Gregory W. Sawyer

Abstract A013: TAp63-Regulated Oncogenic LncRNAs (TROLLs) as novel therapeutic targets in high grade serous ovarian cancer

Ashley Lui, Marco Napoli, Julia Nowak, Mayayi Izzo et autres

Abstract High-grade serous ovarian cancer (HGSOC) is the most common and malignant type of ovarian cancer. Even though roughly 85% of patients achieve remission after initial surgical debulking and chemotherapy, four out of five HGSOC patients will experience disease recurrence, resulting in …

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Abstract A056: Patient avatar models for ovarian cancer: Predicting patient response to treatment

Yuxi Zhou, Alfonso Pepe, Ryan Smolchek, Jack E. Famiglietti et autres

Abstract Background: High-grade serous ovarian cancer (HGSOC) remains a leading cause of gynecologic cancer-related mortality, with limited treatment options. Although initial remission is often achieved through surgery and chemotherapy, disease recurrence is common. Existing preclinical models fail to fully recapitulate the complexity …

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IMMU-63. MESSENGER RNA CHALLENGE PREDICTS CANCER IMMUNOGENICITY AND RESPONSE TO CHECKPOINT INHIBITORS

Paul Castillo, Elizabeth Ogando‐Rivas, Hilary Geffrard, Alfonso Pepe et autres

Abstract BACKGROUND Checkpoint inhibition has emerged as a promising cancer therapeutic approach. Checkpoint inhibitors (CIs) function by overcoming the adaptive T cell exhaustion induced by solid tumor microenvironment including brain tumors, particularly in the neoadjuvant setting. Unfortunately, not every patient who receives …

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48 THE ADHESIN GENE FIMH IS IMPLICATED IN ADHERENT INVASIVE E. COLI INDUCED INFLAMMATION AND COLORECTAL CANCER DEVELOPMENT

Qin Yu, Nicky Craig, Rachel C. Newsome, M. C. Carreño Hernández et autres

Structural Evolution and Spatial Heterogeneity in Mucin Layers

Tristan T. Hormel, Tapomoy Bhattacharjee, Christopher S. O’Bryan, Gregory W. Sawyer et autres

Full-Field Deformation Measurements in Liquid-like-Solid Granular Microgel Using Digital Image Correlation

Alexander McGhee, Alexander I. Bennett, Peter Ifju, Gregory W. Sawyer et autres

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Mucin Production Dynamics at the Surface of Corneal Epithelial Cells

Tristan T. Hormel, Tapomoy Bhattacharjee, Angela A. Pitenis, Juan Manuel Urueña et autres

Using In Vitro Mutagenesis to Characterize Structure-Function Relationships in G Protein-Coupled Receptors

Gregory W. Sawyer, Frederick J. Ehlert

The use of in vitro mutagenesis to characterize structure-function relationships in G protein-coupled receptors has led to the identification of specific amino acid residues that contribute to ligand binding, G protein coupling, and receptor folding. Mutagenesis is commonly used to change or …

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Use of membrane permeable ligands as pharmacological chaperones to rescue the plasma membrane expression of a mutant muscarinic M 1 receptor

Gregory W. Sawyer, Crystal A. Shults

In this investigation, we determined whether membrane permeable muscarinic receptor selective agonists, antagonists, and allosteric ligands cause a mutant M 1 muscarinic receptor to traffic from ER to the plasma membrane of CHO cells. This receptor, M 1LL/AA , possesses a L430A/L431A …

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Force transmission through intercellular fluid transfer

Steven M. Zehnder, Jolie Breaux, Alison C. Dunn, Gregory W. Sawyer et autres

A Novel Method for Determining the Kinetics of G Protein-Coupled Receptor Plasma Membrane Expression

Gregory W. Sawyer

A new approach for characterizing the plasma membrane delivery of G protein-coupled receptors is described in this chapter. This approach uses an existing technology, the regulated secretion/aggregation technology (RPD ™ ), to cause the accumulation of G protein-coupled receptors in the ER …

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Comparison of the kinetics and extent of muscarinic M1–M5 receptor internalization, recycling and downregulation in Chinese hamster ovary cells

Arunkumar Thangaraju, Gregory W. Sawyer

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