James Liao

A Self-Administered, Digitized Approach to Quantifying the Cardinal Motor Symptoms in Parkinson’s Disease

Mandy Miller Koop, Colin Waltz, Andrew S. Bazyk, B Lapin et autres

Many people with Parkinson’s disease (PwPD) lack optimal care due to limited access to neurologists and a reliance on subjective rating scales for treatment decisions. The Ceraxis Insight platform was designed to provide quantitative measures of the cardinal motor symptoms of Parkinson’s …

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Integrating Eye Tracking and Inertial Sensing for Enhanced Freezing of Gait Detection in Parkinson's Disease

Christopher L. Pulliam, Jinxin Chen, James Liao

Freezing of gait (FOG), a disabling symptom in Parkinson's disease, presents a major challenge for wearable classification algorithms that struggle to distinguish freezes from voluntary stops. To address this ambiguity, we evaluated whether incorporating eye-gaze kinematics could improve classification accuracy compared to …

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A Pilot Randomized Trial of Physical Therapy with Atomoxetine or Methylphenidate for Gait and Balance Impairment in Parkinson’s Disease (The TAME-PD Study)

Saar Anis, Xiomara García, Xin Yu, Tanaporn Rasameesoraj et autres

A novel methodological approach to understanding the cortical and subcortical effects of aerobic exercise in Parkinson’s disease

Mandy Miller Koop, Anson B. Rosenfeldt, Visar Berki, Andrew S. Bazyk et autres

Introduction: Aerobic exercise mitigates symptoms of Parkinson's disease (PD) and may slow disease progression; however, the neural mechanisms underlying these improvements are not well understood. In this study, we discuss the methodology for simultaneously recording local field potentials (LFP) from the subthalamic …

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Corrigendum to “Reconstructing time-domain data from discontinuous Percept™ PC and RC output using external data acquisition and linear filtering” [J. Neurosci. Methods 424 (2025) 110566]

Jinxin Chen, Mandy Miller Koop, Kenneth B. Baker, Jay L. Alberts et autres

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Reconstructing time-domain data from discontinuous Percept™ PC and RC output using external data acquisition and linear filtering

Jinxin Chen, Mandy Miller Koop, Kenneth B. Baker, Jay L. Alberts et autres

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Integrating Eye Tracking and Inertial Sensing for Enhanced Freezing of Gait Detection in Parkinson's Disease

Christopher L. Pulliam, Jinxin Chen, James Liao

Freezing of gait, a disabling symptom in Parkinson’s disease, presents a major challenge for wearable classification algorithms that struggle to distinguish pathological freezes from voluntary stops. To address this ambiguity, we evaluated whether incorporating eye-gaze kinematics could improve classification accuracy compared to …

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A Case of Acute-Onset, Refractory Freezing of Gait Following Subthalamic Nucleus Deep Brain Stimulation Adjustment

Brendan Baugher, Ellen M. Walter, Erica Hennigs, Kristen Appleby et autres

Freezing of gait (FoG) is a disabling symptom of Parkinson’s disease (PD) characterized by involuntary cessation/reduction. While deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) effectively treats common PD symptoms such as tremor, its impact on FoG is less clear. Rarely, …

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Utility of synthetic musculoskeletal gaits for generalizable healthcare applications

Yasunori Yamada, Masatomo Kobayashi, Kaoru Shinkawa, Erhan Bilal et autres

Deep-neural-network-based artificial intelligence enables quantitative gait analysis with commodity sensors. However, current gait-analysis models are usually specialized for specific clinical populations and sensor settings due to the limited size and diversity of available datasets. We propose an approach that involves using synthetic …

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An Experimental Approach for Investigating Freezing of Gait in Parkinson’s Disease Using Virtual Reality and Neural Sensing: A Pilot Study

Mandy Miller Koop, Anson B. Rosenfeldt, Kathryn Scelina, Logan Scelina et autres

Freezing of gait (FOG) is a disabling symptom associated with Parkinson's disease (PD). Its understanding and effective treatment is compromised due to the difficulty in reliably triggering FOG in clinical and laboratory environments. The Cleveland Clinic-Virtual Home Environment (CC-VHE) platform was developed …

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Including individuals with Parkinson's disease and deep brain stimulation in rehabilitation trials: feasibility, challenges, and preliminary gait and postural stability results

Anson B. Rosenfeldt, Sara Davidson, Ryan D. Kaya, Elizabeth A. West et autres

BACKGROUND: People with Parkinson's disease (PwPD) who have undergone deep brain stimulation (DBS) surgery have been historically excluded from rehabilitation clinical trials. OBJECTIVE: This project investigated the safety, feasibility, and preliminary efficacy of a dual-task training intervention aimed at improving postural instability …

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Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next

Camila Callegari Piccinin, Saar Anis, Jeryl Ritzi T. Yu, Philippe A. Salles et autres

Knowledge of the genetic factors in normal pressure hydrocephalus (NPH) is rapidly evolving, with significant advances in recent years. We conducted a systematic review examining genetic contributions to NPH risk. Ovid Embase, Ovid Medline, Web of Science, and Cochrane Central were searched …

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