Elisa de Almeida Neves Azevedo

HTLV-1 infection in patients with neurological manifestations in Northeast Brazil

Artur Fernando Soares da Silva, Yan Charles da Silva Bastos, Juliana Tiemi Oikawa, Ana Eliza Vargas Eskinazi Sant’Anna et autres

Human T-lymphotropic virus type 1 (HTLV-1) infection is associated with a broad spectrum of neurological manifestations, including conditions that may precede the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This analytical, descriptive cross-sectional study aimed to estimate the prevalence of HTLV-1 infection …

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Genomic epidemiology of dengue virus serotype 3 lineage 3III_B.3.2 in Brazil: insights into its spread and dengue severity amid co-circulation of multiple dengue serotypes

Caroline do Nascimento Ferreira, Carla Adriane Royer, Camila Confortin, Nelson Fernando Quallio Marques et autres

Background: After over a decade of minimal circulation, DENV-3 reemerged in Brazil in 2023, driven by the newly detected lineage 3III_B.3.2. Elucidating the patterns of DENV-3 spread and impact on public health, is critically important in the context of Brazil's hyperendemic dengue …

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Oropouche virus outbreaks in northeast Brazil between 2024–25 are characterized by sustained transmission and spread to newly affected areas

Elverson Soares de Melo, Suzane Melo da Silva, Gustavo Barbosa de Lima, Adalúcia da Silva et autres

Oropouche virus (OROV) has recently expanded in Brazil, establishing transmission in non-endemic regions. This study aims to integrate epidemiological and molecular data to investigate OROV spread in Northeast (NE) Brazil between 2024 and 2025. OROV cases were analyzed regarding ecological risk factors …

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Htlv-1 Infection in Patients With Neurological Manifestations in Northeast Brazil

Artur Fernando Soares da Silva, Yan Charles da Silva Bastos, Juliana Tiemi Oikawa, Ana Eliza Vargas Eskinazi Sant’Anna et autres

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In Vitro Model of the Human Blood–Brain Barrier to Explore HTLV-1 Immunopathogenesis

Ana Beatriz Giles Guimarães, Lucas Coêlho Bernardo‐Menezes, Elisa de Almeida Neves Azevedo, Almerinda Agrelli et autres

Cellular components and inflammatory mediators involved in the transmigration of HTLV-1-infected cells across the blood–brain barrier (BBB) are not fully understood. This study proposes a BBB model to identify the immunological mechanisms associated with HTLV-1 pathogenesis. PBMCs from individuals with HTLV-1-associated Myelopathy/Tropical …

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Oropouche Virus Outbreaks in Northeast Brazil Between 2024-25 are Characterized by Sustained Transmission and Spread to Newly Affected Areas

Elverson Soares de Melo, Suzane Melo da Silva, Gustavo Barbosa de Lima, Adalúcia da Silva et autres

ABSTRACT Oropouche virus (OROV) is a reemerging arbovirus associated with recurrent outbreaks of febrile illness, usually confined to the Amazon biome in South America. However, OROV has recently undergone an extensive expansion in Brazil, establishing local transmission in non-endemic regions, such as …

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Prevalence and first detection of HTLV-2 in a pregnant woman in rural Brazil

Gabriela Rodrigues de Aguiar Leal, Gabriel Galindo Cunha, Ana Eliza Vargas Eskinazi Sant’Anna, Elisa de Almeida Neves Azevedo et autres

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Desempenho do teste rápido de chikungunya em cenário de cocirculação de Zika e dengue no Município do Rio de Janeiro, Brasil

Geani de Oliveira Marins, Thiago Pires, Reinaldo Souza‐Santos, Andréa Sobral de Almeida et autres

The municipality of Rio de Janeiro is one of the most affected by the simultaneous circulation of the chikungunya (CHIKV), the Zika (ZIKV) and the dengue viruses (DENV) in Brazil. Although rapid tests are commercially available in the country, there are still …

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Genomic and phenotypic characterization of the Oropouche virus strain implicated in the 2022–24 large‐scale outbreak in Brazil

Elisa de Almeida Neves Azevedo, Alexandre Ferreira da Silva, Verônica Gomes da Silva, Laís Ceschini Machado et autres

The Orthobunyavirus oropoucheense species encompasses a group of arthropod-borne zoonotic viruses transmitted by biting midges to animals including humans. Several large-scale human outbreaks caused by the prototype member of this species, Oropouche virus (OROV) have been documented since the 1970s and were …

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Genomic and phenotypic characterization of an Oropouche virus strain implicated in the 2023-24 large-scale outbreak in Brazil

Elisa de Almeida Neves Azevedo, Alexandre Freitas da Silva, Verônica Gomes da Silva, Laís Ceschini Machado et autres

Abstract The Orthobunyavirus oropoucheense in a arthropod borne zoonotic pathogen known to infect sylvatic animals and humans by means of biting midges transmission. Several large-scale human outbreaks of Oropouche virus (OROV), primarily confined to the Amazon region, were documented over the decades. …

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Prognostic implications of ΔNp73/TAp73 expression ratio in core-binding factor acute myeloid leukemia

Maria L. Salustiano-Bandeira, Amanda Moreira‐Aguiar, Diego A. Pereira‐Martins, Juan Luiz Coelho‐Silva et autres

The TP73 gene is a member of the TP53 family and, due to differential promoter usage, it may be alternatively transcribed into the transcriptionally active full-length ( TAp73 ) or inactive NH2-terminal truncated ( ΔNp73 ) isoforms. While the encoded full-length TAp73 …

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Study of the permeability of the blood-brain barrier and the intra-thecal inflammatory profile in patients with cerebral manifestations due to SARS-CoV-2

Lucas Coêlho Bernardo‐Menezes, Elisa de Almeida Neves Azevedo, Marton Kaique de Andrade Cavalcante, Flávia Falcão Albuquerque et autres

Background: The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has had effects on the central nervous system in cases of acute neurological manifestations (ANM). Although cytokines, chemokines and immunoglobulins were investigated in patients with acute brain syndromes and SARS-CoV-2 infection, data …