Yuka Kajita

Serum IL-6 levels in sepsis predict the development of sepsis-induced disseminated intravascular coagulation

Kosuke Kato, Masayuki Ozaki, Masanobu Tsuda, Takayuki Irahara et autres

Disseminated intravascular coagulation (DIC) significantly increases sepsis mortality rates to 40-80%, making early identification crucial for improved outcomes. Interleukin-6 (IL-6) promotes leukocyte activation and immunothrombosis while serving as an early inflammatory marker, suggesting potential utility for predicting DIC development before overt coagulopathy …

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A Case of Necrotizing Fasciitis in Which Interleukin‐6 Measurement Helped in the Decision for Large‐Scale Amputation of the Left Shoulder and Arm

Zuzanna Granek, Seina Osakabe, Yuka Kajita, Takayuki Irahara et autres

Background: Necrotizing fasciitis (NF) is a life-threatening soft tissue infection with rapid progression of necrosis. Early debridement and further surgical procedures are essential, but decision-making is often difficult. Serum interleukin-6 (IL-6) may serve as a valuable diagnostic parameter for monitoring the patient's …

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Characteristics of inflammation and nutritional metabolism in patients with COVID‐19 pneumonia

Takayuki Irahara, Subaru Tanabe, Salma Umme, Masayuki Ozaki et autres

【目的】COVID‐19肺炎の炎症と栄養代謝動態の特徴を明らかにし, 治療的介入の可能性につき考察する. 【対象と方法】当院救急ICUにCOVID‐19肺炎の診断で入室した患者28名につき, 炎症や栄養代謝に関する血液検査や間接熱量測定にて得られたデータを分析した. 【結果】COVID‐19重症度の内訳は中等症18例, 重症10例であった. 重症は全例に挿管管理を要し4例にvv‐ECMO管理を要した. 炎症データは重症で有意に高くリンパ球数が重症で有意に低下していた（p=0.005）. 栄養代謝ではCONUT値およびPGC‐1α濃度が重症で有意に高値であった（p=0.03, 0.003）. 間接熱量測定を行い得た5例では通常肺炎と比して脂質酸化量が低く呼吸商は高い傾向があった.【結語】COVID‐19肺炎では重症度に応じて高度炎症および免疫麻痺状態に陥っており, 栄養学的リスクも高いことが示唆された. また特有の栄養代謝動態の変化があり栄養療法において考慮すべきと思われた.

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406: ENERGY ADMINISTRATION IN ACUTE NUTRITIONAL THERAPY FOR ICU PATIENTS: USE OF INDIRECT CALORIMETRY

Takayuki Irahara, Eizo Watanabe, Masayuki Ozaki, Masanobu Tsuda et autres

Irahara, Takayuki; Watanabe, Eizo; Ozaki, Masayuki; Tsuda, Masanobu; Kajita, Yuka; Terashima, Tsuguaki; Katsuki, Ryusuke; Tanabe, Subaru; Hirayama, Yuuji; Ooishi, Dai; Kato, Kosuke; Kuge, Yuuji; Kotouge, Kazuki; Ishizu, Keisuke; Kato, Ryoichi Author Information

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Combined, converted, and prophylactic use of resuscitative endovascular balloon occlusion of the aorta for severe torso trauma: a retrospective study

Takayuki Irahara, Dai Oishi, Masanobu Tsuda, Yuka Kajita et autres

Introduction Resuscitative endovascular balloon occlusion of the aorta (REBOA) is used as an intra‐aortic balloon occlusion in Japan; however, protocols for its effective use in different conditions have not been established. This study aimed to summarize the strategies of REBOA use in …

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Combined, Converted, and Prophylactic Use of Resuscitative Endovascular Balloon Occlusion of the Aorta for Severe Torso Trauma: A Retrospective Study

Takayuki Irahara, Dai Oishi, Masanobu Tsuda, Yuka Kajita et autres

Abstract Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is used as an intra-aortic balloon occlusion method in Japan; however, the protocols for its effective use in different pathological conditions remain unclear. This study aimed to summarise the strategies of REBOA …

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A longitudinal change of syndecan-1 predicts risk of acute respiratory distress syndrome and cumulative fluid balance in patients with septic shock: a preliminary study

Yuka Kajita, Tsuguaki Terashima, Hisatake Mori, M M. Islam et autres

Abstract Background The purpose of this study is to investigate the time course of syndecan-1 (Syn-1) plasma levels, the correlation between Syn-1 and organ damage development, and the associations of Syn-1 level with cumulative fluid balance and ventilator-free days (VFD) in patients …

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Increased PD-1 Expression and Altered T Cell Repertoire Diversity Predict Mortality in Patients with Septic Shock: A Preliminary Study

Atsutoshi Tomino, Masanobu Tsuda, Ruri Aoki, Yuka Kajita et autres

Sepsis causes impairment of innate and adaptive immunity by multiple mechanisms, including depletion of immune effector cells and T cell exhaustion. Although lymphocyte dysfunction is associated with increased mortality and potential reactivation of latent viral infection in patients with septic shock, the …

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Flavopiridol inhibits interferon-γ-induced nitric oxide production in mouse vascular endothelial cells

Tsuguaki Terashima, Abedul Haque, Yuka Kajita, Akinori Takeuchi et autres

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Apheresis of activated leukocytes with an immobilized polymyxin B filter

Naoshi Takeyama, Tuneyasu Kumagai, Michiaki Harada, Yuka Kajita et autres

It was assumed that pathologic activation of neutrophils and monocytes is associated with sepsis, acute lung injury/ARDS, and multiple organ failure, and that removal of these cells from the circulation could reduce leukocyte-dependent tissue injury. Cartridges containing polymyxin B (PMX) immobilized to …

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Beneficial effects of the heme oxygenase-1/carbon monoxide system in patients with severe sepsis/septic shock

Shoji Takaki, Naoshi Takeyama, Yuka Kajita, Teru Yabuki et autres

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Beneficial effects of the heme oxygenase-1/carbon monoxide system

Naoshi Takeyama, Shoji Takaki, Yuka Kajita, Teru Yabuki et autres

It has been reported that the blood level of carboxyhemoglobin (CO-Hb) is increased in critically ill patients such as those with sepsis or multiple trauma [ 1 , 2 ]. Because carbon monoxide (CO) is one of the metabolites of heme catabolism, …

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