Ashok Srinivasan

Temporal Bone Anatomy at 0.55 T: Comparison to 1.5/3T MR and High-Resolution CT

Lauren J. Kelsey, Nicole Seiberlich, Ashok Srinivasan, Mohannad M. Ibrahim et autres

RATIONALE AND OBJECTIVES: The purpose of this study is to evaluate whether the whole-body 0.55 T MRI may be a clinically acceptable or non-inferior alternative to 1.5T/3T for internal auditory canal (IAC) imaging due to greater field homogeneity and resultant reduced susceptibility …

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Clinical Temporal Bone Imaging at 0.55T: Comparison of Anatomic Evaluation to 1.5/3T MRI and High-Resolution CT

Lauren J. Kelsey, Ashok Srinivasan, Eric A. Liao, Mohannad M. Ibrahim et autres

Motivation: Identify whether 0.55T MRI may be superior or a clinically acceptable alternative to 1.5T/3T for temporal bone evaluation Goal(s): To compare image quality, visibility of temporal bone anatomy, and cochlear measurements at 0.55T vs. 1.5T/3T, using high-resolution CT (HRCT) as the …

Faculty and staff attitudes towards discontinuation of routine gonadal shielding: perceptions before and after policy change in an academic medical center

Obaidah Bitar, Aparna Joshi, Tresa Griffith, Sarah Clos et autres

OBJECTIVES: To evaluate the perception of clinical faculty and staff on the discontinuation of routine gonadal shielding for diagnostic imaging procedures and assess the impact of targeted educational intervention on awareness and comfort levels. METHODS: A pre-post survey study was conducted among …

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Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation

Laura Beatriz Prato, A. Rezzag Lebza, Amandine Consumi, Marine Tessier et autres

Background: Traumatic brain injury (TBI) is a major cause of disabilities in industrialized countries. Cognitive decline typically occurs in the chronic phase of the condition, following cellular and molecular processes. In this study, we described the use of KCC2, a neuronal-specific potassium-chloride …

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Retrospective comparison of routine brain MRI scans in patients at 0.55 T and 1.5/3T

Anna Lavrova, Shruti Mishra, John Kim, Remy R. Lobo et autres

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Memory T-cell enriched haploidentical transplantation with NK cell addback results in promising long-term outcomes: a phase II trial

Swati Naik, Ying Li, Aimee C. Talleur, Subodh Selukar et autres

BACKGROUND: Relapse remains a challenge after transplantation in pediatric patients with hematological malignancies. Myeloablative regimens used for disease control are associated with acute and long-term adverse effects. We used a CD45RA-depleted haploidentical graft for adoptive transfer of memory T cells combined with …

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Reduced toxicity conditioning for hematopoietic stem cell transplantation in children with Diamond-Blackfan anemia

Amr Qudeimat, Shruthi Suryaprakash, Renee M. Madden, Ashok Srinivasan et autres

Not available.

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Disease Status and Interval between Hematopoietic Cell Transplantations Predict Outcome of Pediatric Patients Who Undergo Subsequent Transplantation for Relapsed Hematologic Malignancy

Rebecca Epperly, Ying Li, Subodh Selukar, Emily Y. Zeng et autres

Patients with hematologic malignancies who relapse after allogeneic hematopoietic cell transplantation (HCT) have a poor prognosis. Although proceeding to subsequent HCT can provide potential for long-term survival, there are limited data to guide which patients are most likely to benefit and which …

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Risk-Adapted Donor Lymphocyte Infusion after Hematopoietic Cell Transplant in Pediatric and Young Adult Patients Is Associated with Low Risk of Graft Versus Host Disease

Shruthi Suryaprakash, Yilun Sun, Li Tang, Dinesh Keerthi et autres

Donor lymphocyte infusion (DLI) is a form of adoptive immunotherapy administered in patients experiencing mixed chimerism (MC) or disease relapse after an allogeneic hematopoietic cell transplantation (HCT). Success is limited by the occurrence of acute and chronic graft-versus-host disease (GVHD). To determine …

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Allogeneic Hematopoietic Cell Transplantation for Acute Megakaryocytic Leukemia: A Single Center Study

Shruthi Suryaprakash, Yu Bi, Subodh Selukar, Dinesh Keerthi et autres

Acute megakaryocytic leukemia (AMKL) comprises 4-15% of all acute myeloid leukemia (AML) diagnoses in pediatric patients. Unlike patients with Down syndrome who have a >80% expected survival, the 5-year overall survival (OS) in patients with de novo AMKL ranges between 14-49%. While …

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Allogeneic Hematopoietic Cell Transplantation for Acute Megakaryocytic Leukemia: A Single Center Study

Shruthi Suryaprakash, Yu Bi, Subodh Selukar, Dinesh Keerthi et autres

Introduction Acute megakaryocytic leukemia (AMKL) comprises 4-15% of all acute myeloid leukemia (AML) diagnoses in pediatric patients. Unlike patients with Down syndrome who have a >80% expected survival with dose-reduced chemotherapy, the 5-year overall survival (OS) in patients with de novo AMKL …

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Risk-Adapted Donor Lymphocyte Infusion after Hematopoietic Cell Transplant in Pediatric and Young Adult Patients Is Associated with Low Risk of Graft Versus Host Disease

Shruthi Suryaprakash, Yilun Sun, Li Tang, Dinesh Keerthi et autres

Introduction: Donor lymphocyte infusion (DLI) is a form of adoptive immunotherapy administered to enhance the graft-versus-leukemia (GVL) effect after an allogeneic hematopoietic cell transplantation (HCT). DLI is frequently chosen for its ease of administration and low risk of graft ablation as compared …

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