Joshua Michael Gulley

Ontogeny of Catechol-O-Methyltransferase Expression in the Rat Prefrontal Cortex: Effects of Methamphetamine Exposure

Lauren K. Carrica, Joshua Michael Gulley

INTRODUCTION: Repeated use of methamphetamine (METH) is known to dysregulate the dopaminergic system and induce long-lasting changes in behavior, which may be influenced by sex and age of exposure. Catechol-o-methyltransferase (COMT) is an enzyme that is involved in the breakdown of catecholamines, …

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Ontogeny of catechol-o-methyltransferase expression in the rat prefrontal cortex: effects of methamphetamine exposure

Lauren K. Carrica, Joshua Michael Gulley

Abstract Repeated use of methamphetamine (METH) is known to dysregulate the dopaminergic system and induce long-lasting changes in behavior, which may be influenced by sex and age of exposure. Catechol-o-methyltransferase (COMT) is an enzyme that is involved in the breakdown of catecholamines, …

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HAIP therapy with antibody-drug conjugate delivery of IL-12: early results from a phase II study

Alyssa V. Eade, Cecilia Monge, Cathleen E Hannah, Edward C. Smith et autres

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The effects of moderate alcohol and THC co-use during male and female rat adolescence on AKT-GSK3ß signaling in adulthood

Linyuan Shi, Chan Young Choi, Lauren K. Carrica, Nu‐Chu Liang et autres

Alcohol and cannabis are often taken in combination, and extensive co-use has been linked to enduring changes in cognitive and metabolic functioning. The underlying mechanisms for these effects are unclear, but we recently demonstrated that co-administration of ethanol and delta-9-tetrahydrocannbinol (THC) to …

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Timing of Methamphetamine Exposure during Adolescence Differentially Influences Parvalbumin and Perineuronal Net Immunoreactivity in the Medial Prefrontal Cortex of Female, but Not Male, Rats

Amara S. Brinks, Lauren K. Carrica, Dominic J. Tagler, Joshua Michael Gulley et autres

INTRODUCTION: Adolescence involves significant reorganization within the medial prefrontal cortex (mPFC), including modifications to inhibitory neurotransmission that may be mediated through parvalbumin (PV) interneurons and their surrounding perineuronal nets (PNNs). These developmental changes, which can result in increased PV neuron activity in …

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The role of sex and drug use during adolescence in determining the risk for adverse consequences of amphetamines

Lauren K. Carrica, Joshua Michael Gulley

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Effects of combined exposure to ethanol and delta-9-tetrahydrocannabinol during adolescence on synaptic plasticity in the prefrontal cortex of Long Evans rats

Linyuan Shi, Shuo Kang, Chan Young Choi, Brynn L. Noonan et autres

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Timing of methamphetamine exposure during adolescence differentially influences parvalbumin and perineuronal net immunoreactivity in the medial prefrontal cortex of female, but not male, rats

Amara S. Brinks, Lauren K. Carrica, Dominic J. Tagler, Joshua Michael Gulley et autres

Adolescence involves significant reorganization within the medial prefrontal cortex (mPFC), including modifications to inhibitory neurotransmission mediated through parvalbumin (PV) interneurons and their surrounding perineuronal nets (PNNs). These developmental changes, which result in increased PV neuron activity in adulthood, may be disrupted by …

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Effects of combined exposure to ethanol and delta-9-tetrahydrocannabinol during adolescence on synaptic plasticity in the prefrontal cortex of Long Evans rats

Linyuan Shi, Shuo Kang, Chan Young Choi, Brynn L. Noonan et autres

ABSTRACT Significant exposure to alcohol or cannabis during adolescence can induce lasting disruptions of neuronal signaling in brain regions that are later to mature, such as the medial prefrontal cortex (mPFC). Considerably less is known about the effects of alcohol and cannabis …

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Effects of combined use of alcohol and delta-9-tetrahydrocannibinol on working memory in Long Evans rats

Lauren K. Carrica, Chan Young Choi, Francis A. Walter, Brynn L. Noonan et autres

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Effects of combined use of alcohol and delta-9-tetrahydrocannibinol on working memory in Long Evans rats

Lauren K. Carrica, Chan Young Choi, Francis A. Walter, Brynn L. Noonan et autres

Abstract The increase in social acceptance and legalization of cannabis over the last several years is likely to increase the prevalence of its co-use with alcohol. In spite of this, the potential for effects unique to co-use of these drugs, especially in …

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Adolescent drug addiction

Joshua Michael Gulley, Sari Izenwasser

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