophages. Stimulated tubules and macrophages expressing Ptprz promote kidney destruction. Ptprz is similarly expressed in inflamed mouse and human (transplant) kidneys, thus are translational. Background Macrophages and tubular epithelial cell interactions …

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Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite

Takashi Matsuda, Kenta Kobayashi, Kazuto Kobayashi, Masaharu Noda

Thirst and salt appetite are temporarily suppressed after water and salt ingestion, respectively, before absorption; however, the underlying neural mechanisms remain unclear. The parabrachial nucleus (PBN) is the relay center of ingestion signals from the digestive organs. We herein identify two distinct …

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Deletion or inhibition of PTPRO prevents ectopic fat accumulation and induces healthy obesity with markedly reduced systemic inflammation

Takafumi Shintani, Ryoko Suzuki, Yasushi Takéuchi, Takuji Shirasawa et autres

AIMS: Chronic inflammation plays crucial roles in obesity-induced metabolic diseases. Protein tyrosine phosphatase receptor type O (PTPRO) is a member of the R3 subfamily of receptor-like protein tyrosine phosphatases. We previously suggested a role for PTPRO in the inactivation of the insulin …

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Deletion or inhibition of PTPRO mitigates diet-induced hepatic steatosis and inflammation in obesity

Takafumi Shintani, Ryoko Suzuki, Yasushi Takéuchi, Takuji Shirasawa et autres

ABSTRACT Chronic inflammation plays crucial roles in obesity-induced metabolic diseases. We herein demonstrated that mice lacking the protein tyrosine phosphatase receptor type O (PTPRO) exhibited the hyper-obese phenotype when fed a high-fat/high-sucrose diet. However, Ptpro -KO mice with hyperobesity showed the markedly …

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Central regulation of body fluid homeostasis

Masaharu Noda, Takashi Matsuda

Extracellular fluids, including blood, lymphatic fluid, and cerebrospinal fluid, are collectively called body fluids. The Na+ concentration ([Na+]) in body fluids is maintained at 135–145 mM and is broadly conserved among terrestrial animals. Homeostatic osmoregulation by Na+ is vital for life because …

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IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice

Hilda Minerva González-Sánchez, Jea-Hyun Baek, Julia Weinmann‐Menke, Amrendra K. Ajay et autres

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Death review of children receiving medical care at home

Jun Natsume, Atsushi Numaguchi, Atsuko Ohno, Mihoko Mizuno et autres

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Distinct CCK-positive SFO neurons are involved in persistent or transient suppression of water intake

昌晴 野田, Masaharu Noda

Distinct CCK-positive SFO neurons are involved in persistent or transient suppression of water intake

Takashi Matsuda, Takeshi Y. Hiyama, Kenta Kobayashi, Kazuto Kobayashi et autres

Abstract The control of water-intake behavior is critical for life because an excessive water intake induces pathological conditions, such as hyponatremia or water intoxication. However, the brain mechanisms controlling water intake currently remain unclear. We previously reported that thirst-driving neurons (water neurons) …

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Insights into olfactory ensheathing cell development from a laser‐microdissection and transcriptome‐profiling approach

Surangi N. Perera, Ruth M. Williams, Rachel Lyne, Oliver Stubbs et autres

Olfactory ensheathing cells (OECs) are neural crest-derived glia that ensheath bundles of olfactory axons from their peripheral origins in the olfactory epithelium to their central targets in the olfactory bulb. We took an unbiased laser microdissection and differential RNA-seq approach, validated by …

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SLC9A4 in the organum vasculosum of the lamina terminalis is a [Na+] sensor for the control of water intake

Hiraki Sakuta, Chia-Hao Lin, Takeshi Y. Hiyama, Takashi Matsuda et autres

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SLC9A4 in the organum vasculosum of the lamina terminalis is a [Na+] sensor for the control of water intake

昌晴 野田, Masaharu Noda