Accès ouvert
2026
article
OpenAlex
Linda Petrone, Saeid Najafi-Fard, Anna Maria Gerarda Altera, Alessandra Aiello et autres
OBJECTIVE: Type 2 diabetes (T2D) increases the risk of tuberculosis (TB) and TB severity; however, its effects on B-cells in the TB-T2D syndemic are not fully understood. METHODS: We evaluated by flow cytometry, the distribution of circulating B-cell subsets in patients with …
it, us, am, gb, nl
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Elisa Petruccioli, Tonino Alonzi, Assunta Navarra, Anna Maria Gerarda Altera et autres
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health threat. Approximately one-quarter of the world’s population has an Mtb-specific immune response and are classified as having tuberculosis infection (TBI), with a lifelong 5–10% risk of developing TB disease. This …
it, dk, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Alessandra Aiello, Assunta Navarra, Shalom Haggiag, Serena Ruggieri et autres
Background: The COVID-19 pandemic highlighted challenges in managing patients with multiple sclerosis (PwMS), as disease-modifying therapies (DMTs) can interfere with immune responses to infections and vaccines. Objective: This study investigates the spike-specific T-cell response after the third dose of mRNA COVID-19 vaccines …
it, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Chiara Farroni, Anna Maria Gerarda Altera, Andrea Salmi, Valentina Vanini et autres
Background Subjects with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis, with tuberculosis infection (TBI), have a high probability of progressing to tuberculosis disease (TB). We aim to characterize the impact of IMID on the immune response to M. tuberculosis (Mtb) in …
it, us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Saeid Najafi Fard, Chiara Farroni, Linda Petrone, Anna Maria Gerarda Altera et autres
Objective Cysteamine, a drug approved to treat cystinosis, has been proposed as a host-directed therapy for M. tuberculosis (Mtb) and SARS-CoV-2. The impact of cysteamine on the immune responses has not been fully investigated. We aimed to in vitro evaluate the immunomodulatory …
it
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Linda Petrone, Daniela Peruzzu, Anna Maria Gerarda Altera, Andrea Salmi et autres
Background Identifying stage-specific antigens is essential for developing tuberculosis (TB) diagnostics and vaccines. In a low TB endemic country, we characterized, the Mycobacterium tuberculosis (Mtb)-specific immune response to a pool of Mtb-derived epitopes (ATB116), demonstrated as associated with TB disease. Methods In …
it, us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Alessandra Aiello, Serena Ruggieri, Assunta Navarra, Carla Tortorella et autres
This study investigated the incidence and severity of SARS-CoV-2 breakthrough infections (BIs) and the time to swab reversion in patients with multiple sclerosis (PwMS) after the booster dose of COVID-19 mRNA vaccines. We enrolled 64 PwMS who had completed the three-dose mRNA …
it
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Serena Ruggieri, Alessandra Aiello, Carla Tortorella, Assunta Navarra et autres
This study characterizes antibody and T-cell immune responses over time until the booster dose of COronaVIrus Disease 2019 (COVID-19) vaccines in patients with multiple sclerosis (PwMS) undergoing different disease-modifying treatments (DMTs). We prospectively enrolled 134 PwMS and 99 health care workers (HCWs) …
it
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Alessandra Aiello, Andrea Coppola, Serena Ruggieri, Chiara Farroni et autres
Background The decline of humoral response to COVID-19 vaccine led to authorise a booster dose. Here, we characterised the kinetics of B-cell and T-cell immune responses in patients with multiple sclerosis (PwMS) after the booster dose. Methods We enrolled 22 PwMS and …
it
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Chiara Farroni, Alessandra Aiello, Bruno Laganà, Elisa Petruccioli et autres
Objectives To characterize the kinetics of humoral and T-cell responses in rheumatoid arthritis (RA)-patients followed up to 4-6 weeks (T3) after the SARS-CoV-2 vaccine booster dose. Methods Health care workers (HCWs, n = 38) and patients with RA (n = 52) completing …
it
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Saeid Najafi Fard, Elisa Petruccioli, Chiara Farroni, Linda Petrone et autres
Objective Several therapies with immune-modulatory functions have been proposed to reduce the overwhelmed inflammation associated with COVID-19. Here we investigated the impact of IL-10 in COVID-19, through theex-vivoassessment of the effects of exogenous IL-10 on SARS-CoV-2-specific-response using a whole-blood platform. Methods Two …
it
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Alessandra Aiello, Adriano Grossi, Silvia Meschi, Marcello Meledandri et autres
Objective: To better define the immunopathogenesis of COVID-19, the present study aims to characterize the early immune responses to SARS-CoV-2 infection in household contacts of COVID-19 cases. In particular, innate, T- and B-cell specific responses were evaluated over time. Methods: Household contacts …
it
(code pays fourni par la source)