Yavnika Kashyap

Hemorphins, atypical endogenous opiate peptides, in sickle cell disease and their association with pain

Yanqi Tan, Yavnika Kashyap, Eduardo A. De La Toba, Seth W. Croslow et autres

ABSTRACT: Sickle cell disease (SCD) is a genetic disorder caused by a mutation in the beta hemoglobin gene, resulting in red blood cell (RBC) distortion, hemolysis, and severe pain episodes. Despite advancements in understanding acute crisis pain that is caused by vaso-occlusion, …

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Gut Microbiota and Metabolites on Chronic Pain in Sickle Cell Disease

Yavnika Kashyap, Zaijie Jim Wang

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Role of Gut Microbiota and Microbiota-derived Metabolites in Sickle Cell Pain (Abstract ID: 191525)

Zaijie Jim Wang, Yavnika Kashyap

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BPS2025 - Identification and functional characterization of antinociceptive α9α10 nicotinic acetylcholine receptor antagonists

Kyle M. Kremiller, Gauri Kulkarni, Hirushi T. Gunasekara Kalu Arachchige, Yavnika Kashyap et autres

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BPS2025 - Identification and functional characterization of antinociceptive alpha9alpha10 nicotinic acetylcholine receptor antagonists

Kyle M. Kremiller, Gauri Kulkarni, Hirushi T. Gunasekara Kalu Arachchige, Yavnika Kashyap et autres

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Sex-stratified association of variants in the serotonin 1A receptor gene with acute crisis pain among African American patients with sickle cell disease

Nilanjana Sadhu, Ying He, Yavnika Kashyap, Giokdjen Ilktach et autres

Patients with sickle cell disease (SCD) experience pain in their daily lives. Both the acute and chronic pain phenotypes of this disease exhibit high variability, making pain management a challenge. The underlying reasons for the phenotypic variability are poorly understood. Given the …

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Discovery of Antinociceptive α9α10 Nicotinic Acetylcholine Receptor Antagonists by Stable Receptor Expression

Kyle M. Kremiller, Gauri Kulkarni, Lauren Harris, Hirushi Gunasekara et autres

Chronic neuropathic pain is an increasingly prevalent societal issue that responds poorly to existing therapeutic strategies. The α9α10 nicotinic acetylcholine receptor (nAChR) has emerged as a potential target to treat neuropathic pain. However, challenges in expressing functional α9α10 nAChRs in mammalian cell …

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Gut microbiota dysbiosis alters chronic pain behaviors in a humanized transgenic mouse model of sickle cell disease

Yavnika Kashyap, Zaijie Jim Wang

ABSTRACT: Pain is the most common symptom experienced by patients with sickle cell disease (SCD) throughout their lives and is the main cause of hospitalization. Despite the progress that has been made towards understanding the disease pathophysiology, major gaps remain in the …

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An Alcohol Dehydrogenase 7 Gene Polymorphism Associates with Both Acute and Chronic Pain in Sickle Cell Disease

Yavnika Kashyap, Ying He, Nilanjana Sadhu, Yingwei Yao et autres

Introduction: As the most distressing complication of sickle cell disease (SCD), pain is marked by considerable heterogenicity. In this study we explored the potential association of alcohol dehydrogenase 7 gene (ADH7) polymorphism rs971074 with sickle cell pain. Methods: We analyzed clinical phenotypes …

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Reshaping the gut microbiota affects pain and anxiety-like behaviors in a transgenic model of sickle cell disease

Yavnika Kashyap, Zaijie Jim Wang

Sickle cell disease (SCD) patients experience recurrent episodes of excruciating acute pain and persistent chronic ongoing pain which negatively impacts their quality of life and is the main cause for hospitalizations. Although major progress has been made in understanding the complex SCD …

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Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor

Madeline Hennessy, Anna M. Gutridge, Alexander R. French, Elizabeth S. Rhoda et autres

Akuammine ( 1 ) and pseudoakuammigine ( 2 ) are indole alkaloids found in the seeds of the akuamma tree ( Picralima nitida ). Both alkaloids are weak agonists of the mu opioid receptor (μOR); however, they produce minimal effects in animal …

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Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor

Madeline Hennessy, Anna M. Gutridge, Alexander R. French, Elizabeth S. Rhoda et autres

Akuammine (1) and pseudo-akuammigine (2) are indole alkaloids found in the seeds of the akuamma tree (Picralima nitida). Both alkaloids are weak agonists of the mu opioid receptor (µOR); however, they produce minimal effects in animal models of antinociception. To probe the …

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