A Decade of Clinical Experience with DARPins in Oncology and Virology: A Systematic Review
Michael T. Stumpp, Vladimir Kirkin, Michael P. Sanderson, Keith M. Dawson et autres
3 citationsmedRxiv
Michael T. Stumpp
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48Publications signalées
1727Citations signalées
1Affiliations récentes
Institutions déclarées
Domaines associés
SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesCancer, Hypoxia, and MetabolismPeptidase Inhibition and AnalysisProtein Structure and Dynamics
Publications récentes
612 Comprehensive biomarker analyses from a phase 1 study reveals marked tumor microenvironment modulation in patients with advanced solid tumors treated with MP0317, a FAP-localized CD40 agonistic DARPin
Jennifer Krieg, Vaia Stavropoulou, Alison Ribeiro, Ana-Maria Florescu et autres
1 citationRegular and Young Investigator Award Abstracts
A phase 1b/2 study evaluating efficacy and safety of MP0250, a designed ankyrin repeat protein (DARPin) simultaneously targeting vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), in combination with bortezomib and dexamethasone, in patients with relapsed or refractory multiple myeloma
Stefan Knop, Monika Szarejko, Norbert Grząśko, Sara Bringhen et autres
9 citationseJHaem
Effect of MP0317, a FAP x CD40 DARPin, on safety profile and tumor-localized CD40 activation in a phase 1 study in patients with advanced solid tumors.
Neeltje Steeghs, Carlos Gomez‐Roca, Iphigénie Korakis, Eelke Gort et autres
6 citationsJournal of Clinical Oncology
The Designed Ankyrin Repeat Protein Antiviral Ensovibep for Nonhospitalized Patients With Coronavirus Disease 2019: Results From EMPATHY, a Randomized, Placebo-Controlled Phase 2 Study
Jeff Kingsley, Nagalingeswaran Kumarasamy, Luis Abrishamian, Marc J. M. Bonten et autres
3 citationsOpen Forum Infectious Diseases
Viral and Host Factors Are Associated With Mortality in Hospitalized Patients With COVID-19
Neil R. Aggarwal, Jacquie Nordwall, Dominique L. Braun, Lucy Chung et autres
16 citationsClinical Infectious Diseases
Effect of Neutralizing Monoclonal Antibody Treatment on Early Trajectories of Virologic and Immunologic Biomarkers in Patients Hospitalized With COVID-19
Tomas Ø. Jensen, Greg Grandits, Mamta K. Jain, Thomas A. Murray et autres
4 citationsThe Journal of Infectious Diseases
Ensovibep, a SARS‐CoV‐2 antiviral designed ankyrin repeat protein, is safe and well tolerated in healthy volunteers: Results of a first‐in‐human, ascending single‐dose Phase 1 study
Nina Stojcheva, Stacy Gladman, Marianne Soergel, Christof Zitt et autres
6 citationsBritish Journal of Clinical Pharmacology
Supplementary Materials, Table 1-6, Figures 1-10 from Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size
Christian Zahnd, Martin Kawe, Michael T. Stumpp, Christine de Pasquale et autres
0 citations
Supplementary Materials, Table 1-6, Figures 1-10 from Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size
Christian Zahnd, Martin Kawe, Michael T. Stumpp, Christine de Pasquale et autres
0 citations
Data from Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size
Christian Zahnd, Martin Kawe, Michael T. Stumpp, Christine de Pasquale et autres
0 citations
Data from Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size
Christian Zahnd, Martin Kawe, Michael T. Stumpp, Christine de Pasquale et autres
0 citations
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