Michael G. White

Selective Organ Site Strategy Versus Debulking in Multiorgan Metastatic Colorectal Cancer: Lessons from the ORCHESTRA Trial

Mikel Madi, Jean-Nicolas Vauthey, Michael G. White

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Impact of Dedicated Care Coordination on Access to Multidimensional Support Services in Young-Onset Colorectal Cancer: A Pragmatic Trial

Jeongyoon Moon, Elaine Maghanoy, Victoria Serpas Higbie, Grace L. Smith et autres

PURPOSE The incidence of young-onset colorectal cancer is increasing, and affected patients experience distinct challenges. Patients with young-onset colorectal cancer may benefit from a dedicated care coordinator who systematically assesses their unmet needs and facilitates referrals to multidimensional specialty support services. METHODS …

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Abstract 4887: Mapping the cellular landscape of intratumoral bacteria in colorectal cancer using single-cell transcriptomics

Ian W. Folkert, Abderrahman Day, Ashish Damania, M. Wong et autres

Abstract Tumor-associated microbes are increasingly investigated across cancer types. In CRC, intratumoral microbes are associated with detrimental treatment responses and clinical outcomes. However, critical gaps remain in understanding how individual cells within the TME respond to microbial presence. Defining these cellular responses …

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Abstract 3953: Assessing the role of immune aggregates as potential biomarkers of immunotherapy response in appendiceal adenocarcinoma (AA) using spatial proteomics

Matt Lastrapes, Eleanor A. Fallon, Brenda Melendez, Bharat Singh et autres

Abstract Appendiceal adenocarcinoma is a rare tumor representing less than 1% of all gastrointestinal malignancies. Unfortunately, over 50% of AA patients present with stage IV disease with many patients being unresectable and with few systemic therapy options. Data from a recent clinical …

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Abstract A027: Mode of presentation and symptoms at diagnosis of early- and late-onset colorectal cancer: a large retrospective AI-powered analysis

Emerik Österlund, Berta Martín-Cullell, Sebastian Correa Cautino, Mahmoud Yousef et autres

Abstract Introduction Early-onset colorectal cancer (EOCRC) is a distinct clinical entity and a rising global challenge. As presentation and symptom patterns at diagnosis have implications for early detection and prognosis, we aimed to characterize differences between EOCRC and late-onset colorectal cancer (LOCRC) …

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Abstract PR013: Distinct Oral Bacterial Signatures in Rectal Cancer Tumors Associated with Age of Onset and Treatment Response

Nadim J. Ajami, Ashish Damania, Abderrahman Day, Matthew C. Wong et autres

Abstract Young-onset rectal cancer (YORC, <50 years) incidence is rising, representing 20% of colorectal cancers, yet underlying mechanisms driving this epidemic remain unclear. The tumoral microbiome has emerged as a critical modulator of colorectal cancer pathogenesis, affecting tumor growth, inflammation, metastasis, and …

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Abstract PR009: Bugs in Space: Spatial Analysis of the Immune-Microbial Axis in Rectal Cancer Reveals a Unique Interface in Young Onset Rectal Cancers

Ryan B. Morgan, Reed I. Ayabe, Brenda Melendez, Taylor Neilson et autres

Abstract Several hypotheses have been postulated to define the mechanism behind the rising incidence of young onset rectal cancer (YORC). These hypotheses often relate to differences in a population’s exposome and back to a patient’s gut or tumor microbiome. We previously demonstrated …

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ASO Visual Abstract: Clinicopathologic and Molecular Characteristics of High-Grade Appendiceal Mucinous Neoplasms

Ashlee Seldomridge, Michael G. White, Christopher P. Scally, Richard E. Royal et autres

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Supplementary Figures from Intraperitoneal Paclitaxel Is a Safe and Effective Therapeutic Strategy for Treating Mucinous Appendiceal Adenocarcinoma

Ichiaki Ito, Abdelrahman Yousef, Saikat Chowdhury, Princess N. Dickson et autres

Figure S1-S8

Clinicopathologic and Molecular Characteristics of High-Grade Appendiceal Mucinous Neoplasms

Ashlee Seldomridge, Michael G. White, Christopher P. Scally, Richard E. Royal et autres

BACKGROUND: Although 2016 consensus guidelines defined high-grade appendiceal mucinous neoplasms (HAMNs) as a distinct histologic entity, their clinical course and optimal management remain poorly characterized. Comparative data with low-grade appendiceal mucinous neoplasms (LAMNs) are limited. This study aims to detail the clinical …

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Prognosis and treatment response stratification according to loss of proofreading (LOP) POLE variants

Giulia Maddalena, Fadl A. Zeineddine, Saikat Chowdhury, Mohammad A. Zeineddine et autres

Background Only a subset of polymerase epsilon ( POLE ) mutations is associated with hypermutant phenotype; we hypothesized that only loss-of-proofreading (LOP) POLE mutations are associated with favorable immunotherapy response. Methods This retrospective cohort study included a pan-cancer cohort of 69,223 patients …

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Antibodies derived from patient tumors augment response to immune checkpoint blockade in cancer 3582

Manoj Chelvanambi, Monika A. Zelazowska, Somnath Paul, Joshua B. Plummer et autres

Abstract Description Background B-cells and Tertiary Lymphoid Structures (TLS) are associated with response to Immune Checkpoint Blockade (ICB) but their functional role remains unexplored. Here, we evaluate the therapeutic efficacy of tumor-derived antibodies in combination with ICB-based regimen. Methods and Results Tumors …

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