Chiara Iannascoli

Editor’s Note: Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

Monika Aggarwal, Taraswi Banerjee, Joshua A. Sommers, Chiara Iannascoli et autres

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Supplementary Figures from Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

Monika Aggarwal, Taraswi Banerjee, Joshua A. Sommers, Chiara Iannascoli et autres

PDF file, 1010K, Chemical structures of structurally related analogs of the previously identified parent compound NSC 19630 (S1); Effect of NSC 617145 on WRN catalytic functions and DNA unwinding by other helicases (S2); Effect of selected small molecules structurally related to NSC …

Supplementary Figure Legends from Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

Monika Aggarwal, Taraswi Banerjee, Joshua A. Sommers, Chiara Iannascoli et autres

PDF file, 108K.

Supplementary Methods from Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

Monika Aggarwal, Taraswi Banerjee, Joshua A. Sommers, Chiara Iannascoli et autres

PDF file, 106K, Supplemental information regarding proteins, DNA substrates, immunofluorescence, cell cycle analysis by flow cytometry, and additional experimental procedures.

Supplementary Figure Legends from Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

Monika Aggarwal, Taraswi Banerjee, Joshua A. Sommers, Chiara Iannascoli et autres

PDF file, 108K.

Supplementary Figures from Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

Monika Aggarwal, Taraswi Banerjee, Joshua A. Sommers, Chiara Iannascoli et autres

PDF file, 1010K, Chemical structures of structurally related analogs of the previously identified parent compound NSC 19630 (S1); Effect of NSC 617145 on WRN catalytic functions and DNA unwinding by other helicases (S2); Effect of selected small molecules structurally related to NSC …

Supplementary Methods from Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

Monika Aggarwal, Taraswi Banerjee, Joshua A. Sommers, Chiara Iannascoli et autres

PDF file, 106K, Supplemental information regarding proteins, DNA substrates, immunofluorescence, cell cycle analysis by flow cytometry, and additional experimental procedures.

Data from Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

Monika Aggarwal, Taraswi Banerjee, Joshua A. Sommers, Chiara Iannascoli et autres

Abstract Werner syndrome is genetically linked to mutations in WRN that encodes a DNA helicase-nuclease believed to operate at stalled replication forks. Using a newly identified small-molecule inhibitor of WRN helicase (NSC 617145), we investigated the role of WRN in the interstrand …

Data from Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

Monika Aggarwal, Taraswi Banerjee, Joshua A. Sommers, Chiara Iannascoli et autres

Abstract Werner syndrome is genetically linked to mutations in WRN that encodes a DNA helicase-nuclease believed to operate at stalled replication forks. Using a newly identified small-molecule inhibitor of WRN helicase (NSC 617145), we investigated the role of WRN in the interstrand …

The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation

Chiara Iannascoli, Valentina Palermo, Ivana Murfuni, Annapaola Franchitto et autres

The WRN helicase/exonuclease protein is required for proper replication fork recovery and maintenance of genome stability. However, whether the different catalytic activities of WRN cooperate to recover replication forks in vivo is unknown. Here, we show that, in response to replication perturbation …

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Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

Monika Aggarwal, Taraswi Banerjee, Joshua A. Sommers, Chiara Iannascoli et autres

Werner syndrome is genetically linked to mutations in WRN that encodes a DNA helicase-nuclease believed to operate at stalled replication forks. Using a newly identified small-molecule inhibitor of WRN helicase (NSC 617145), we investigated the role of WRN in the interstrand cross-link …

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Novel and recurrent JAG1 mutations in patients with tetralogy of Fallot

Valentina Guida, Francesca Chiappe, Rosangela Ferese, Gianluca Usala et autres

Supporting Information The following Supporting information is available for this article: Fig. S1. Denaturing high-performance liquid chromatography electropherograms. (a) Electropherograms showing c.925G>C, predicting p.Gly309Arg in the JAGGED1 (JAG1) gene from a patient (TF4) with isolated tetralogy of Fallot (TOF) versus wild type. …

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