Monica Matchado

Endoscopic healing in pediatric IBD perpetuates a persistent signature defined by Th17 cells with molecular and microbial drivers of disease

Kolja Siebert, Tim Faro, Nikolai Köhler, Hannes Hölz et autres

Endoscopic healing (EH) is the major long-term treatment target for inflammatory bowel diseases (IBDs), mainly achieved by immune-suppressive therapies. However, the chronic and relapsing nature of the disease indicates a lifelong persistence of unknown tissue-associated IBD residues. Based on longitudinally collected gastrointestinal …

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Persistent desmoglein-1 downregulation and periostin accumulation in histologic remission of eosinophilic esophagitis

Hannes Hoelz, Tim Faro, Marie-Luise Frank, Ignasi Forné et autres

BACKGROUND: Patients with eosinophilic esophagitis (EoE) require long-lasting resolution of inflammation to prevent fibrostenosis and dysphagia. However, the dissociation between symptoms and histologic improvement suggests persistent molecular drivers despite histologic remission. OBJECTIVE: We characterized persisting molecular alterations in pediatric patients with EoE …

de, pl (code pays fourni par la source)

785 EXCLUSIVE ENTERAL NUTRITION INITIATES PROTECTIVE FUNCTIONS IN THE GUT MICROBIOTA AND METABOLOME TO INDUCE REMISSION IN PEDIATRIC CROHN'S DISEASE

Deborah Häcker, Kolja Siebert, Amira Metwaly, Hannes Hölz et autres

Sa1639: EXCLUSIVE ENTERAL NUTRITION DRIVES PROTECTIVE MICROBIOME MODULATION IN PEDIATRIC CROHN'S DISEASE

Deborah Häcker, Kolja Siebert, Amira Metwaly, Hannes Hölz et autres