Dmitrii V. Kalinin

Cryo-EM structures of apo human Factor XIa reveal catalytic-domain flexibility and exposure of the Factor IX-binding site

Alena I. Siutkina, Alexander Neuhaus, Marvin Taterra, Marcel Bermúdez et autres

Abstract Factor XI (FXI) is a key coagulation protease of the intrinsic pathway of blood coagulation and an emerging antithrombotic target. However, the structural transition from zymogen to active Factor XIa (FXIa) has remained poorly understood. Using cryo-EM, we demonstrate that FXI …

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Palladium-Catalyzed Carbonylative Negishi-Type Coupling of Alkyl Zinc Reagents with Benzyl Bromides

Dmitrii V. Kalinin, Jakob B. Jeppesen, Trond Ulven

The first Pd-catalyzed carbonylative Negishi-type reaction allowing coupling of C(sp3)-hybridized benzyl bromides with C(sp3)-hybridized organozinc reagents is described. The protocol relies on the PEPPSI-IPr precatalyst and ex situ-generated CO gas at atmospheric pressure (balloon) to furnish benzyl alkyl ketones. The method requires …

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25a_13C

Dmitrii V. Kalinin, Jakob Bjerregaard Jeppesen, Trond Ulven

23a_13C

Dmitrii V. Kalinin, Jakob Bjerregaard Jeppesen, Trond Ulven

16a_1H

Dmitrii V. Kalinin, Jakob Bjerregaard Jeppesen, Trond Ulven

15a_13C[10]

Dmitrii V. Kalinin, Jakob Bjerregaard Jeppesen, Trond Ulven

7a_13C

Dmitrii V. Kalinin, Jakob Bjerregaard Jeppesen, Trond Ulven

11a_1H

Dmitrii V. Kalinin, Jakob Bjerregaard Jeppesen, Trond Ulven

17a_1H[10]

Dmitrii V. Kalinin, Jakob Bjerregaard Jeppesen, Trond Ulven

12a_13C

Dmitrii V. Kalinin, Jakob Bjerregaard Jeppesen, Trond Ulven

6a_13C

Dmitrii V. Kalinin, Jakob Bjerregaard Jeppesen, Trond Ulven

10a_19F

Dmitrii V. Kalinin, Jakob Bjerregaard Jeppesen, Trond Ulven