Shahrnaz Kemal

TPPP Forms Liquid Condensates and Aggregates in Multiple System Atrophy

Shahrnaz Kemal, Hunter S. Richardson, Thomas S. McAlear, Andrii Kopach et autres

ABSTRACT Oligodendrocytes have elaborate arbors of microtubules that extend toward axons and spiral around myelin sheaths. Oligodendrocytes rely on satellite organelles called Golgi outposts to nucleate new microtubules at sites far from the cell body. We now show that the Golgi outpost …

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ER and Golgi trafficking in axons, dendrites, and glial processes

Shahrnaz Kemal, Hunter S. Richardson, Eric D. Dyne, Meng‐meng Fu

Both neurons and glia in mammalian brains are highly ramified. Neurons form complex neural networks using axons and dendrites. Axons are long with few branches and form pre-synaptic boutons that connect to target neurons and effector tissues. Dendrites are shorter, highly branched, …

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Poloxamer-188 Exacerbates Brain Amyloidosis, Presynaptic Dystrophies, and Pathogenic Microglial Activation in 5XFAD Mice

Antonio Di Meco, Shahrnaz Kemal, Jelena Popović, Sidhanth Chandra et autres

BACKGROUND: Alzheimer's disease (AD) is initiated by aberrant accumulation of amyloid beta (Aβ) protein in the brain parenchyma. The microenvironment surrounding amyloid plaques is characterized by the swelling of presynaptic terminals (dystrophic neurites) associated with lysosomal dysfunction, microtubule disruption, and impaired axonal …

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Death by microglia

Shahrnaz Kemal, Robert J. Vassar

The roles of microglia and ApoE in tauopathies, such as Alzheimer's disease, remain elusive. In this issue, Shi et al. (https://doi.org/10.1084/jem.20190980) demonstrate that microglia-mediated innate immunity collaborates with ApoE to drive neurodegeneration and disease progression in a mouse model of tauopathy.

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P1‐163: MOLECULAR MECHANISMS OF THE ALZHEIMER'S RISK GENE UNC5C IN NEURONAL DEATH

Devi Krishna Priya Karunakaran, Katherine Rose Sadleir, Shahrnaz Kemal, Leah K. Cuddy et autres

Alzheimer's disease (AD) is characterized by amyloid plaques, neurofibrillary tangles, and synaptic and neuronal loss. The mechanism of neuron death in AD, however, remains unexplored. Recently, a rare autosomal dominant coding mutation, T835M, was discovered in the Un-coordinated 5c (Unc5c) netrin receptor …

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Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages

David J. Doobin, Shahrnaz Kemal, Tiago J. Dantas, Richard B. Vallee

Microcephaly is a cortical malformation disorder characterized by an abnormally small brain. Recent studies have revealed severe cases of microcephaly resulting from human mutations in the NDE1 gene, which is involved in the regulation of cytoplasmic dynein. Here using in utero electroporation …

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Distinct Roles for Dynein Regulatory Proteins NudE and NudEL in Brain Development

Shahrnaz Kemal

The development of the mammalian neocortex requires the careful balancing of proliferation, migration, and differentiation. The cellular machinery coordinating these events includes molecular motor proteins such as dynein. Regulation of dynein activity is particularly important, since it is the major microtubule minus-end …

Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells

Jin‐Wu Tsai, Wei-Nan Lian, Shahrnaz Kemal, Arnold R. Kriegstein et autres

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LIS1 and Nude Permit Multiple Dynein Motors to Cooperate to Transport High Loads

Richard J. McKenney, Micahel Vershinin, Ambarish Kunwar, Shahrnaz Kemal et autres

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Dynamics of Dynamin during Clathrin Mediated Endocytosis in PC12 Cells

Joshua Zachary Rappoport, Katherine P. Heyman, Shahrnaz Kemal, Sanford M. Simon

BACKGROUND: Members of the dynamin super-family of GTPases are involved in disparate cellular pathways. Dynamin1 and dynamin2 have been implicated in clathrin-mediated endocytosis. While some models suggest that dynamin functions specifically at the point of vesicle fission, evidence also exists for a …

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Dynamics of clathrin and adaptor proteins during endocytosis

Joshua Zachary Rappoport, Shahrnaz Kemal, Alexandre Benmerah, Sanford M. Simon

The endocytic adaptor complex AP-2 colocalizes with the majority of clathrin-positive spots at the cell surface. However, we previously observed that AP-2 is excluded from internalizing clathrin-coated vesicles (CCVs). The present studies quantitatively demonstrate that AP-2 disengages from sites of endocytosis seconds …

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