Qiangcheng Zeng

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong et autres

Peptides combine the favorable pharmacokinetics of small molecules with the high specificity of biologics, making them promising therapeutics. Incorporating non-canonical amino acids (ncAAs) further enhances drug-like properties, yet modeling remains challenging due to chemically modified residues and combinatorial sequence diversity. Here, we …

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Integrated High-Purity Sialic Acid Production Process Using Multi-Stage Membrane Filtration Coupled with Resin Adsorption

Xingxing Yu, Zihan Zhai, Qiangcheng Zeng, Jiajia Chen et autres

This study presents a novel, integrated membrane–resin hybrid platform for the high-efficiency purification of N-acetylneuraminic acid (sialic acid, NANA) from complex microbial fermentation broths. By synergistically combining four sequential stages—ceramic microfiltration (50 nm), ultrafiltration (3 kDa), nanofiltration (150 Da), and dual-resin purification …

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A New Taxonomic Placement of Cochylis discerta (Lepidoptera: Tortricidae) to Falseuncaria Supported by Congruent Mitogenomic and Morphological Evidence

Yinghui Sun, Huifeng Zhao, John W. Brown, Qiangcheng Zeng et autres

ABSTRACT In the realm of taxonomic research focused on the Lepidoptera order, our investigation provides evidence supporting the potential reclassification of Cochylis discerta Razowski. The complete mitochondrial genomes of four species of Cochylini were newly sequenced: Aethes alatavica (Danilevskij), Cochylis discerta Razowski, …

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Effects of continuous cropping on soil metabolomics and rhizosphere bacterial communities in Panax quinquefolius L.

Jian Bo Song, Qing He, Xiliang Song, Qiangcheng Zeng

Introduction Continuous cropping obstacles (CCOs) due to long-term monoculture have emerged as a pervasive challenge in contemporary agriculture worldwide. The practices of CCOs are the primary causes of restraining the Panax quinquefolius L. ( P. quinquefolius ) growth, whereas its underlying microbial …

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CircCdh7 induces astrogliosis and neuroinflammation to trigger hypertensive effects in the rostral ventrolateral medulla

Shuai Zhang, Tengteng Dai, Bingjie Zhao, Xueping Wang et autres

BACKGROUND: The rostral ventrolateral medulla (RVLM) is a critical vasomotor center that plays a pivotal role in the pathogenesis of hypertension. However, the involvement of circular RNAs (circRNAs) in this nucleus in blood pressure (BP) regulation remains incompletely understood. METHODS: In this …

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Checklist of the Tribe Eucosmini Obraztsov, 1946 (Lepidoptera: Tortricidae: Olethreutinae) from Taiwan

Yinghui Sun, John W. Brown, Ming Liu, Qiangcheng Zeng et autres

This study presents an updated and detailed inventory of the tortricid tribe Eucosmini found in Taiwan Province, China, highlighting 26 genera and 53 species. Several taxonomic novelties were revealed: The genus Coenobiodes is newly recorded for Taiwan Province, Hermenias semicurva is newly …

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m6A reader YTHDF3 elicits hypertensive effects by degrading XRCC1 mRNA in the rostral ventrolateral medulla

Shuai Zhang, Xueping Wang, Bingjie Zhao, Tengteng Dai et autres

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Resveratrol reduces RVLM neuron activity via activating the AMPK/Sirt3 pathway in stress-induced hypertension

Linping Wang, Tian‐Feng Liu, Tengteng Dai, Xin Deng et autres

Neuronal hyperexcitability in the rostral ventrolateral medulla (RVLM), driven by oxidative stress, plays a crucial role in stress-induced hypertension (SIH). While resveratrol (RSV) is known for its antioxidant properties, its effects on RVLM neurons in SIH remain unclear. We investigated this using …

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Peony Seed Oil Inhibited Neuroinflammation by PPAR / RXR Signaling Pathway in D‐Gal Induced Mice

Tianyu Zhang, Ying Zhang, Andong Ji, Runjia Shi et autres

ABSTRACT Essential fatty acids could regulate inflammation, especially n‐3 PUFA (n‐3 polyunsaturated fatty acids), which are considered to have a protective effect to inhibit neuroinflammation. Peony seed oil is one of the most abundant n‐3 PUFAs in oils. but the mechanism of …

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Dynamic modeling of antibody repertoire reshaping in response to viral infections

Zhaobin Xu, Qingzhi Peng, Junxiao Xu, Hongmei Zhang et autres

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A mathematical model simulating the adaptive immune response in various vaccines and vaccination strategies

Zhaobin Xu, Jian Hui Song, Hongmei Zhang, Zhenlin Wei et autres

Vaccination has been widely recognized as an effective measure for preventing infectious diseases. To facilitate quantitative research into the activation of adaptive immune responses in the human body by vaccines, it is important to develop an appropriate mathematical model, which can provide …

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A Mathematical Model Simulating the Adaptive Immune Response in Various Vaccines and Vaccination Strategies

Zhaobin Xu, Jian Hui Song, Hongmei Zhang, Zhenlin Wei et autres

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