Mengmeng Niu

Development and validation of an in vitro permeation test method for rectal mesalamine suppositories

Lingxiao Xie, Megan N. Kelchen, Priyanka Ghosh, Mengmeng Niu et autres

For locally-acting rectal drug products, an assessment of bioequivalence has traditionally necessitated an in vivo comparative clinical endpoint bioequivalence study. By contrast, for locally-acting dermal drug products, an in vitro permeation test (IVPT) using excised skin has become a useful tool to …

us (code pays fourni par la source)

From aroma to off-flavor: Metabolomics unveils the metabolic double-sided nature of traditional Chinese fermented foods

Wei Ruan, Jiayu Liu, Huan-Xin Guo, Shuo Yang et autres

cn (code pays fourni par la source)

Controllable synthesis of montmorillonite/hydrotalcite coatings with high environmental tolerance for passive daytime radiative cooling

Limei Wu, Jiayu Li, Xiaolong Wang, Xinyu Lei et autres

cn (code pays fourni par la source)

WITHDRAWN: 382P A modern DCIS-IBC guide board for postoperative upgrading in ductal carcinoma in situ

Chongyang Duan, Jiang Du, Lei Zhu, Mengmeng Niu et autres

cn (code pays fourni par la source)

Energy stress-induced PKCζ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activation

Junjie Fei, Shuhan Yu, Mingzhe Xu, Yang Liu et autres

Abstract Energy stress triggers the activation of AMP-activated protein kinase (AMPK) via phosphorylation mediated by liver kinase B1 (LKB1). A pivotal step during this process is the translocation of protein kinase C zeta (PKCζ) to the nucleus, where it facilitates the phosphorylation …

cn (code pays fourni par la source)

Study on improving the quality of fermented goat milk and its mechanism by exopolysaccharide-producing Bifidobacterium breve

Mengmeng Niu, Huan-Xin Guo, Xiang‐Chen Meng

The quality of fermented milk can be improved by the exopolysaccharides (EPSs) produced by probiotics. Bifidobacterium breve H4-2 and H9-3 with different EPS production were used as co-fermented probiotics to ferment goat milk in the present study. The physicochemical properties of fermented …

Calcium triggers calmodulin degradation to induce EGF receptor instability and overcome non-small cell lung cancer resistance to tyrosine kinase inhibitors

Luping Li, Xin Lian, Liangping Ding, Rongtian Guo et autres

Epidermal growth factor receptor (EGFR)-targeted therapy by tyrosine kinase inhibitors (TKIs) is the first-line treatment of non-small cell lung cancer (NSCLC). However, EGFR mutation-mediated TKIs resistance remains a major hurdle for NSCLC treatment. This study found the opposite roles of calcium (Ca …

cn (code pays fourni par la source)

Senolytic drugs dasatinib and quercetin promote skin papilloma progression by eliminating senescent cells and impairing immune surveillance

Yue Luo, Xiaoke Xu, Zhiqiang Zhao, Muzhao Xiong et autres

Cellular senescence can function as a cell defense mechanism in halting tumorigenesis. It can also promote tumor progression through senescence-associated secreted phenotype (SASP). Yet how these two opposite pathophysiological processes play a role in the tumor microenvironment (TME) homeostasis remains elusive. Senolytics, …

Atomically Unveiling the Phase Evolution in Weakly Coupled Layered Transition-Metal Phosphorus Trichalcogenide by Chalcogen Doping

Wing Ni Cheng, Ruihuan Duan, Mengmeng Niu, Xiaocang Han et autres

The stacking configuration significantly influences the properties of van der Waals (vdW) layered magnets by dictating crystallographic and magnetic symmetries. Transition-metal phosphorus trichalcogenides (MPX 3, X = S, Se) intrinsically exhibit diverse stacking polytypes, being an optimal platform for magnetic phase engineering. …

cn, sg (code pays fourni par la source)

Immune response to polystyrene microplastics: Regulation of inflammatory response via the ROS-driven NF-κB pathway in zebrafish (Danio rerio)

Jincheng Pei, Shannan Chen, Q Ke, An Ning Pang et autres

cn (code pays fourni par la source)

A Study on Canopy Volume Measurement Model for Fruit Tree Application Based on LiDAR Point Cloud

Na Guo, Ning Xu, Jianming Kang, Guohai Zhang et autres

The accurate measurement of orchard canopy volume serves as a crucial foundation for wind regulation and dosage adjustments in precision orchard management. However, existing methods for measuring canopy volume fail to satisfy the high precision and real-time requirements necessary for accurate variable-rate …

cn (code pays fourni par la source)

Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation

Yong Yi, Guoqiang Wang, Wenhua Zhang, Shuhan Yu et autres

Glucose deprivation, a hallmark of the tumor microenvironment, compels tumor cells to seek alternative energy sources for survival and growth. Here, we show that glucose deprivation upregulates the expression of mitochondrial-cytochrome c oxidase II (MT-CO2), a subunit essential for the respiratory chain …

cn (code pays fourni par la source)