Kenji Takano

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak, Vasilis Raptis, Yunye He, Tomoko Nakanishi et autres

Males and females exhibit differences in proteome profiles associated with disease risk. However, sex-dimorphic protein quantitative trait loci (SD-pQTL) and their effects on sex differences in health disorders have not been thoroughly investigated. We conducted a sex-stratified, genome-wide association study on 2,922 …

gb, jp, se, us (code pays fourni par la source)

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

Go Sato, Yuya Shirai, Ryunosuke Saiki, Kyuto Sonehara et autres

Current molecular quantitative trait locus catalogs are mostly at bulk resolution and centered on Europeans. Here, we constructed an immune cell atlas with single-cell transcriptomics of >1.5 million peripheral blood mononuclear cells, host genetics, plasma proteomics and gut metagenomics from 235 Japanese …

jp, us (code pays fourni par la source)

Blood DNA virome associates with autoimmune diseases and COVID-19

Noah Sasa, Shohei Kojima, Rie Koide, Takanori Hasegawa et autres

Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, including patients with …

jp, us (code pays fourni par la source)

Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues

Ryuya Edahiro, Kyuto Sonehara, Yuya Shirai, Kian Hong Kock et autres

Several X-linked genes escape from X chromosome inactivation (XCI), while differences in escape across cell types and tissues are still poorly characterized. Here, we developed scLinaX for directly quantifying relative gene expression from the inactivated X chromosome with droplet-based single-cell RNA sequencing …

jp, sg, kr (code pays fourni par la source)

Time to diagnosis of nontuberculous mycobacterial pulmonary disease and longitudinal changes on CT before diagnosis

Makoto Hayashi, Hiroyasu Takishima, Soma Kishino, Keitaro Kishi et autres

Background: The healthcare burden of nontuberculous mycobacterial pulmonary disease (NTM-PD) is increasing, but the diagnosis remains challenging and sometimes requires considerable time. This nested case-control study aims to clarify the time to diagnosis of NTM-PD, the factors that affect diagnosis and diagnostic …

jp (code pays fourni par la source)

Gastrointestinal symptoms in COVID-19 and disease severity: a Japanese registry-based retrospective cohort study

Yuta Matsubara, Hiroki Kiyohara, Yohei Mikami, Kosaku Nanki et autres

jp (code pays fourni par la source)

Time to Diagnosis of Nontuberculous Mycobacterial Pulmonary Disease and Longitudinal Changes on CT Before Diagnosis

Makoto Hayashi, Hiroyasu Takishima, Soma Kishino, Keitaro Kishi et autres

jp (code pays fourni par la source)

A case of angioimmunoblastic T-cell lymphoma presenting with migration of lung shadows

Tomoya Maruyama, Takashi Ishiguro, Kenji Takano, Yoshihiko Shimizu

A 62-year-old woman presented with chronic cough. Chest CT showed multiple nodules and consolidation. Bronchoscopy could not confirm a specific diagnosis. Because her symptoms and lung opacities improved spontaneously, she was followed without treatment. Seven months later, chest radiography showed worsening of …

jp (code pays fourni par la source)

A second update on mapping the human genetic architecture of COVID-19

Shea J. Andrews, Mattia Cordioli, Christine Stevens, Mark J. Daly et autres

Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1 , 2 . Here we present a second updated genome-wide association study (GWAS) …

us, fi, pl, my, ch, gb, Burkina Faso, ca, pr, it, in, Égypte, es, nl, Afrique du Sud, cl, hu, br, fr, be, mx, au, de, jp, py (code pays fourni par la source)

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Ryuya Edahiro, Yuya Shirai, Yusuke Takeshima, Shuhei Sakakibara et autres

Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 coronavirus disease 2019 (COVID-19) patients and 75 …

jp, us (code pays fourni par la source)

Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force

Shotaro Chubachi, Ho Namkoong, Hiromu Tanaka, Kensuke Nakagawara et autres

BACKGROUND: We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant. METHODS: We used secondary data from a database and performed a retrospective …

jp (code pays fourni par la source)

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Qingbo S. Wang, Ryuya Edahiro, Ho Namkoong, Takanori Hasegawa et autres

Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we …

jp, us (code pays fourni par la source)