Ganyuan Xiao

Abstract 4746: PLB-001, a novel anti-dll3 ADC with topoisomerase 1 inhibitor-based linker-payload for treatment of SCLC

Yingdong Lu, Xin Li, Ganyuan Xiao, Kia Joo Puan et autres

Abstract Delta-like ligand 3 (DLL3) is a promising target for antibody-drug conjugates (ADCs) in the treatment of small cell lung cancer (SCLC) due to its high expression on the cell surface of SCLC cells and minimal expression in normal tissues. With highly …

Abstract 2945: PLB-002 is a novel Claudin 6 antibody-drug conjugate for ovarian cancer and testicular germ cell cancer

Hai‐Tao Pan, Qing Hua Zhang, Ganyuan Xiao, Guangchao Zhang et autres

Abstract Background: Claudin 6 (CLDN6) is a clinically validated target for many solid tumors notably ovarian, endometrial, and testicular cancer. Its expression is restricted to tumor cells and fetal tissues with little or no detectable in normal tissues. As such, CLDN6 represents …

CCDC 2117934: Experimental Crystal Structure Determination

Ganyuan Xiao, Gerard Su, Alexandra M. Z. Slawin, Nicholas James Westwood

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2117933: Experimental Crystal Structure Determination

Ganyuan Xiao, Gerard Su, Alexandra M. Z. Slawin, Nicholas James Westwood

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

From Biomass to the Karrikins via Selective Catalytic Oxidation of Hemicellulose‐Derived Butyl Xylosides and Glucosides

Ganyuan Xiao, Gerard Su, Alexandra M. Z. Slawin, Nicholas James Westwood

Abstract Members of the karrikin family of bioactive small molecules are known to promote germination of a range of plants following large scale fires. As a result, they are relevant and interesting compounds. This report describes their synthesis from a biomass‐derived product …

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Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design

Ganyuan Xiao, M.S. Alphey, Fanny Tran, Lisa Pirrie et autres

The monosaccharide l-Rhamnose is an important component of bacterial cell walls. The first step in the l-rhamnose biosynthetic pathway is catalysed by glucose-1-phosphate thymidylyltransferase (RmlA), which condenses glucose-1-phosphate (Glu-1-P) with deoxythymidine triphosphate (dTTP) to yield dTDP-d-glucose. In addition to the active site …

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Cleavage of Organosolv Lignin to Phenols Using Nitrogen Monoxide and Hydrazine

Laura Elena Hofmann, Lisa‐Marie Altmann, Oliver Fischer, Lea Prusko et autres

From the variety of methods known for the depolymerization of organosolv lignin, a broad range of diversely substituted aromatic compounds are available today. In the present work, a novel two-step reaction sequence is reported, which is focused on the formation of phenols. …

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2-(3-Hydroxybenzyl)benzo[d]isothiazol-3(2H)-one Mannich base derivatives as potential multifunctional anti-Alzheimer’s agents

Yuxi He, Ganyuan Xiao, Guangjun Yu, Qing Song et autres

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Data in Brief

Ganyuan Xiao, Fanny Tran, M.S. Alphey, Lisa Pirrie et autres

Data on allosteric P. aeruginosa RmlA inhibitor following SAR studies on the unexplored hydrophobic pocket at this second site occupied by the N1-substituent.

PhD thesis raw data

Ganyuan Xiao

Include all the raw data of my thesis

Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design

Ganyuan Xiao, M.S. Alphey, Fanny Tran, Lisa Pirrie et autres

Raw data for next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design.

Copper‐Mediated Conversion of Complex Ethers to Esters: Enabling Biopolymer Depolymerisation under Mild Conditions

Ganyuan Xiao, James R. D. Montgomery, Christopher S. Lancefield, Isabella Panovic et autres

Abstract Selective processing of the β‐O‐4 unit in lignin is essential for the efficient depolymerisation of this biopolymer and therefore its successful integration into a biorefinery set‐up. An approach is described in which this unit is modified to incorporate a carboxylic ester …

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