Chimène Asta

ChemInform Abstract: Combination of Enzyme‐ and Lewis Acid‐Catalyzed Reactions: A New Method for the Synthesis of 6,7‐Dihydrobenzofuran‐4(5H)‐ones Starting from 2,5‐Dimethylfuran and 1,3‐Cyclohexanediones.

Chimène Asta, D. Schmidt, Juergen Conrad, Wolfgang U. Frey et autres

Abstract The (Z)‐hexenedione (I), previously obtained by laccase‐promoted cleavage of 2,5‐dimethylfuran undergoes Gd‐catalyzed reaction with diones (II) to form dihydrobenzofurans (III).

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The first enzymatic Achmatowicz reaction: selective laccase-catalyzed synthesis of 6-hydroxy-(2H)-pyran-3(6H)-ones and (2H)-pyran-2,5(6H)-diones

Chimène Asta, D. Schmidt, Jürgen Conrad, Bernhard Förster-Fromme et autres

The laccase-catalyzed oxidation of (5-alkylfuran-2-yl)carbinols using aerial oxygen as an oxidant selectively affords 6-hydroxy-(2H)-pyran-3(6H)-ones with yields up to 90%. With suitable substituted furan-2-yl carbinols as substrates the procedure allows the efficient preparation of (2H)-pyran-2,5(6H)-diones in a single step.

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Combination of enzyme- and Lewis acid-catalyzed reactions: a new method for the synthesis of 6,7-dihydrobenzofuran-4(5H)-ones starting from 2,5-dimethylfuran and 1,3-cyclohexanediones

Chimène Asta, D. Schmidt, Jürgen Conrad, Wolfgang U. Frey et autres

The Lewis acid-catalyzed domino 1,2-addition/1,4-addition/elimination between (Z)-3-hexene-2,5-dione and 1,3-dicarbonyls delivers 3-methyl-6,7-dihydrobenzofuran-4(5H)-ones exclusively with yields up to 82%. The combination of this new process with the laccase-catalyzed formation of (Z)-3-hexene-2,5-dione by oxidative cleavage of 2,5-dimethylfuran allows for the synthesis of 6,7-dihydrobenzofuran-4(5H)-ones starting directly …

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CCDC 926712: Experimental Crystal Structure Determination

Chimène Asta, D. Schmidt, Jürgen Conrad, Wolfgang Frey et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 926713: Experimental Crystal Structure Determination

Chimène Asta, D. Schmidt, Jürgen Conrad, Wolfgang Frey et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

ChemInform Abstract: Laccase‐Catalyzed Stereoselective Oxidative Ring Opening of 2,5‐Dialkylfurans into 2‐Ene‐1,4‐diones Using Air as an Oxidant.

Chimène Asta, Juergen Conrad, Sabine Mika, Uwe Beifuß

Abstract The laccase‐catalyzed ring cleavage of symmetrically and asymmetrically substituted 2,5‐dialkylfurans (I) yields (Z)‐enediones (II) in a diastereoselective manner.

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Laccase-catalyzed stereoselective oxidative ring opening of 2,5-dialkylfurans into 2-ene-1,4-diones using air as an oxidant

Chimène Asta, Jürgen Conrad, Sabine Mika, Uwe Beifuß

The laccase-catalyzed ring opening of 2,5-dimethylfuran using air as an oxidant stereoselectively yields (Z)- or (E)-3-hexene-2,5-dione depending on the mediator employed: with TEMPO the (Z)-3-hexene-2,5-dione is formed, while a combination of TEMPO and violuric acid gives (E)-3-hexene-2,5-dione. The (Z)-selective ring cleavage was …

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Cloning, expression and characterisation of CYP102A7, a self-sufficient P450 monooxygenase from Bacillus licheniformis

Matthias Dietrich, Sabine Eiben, Chimène Asta, Tuấn Bùi Lê Anh et autres

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