Mariona Pascal

Hyperprogression Upon Cemiplimab Alone or With Short Course Chemotherapy in PD-L1 ≥ 50% Non–small Cell Lung Cancer: A Biomarker Guided Multicenter International Phase 2 Trial—HYPERBOLIC Study

Ludovica Mollica, Elena Tassi, Anna Copaloni, Irene De Simone et autres

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Melittin in A llergo O ncology: From Honey Bee Venom to Anti‐Cancer Therapeutic Innovation—An EAACI Position Paper

Teodorikez Wilfox Jiménez‐Rodriguez, Luljeta Ahmetaj, Teresa Alfaya, Elisa Boni et autres

Honey bee venom (HBV) represents a unique interface between allergy and oncology, exemplifying how allergen-derived molecules can be repurposed as anti-cancer agents. Melittin, the principal component of HBV, accounts for 40%-50% of its dry weight and is responsible for most of its …

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Sensitization to Blomia tropicalis Across Climatic Zones: A Comparison Between Mediterranean and Tropical Regions

David Calzada, Joan Bartra, Carlos Serrano, S Riggioni et autres

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Biomarkers of Tolerance to Baked Milk in Cow’s Milk–Allergic Children at High Risk of Anaphylaxis

Carmen Riggioni, E Poyatos, Rosa Jiménez‐Feijoo, M. Piquer et autres

BACKGROUND AND OBJECTIVES: Consuming baked milk (BM) may accelerate tolerance in cow's milk-allergic (CMA) children. In high-risk patients, controlled BM-based oral food challenge (BM-OFC) is recommended, as the benefits can outweigh the risks of a prolonged exclusion diet. Objectives: To identify predictive …

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An mRNA-delivered consensus allergen induces a neutralizing IgG response against food and pollen allergens

Mark Møiniche, K. Johansen, Jorge Parrón-Ballesteros, Josefine K. Corneliussen et autres

Cross-allergies affect a significant proportion of the population, and contribute to detrimental health and socioeconomic impacts, yet allergen immunotherapies often target a single allergen source disregarding cross-reactive allergens from other sources. Here we introduce an immunization approach developed for improved desensitization in …

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ICLA-Compliant Validation of Flow Cytometry-Based Basophil Activation Test: Linearity, Precision, and Matrix Comparison

Silvia Calvo Serrano, Clara Lebrón-Martín, María del Carmen Martín-Astorga, María Queralt Salas et autres

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Asthma, Infections and Immunodeficiency

Alberto García de la Fuente, Ebymar Arismendi, Mariona Pascal, César Picado

The relationship between asthma, infections, and immunodeficiencies is complex and affects disease progression. Immune deficiencies can occur independently or because of the inflammatory processes associated with asthma. Early viral infections like respiratory sinticial virus and rhinovirus trigger asthma attacks, while bacteria such …

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Comments to Reply to “Differences in Molecular Sensitization Profiles Between Spanish and Latin American Mite-Allergic Patients”

David Calzada, Joan Bartra, Carlos Serrano, S Riggioni et autres

Table.Latest studies from 2020 to 2025regarding D. pteronyssinus sensitizations in Spain.Green intensity refers to the prevalence to molecular allergen in each study.Reference Approach N patients included Region of study D. pteronyssinus molecular allergens Prevalence % IgEs levels KUA/L Relation between sensitization profiles …

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Molecular Signatures and Functional Pathways of Human Monocytes and Macrophages in Allergy: An EAACI AllergoOncology Scoping Review

Rodolfo Bianchini, Andrea Escolar‐Peña, Vanda Pick, Aurélie Poli et autres

AllergoOncology explores the intersection of allergic diseases and cancer, focusing on shared immune mechanisms. While monocytes and macrophages are extensively studied in cancer, their roles in allergic diseases remain underexplored. To address this gap, we conducted a scoping review to systematically characterize …

Asthma, Infections and Immunodeficiency

Alberto García, Ebymar Arismendi, Mariona Pascal, César Picado

The relationship between asthma, infections, and immunodeficiencies is complex and affects disease progression. Immune deficiencies can occur independently or because of the inflammatory processes associated with asthma. Early viral infections like respiratory sinticial virus and rhinovirus trigger asthma attacks, while bacteria such …

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Supplementary Table 13 from Microbiota Shape Metabolic and Immune Determinants of CAR-T Therapy and Correlate with Outcomes in Myeloma

Mireia Uribe‐Herranz, Aina Oliver‐Caldés, Neus Martínez-Micaelo, Marta Español‐Rego et autres

SCFA evaluation in serum of MM patients from the first cohort at the apheresis day, using gas chromatography-mass spectrometry methodology

Supplementary Figure 24 from Microbiota Shape Metabolic and Immune Determinants of CAR-T Therapy and Correlate with Outcomes in Myeloma

Mireia Uribe‐Herranz, Aina Oliver‐Caldés, Neus Martínez-Micaelo, Marta Español‐Rego et autres

Supplementary Figure S24 shows the association between alpha diversity and clinical outcomes, specifically presenting Kaplan-Meier curves for progression-free survival (PFS) and overall survival (OS). These curves compare patients with high versus low alpha diversity, including 95% confidence intervals and risk tables. Statistical …