Karim Gariani

Sarcopenia and Muscle Aging: Updated Insights into Molecular Mechanisms and Translational Therapeutics

T. Nguyen, Tam Dao, Ha Thu Nguyen, Jun-Hyeon Park et autres

Sarcopenia is a progressive, age-related condition characterized by the loss of skeletal muscle mass, strength, and function, which increases the risk of falls, frailty, and loss of independence. Despite growing recognition and its incorporation into geriatric assessments, there is still no approved …

kr, vn, cn, ch (code pays fourni par la source)

Diabetic Peripheral Neuropathy: Current Epidemiology, Diagnostic Advances, Biomarkers, and Management Strategies

Felix T. Kurz, Johann M. Jende, Rarès Salomir, Karl‐Olof Lövblad et autres

Diabetic peripheral neuropathy (DPN) is one of the most common and disabling complications of diabetes mellitus (DM), affecting up to 50% of patients during the course of their disease. The condition manifests predominantly as a distal symmetric polyneuropathy, with early involvement of …

ch, us, de (code pays fourni par la source)

Myosteatosis: Epidemiological Insights, Functional Decline, and Diagnostic Advances

Yan Zhang, Yunju Jo, Shibo Wei, Yeongmin Kim et autres

kr, ch (code pays fourni par la source)

Adapting diabetes education for neurodiverse patients: A COM-B framework analysis of type 1 diabetes and attention deficit hyperactivity disorder

Elise Chivoret, Nader Perroud, Zoltan Pataky, Karim Gariani et autres

ch, us (code pays fourni par la source)

Interleukin-18 binding protein protects against metabolic steatohepatitis

Emmanuel Somm, Yunju Jo, Elodie Perroud, Frédérique Ino et autres

BACKGROUND: Metabolic dysfunction-associated steatohepatitis (MASH) is a frequent consequence of Western diet consumption and liver steatosis. IL-18 binding protein (IL-18BP) limits the action of interleukin-18 (IL-18). Our work aims to study the unknown role of IL-18BP in MASH progression. METHODS: We analyzed …

ch, us, kr, de (code pays fourni par la source)

Impact of Islet Transplantation on Type 1 Diabetes-Related Complication: A Systematic Review

Karim Gariani, Andrea Peloso, Fadi Haidar, Rohan Kumar et autres

Islet transplantation is a valuable therapy for selected type 1 diabetes mellitus (T1DM) patients, especially those with recurrent severe hypoglycemia, glycemic variability, or impaired hypoglycemia awareness. It improves glycemic control and protects against hypoglycemic episodes. Beyond glucose regulation, islet transplantation may mitigate …

ch, us, it, ge, fr (code pays fourni par la source)

Interleukin-18 binding protein deficiency results in gut microbiota dysbiosis and aggravated diet-induced MASH in mice

Emmanuel Somm, Elodie Perroud, Yunju Jo, Karina Lindner et autres

Background & Aims Metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH) are now the most prevalent hepatic disorders worldwide. Growing evidence implicates physiological alterations in the gut–liver axis and gut microbiota dysbiosis in this process. IL-18-binding protein (IL-18BP) forms high affinity …

ch, us, kr (code pays fourni par la source)

Impact of GLP-1 receptor agonist-based therapies on cardiovascular and renal outcomes in diabetic and non-diabetic patients with CKD

Aliona Siniukovich, Christoforos K Travlos, Sarah Freedman, Thomas A. Mavrakanas et autres

BACKGROUND: The effect of glucagon-like peptide-1 (GLP-1) receptor agonists-based therapies on cardiovascular and renal outcomes has not been systematically reviewed across baseline kidney function groups. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) with GLP-1 Receptor Agonists (RAs) …

ch, ca, us (code pays fourni par la source)

The increasing prevalence of Enterobacteriaceae as pathogens of diabetic foot osteomyelitis: A multicentre European cohort over two decades

Laura Soldevila-Boixader, Oscar Murillo, Felix W. A. Waibel, Madlaina Schöni et autres

NAD boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice

Yu-Jen Wang, Daniel S. Gaul, Era Gorica, Jürgen Pahla et autres

NAD+ boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice

Yu-Jen Wang, Daniel S. Gaul, Era Gorica, Jürgen Pahla et autres

Background and aims NAD + (nicotinamide adenine dinucleotide) is a cosubstrate of the sirtuins (SIRT) that are activated upon caloric restriction. Supplementing NAD + precursors such as nicotinamide riboside (NR) has been reported to extend life span and combat metabolic syndrome through …

ch, us (code pays fourni par la source)

Diabetes and At-risk Foot in Low- and Middle-income Countries or Humanitarian Crises, the International Committee of the Red Cross (ICRC) Approach for Better Interprofessional Care

Hubert Vuagnat, Montserrat Castellsague Perolini, Karim Gariani, Zoltan Pataky et autres

us (code pays fourni par la source)