Mark Mason

Narrow-spectrum drug repurposing : targeting Gardnerella vaginalis biofilms associated with bacterial vaginosis

William Johnston, Jamie Smith, Elisa Giammarini, Amy J. Campbell et autres

Aim: Bacterial vaginosis (BV) is the most common vaginal disorder in women of reproductive age. Current therapies are limited by poor activity against biofilms and high recurrence rates (>50%), demonstrating that new antimicrobials are required. Drug repurposing is an attractive approach for …

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Narrow-spectrum drug repurposing: targeting Gardnerella vaginalis biofilms associated with bacterial vaginosis

William Johnston, Jamie Smith, Elisa Giammarini, Amy J. Campbell et autres

AIM: Bacterial vaginosis (BV) is the most common vaginal disorder in women of reproductive age. Current therapies are limited by poor activity against biofilms and high recurrence rates (>50%), demonstrating that new antimicrobials are required. Drug repurposing is an attractive approach for …

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Improving quality and outcomes of extracorporeal cardiopulmonary resuscitation in refractory cardiac arrest: the Phoenix ECPR project

Waqas Akhtar, Eftychia Galiatsou, Sofia Pinto, Maria Comanici et autres

BACKGROUND: Survival for cardiac arrest remains poor, and the use of extracorporeal cardiopulmonary resuscitation (ECPR) has been suggested as a potential therapy to improve outcomes. Harefield Hospital has been performing ECPR for over a decade; however outcomes have been historically poor. METHODS: …

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Central venous pressure as a method of optimising atrio-ventricular delay after cardiac surgery

Alexander Tindale, Ioana Crețu, Naomi Gomez, R Haynes et autres

INTRODUCTION: Haemodynamic atrioventricular delay (AVD) optimisation has primarily focussed on signals that are not easy to acquire from a pacing system itself, such as invasive left ventricular catheterisation or arterial blood pressure (ABP). In this study, standard clinical central venous pressure (CVP) …

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PO-06-040 A RANDOMISED DOUBLE-BLINDED CROSS-OVER STUDY TO EVALUATE THE IMPROVEMENT OF LEFT VENTRICULAR SYSTOLIC FAILURE USING TARGETED LEFT VENTRICULAR ENDOCARDIAL LEAD PLACEMENT IN CARDIAC RESYNCHRONISATION (NCT02174289)

Emily-Jane Cantor, Charles Butcher, R Haynes, Afzal Sohaib et autres

How robust are recommended waiting times to pacing after cardiac surgery that are derived from observational data?

Alexander Tindale, Ioana Crețu, R Haynes, Naomi Gomez et autres

AIMS: For bradycardic patients after cardiac surgery, it is unknown how long to wait before implanting a permanent pacemaker (PPM). Current recommendations vary and are based on observational studies. This study aims to examine why this variation may exist. METHODS AND RESULTS: …

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Classification of arrhythmias using an LSTM- and GAN-based approach to ECG signal augmentation

Ioana Crețu, Alexander Tindale, Maysam Abbod, W. Balachandran et autres

Abstract Funding Acknowledgements Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): British Heart Foundation Introduction Automated classification of arrhythmias in ECGs is becoming increasingly important. Publicly available ECG datasets have been widely used by the research community to create …

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Lowest peak central venous pressure correlates with highest invasive arterial blood pressure as a method for optimising AV delay in post-surgical temporary pacing

Alexander Tindale, Ioana Crețu, Mark Mason, Dárrel P. Francis

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): British Heart Foundation. Background Atrioventricular (AV) delay optimisation has been performed using a variety of methods, including doppler outflow and alternating blood pressure algorithms. Patients after …

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Variation in optimal hemodynamic atrio‐ventricular delay of biventricular pacing with different endocardial left ventricular lead locations using precision hemodynamics

Charles Butcher, Emily Cantor, Afzal Sohaib, Matthew Shun‐Shin et autres

Abstract Introduction It is not known whether the optimal atrioventricular (AVopt) delay varies between left ventricular (LV) pacing site during endocardial biventricular pacing (BiVP) and may therefore needs consideration. Methods We assessed the hemodynamic AVopt in patients with chronic heart failure undergoing …

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Techniques to aid prediction of pacing dependence at 30 days in patients requiring pacemaker implantation after cardiac surgery

Ioana Crețu, Alexander Tindale, Maysam Abbod, Ashraf W. Khir et autres

Permanent pacemaker (PPM) implantation occurs in up to 5 % of patients after cardiac surgery but there is little consensus on how long to wait between surgery and PPM insertion. Predicting the likelihood of a patient being pacing dependent 30 days after …

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UG06 Implementation of targeted testing and resistance-guided therapy for Mycoplasma genitalium in a large urban STI service

Eilidh Mitchell, Omar Amin, Mark Mason, Rory Gunson et autres

Introduction Scaling up testing and resistance-guided management for M. genitalium requires attention to case selection and timely and accurate results management. We describe our experience of biomedical scientist-initiated test requesting. Methods We implemented M. genitalium testing in our local laboratory from 28/6/2021 …

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The acute haemodynamic response with endocardial biventricular pacing: comparing RV paced and LBBB patients

Érika Cantor, C Butcher, JJ Chow, S M A Sohaib et autres

Abstract Funding Acknowledgements Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Boston Scientific Background A third of patients that receive cardiac resynchronisation (CRT) are non-responders. Predictors of positive response include broader QRS duration, non-ischaemic aetiology and sinus rhythm, but …

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