2026
article
OpenAlex
Kelsey Lolatte, Annika Hess, Michael Willmann, Maja Strunk et autres
Different immune cell populations influence the severity of cardiac inflammation after myocardial infarction (MI), which predicts subsequent heart failure. Concurrent neuroinflammation after MI may contribute to heightened risk of cognitive impairment, but the underlying mechanisms remain unclear. We characterized the role of …
de
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2025
article
OpenAlex
Johanna Diekmann, Tobias König, Annika Hess, Carolin Zwadlo et autres
Acute myocardial infarction (AMI) triggers an inflammatory response, which is a determinant of subsequent healing. We speculated that C-X-C motif chemokine receptor 4 (CXCR4) upregulation early after AMI predicts left ventricular (LV) remodeling and cardiac structural functional outcome. Methods: In total, 49 …
de
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2025
article
OpenAlex
Desiree Weiberg, Laura Muana Wilhelm, Tim Felgenhauer, Tobias L. Roß et autres
Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease marked by fibrosis, strictures, and a high risk for developing cholangiocarcinoma (CCC). Recognition of CCC in PSC remains a diagnostic challenge. PET/CT using fibroblast activation protein inhibitors (FAPI) has emerged as a promising …
de
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Accès ouvert
2025
article
OpenAlex
Thomas Wanek, Mari Teuter, Asha Balakrishnan, Tobias L. Roß et autres
Purpose The liver-brain axis regulates metabolic homeostasis, with glucose metabolism playing a key role. Liver dysfunction, such as fibrosis, may impact brain metabolism and consequently, brain function. Positron emission tomography (PET) imaging provides a non-invasive approach to study glucose metabolism in both …
at, de
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2025
article
OpenAlex
Thorsten Derlin, Jasmin Sarah Hanke, Rudolf Alexander Werner, Sibylle Ilse Ziegler et autres
Clinical molecular imaging with PET has an evolving role in the diagnosis and treatment of left ventricular assist device (LVAD)–specific infection. We analyzed the added value of parametric whole-body [18F]FDG PET images for the multifaceted assessment of local inflammatory response to infection …
de
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Accès ouvert
2025
preprint
OpenAlex
Sara Ryding, Tobias L. Roß, Marcel Klaassen
High pathogenicity avian influenza (HPAI) has caused widespread sickness and mortality in poultry and wildlife, especially since the emergence of a novel H5 virus belonging to clade 2.3.4.4b in 2021. The ongoing panzootic caused by this lineage has infected an unprecedented diversity …
au
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2025
article
OpenAlex
Thorsten Derlin, Dennis Kleine-Döpke, Lavinia Neubert, Tobias L. Roß et autres
We aimed to evaluate the feasibility of [18F]flurpiridaz PET/CT for localization of parathyroid adenomas in patients with primary hyperparathyroidism (pHPT). Methods: Data for 11 patients with pHPT undergoing dual-time-point [18F]flurpiridaz PET/CT for localization of hyperfunctioning parathyroid glands were retrospectively analyzed. PET/CT findings …
de
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Accès ouvert
2025
article
OpenAlex
Mari Teuter, Yongfeng Hu, Tobias L. Roß, Kelsey Lolatte et autres
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, globally. There is a need for novel biomarkers for early detection and novel, effective targeted therapies. Molecular imaging can faithfully visualize, characterize and quantify specific relevant biological processes. We performed longitudinal dedicated …
de
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Accès ouvert
2025
article
OpenAlex
Thorsten Derlin, Liam Widjaja, Nina Natascha Harke, Christoph P. Czerner et autres
Our objective was to determine the feasibility, diagnostic performance, and predictive value of 99mTc-MIP-1404 SPECT in patients undergoing baseline staging and assessment of eligibility for prostate-specific membrane antigen (PSMA)–targeted radiopharmaceutical therapy (RPT) for metastatic castration-resistant prostate cancer. Methods: Data of 46 patients …
de
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Accès ouvert
2024
article
OpenAlex
Marion Bankstahl, Ina Jahreis, Bettina Wolf, Tobias L. Roß et autres
The serotonergic system has shown to be altered during epileptogenesis and in chronic epilepsy, making selective serotonin reuptake inhibitors interesting candidates for antiepileptogenic therapy. In this study, we aimed to evaluate disease-modifying effects of fluoxetine during experimental epileptogenesis. Status epilepticus (SE) was …
de, es
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2024
article
OpenAlex
Nina Natascha Harke, Christian Fuhrmann, Christoph P. Czerner, Frank Rudolf et autres
PURPOSE: Prostate-specific membrane antigen (PSMA)-targeted radioguided surgery (RGS) has gained increased interest in prostate cancer (PCa). This analysis aims to evaluate the feasibility, safety, and limitations of RGS with a novel drop-in gamma probe in primary PCa. PATIENTS AND METHODS: The data …
de
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2024
article
OpenAlex
Mark H.P. Strunk, Maday Fernández‐Mayola, Annika Hess, S. Al-Bazaz et autres
Abstract Objectives Myocardial infarction evokes inflammation and activation of quiescent cardiac fibroblasts, leading to heart failure progression. We hypothesized that targeted molecular imaging of fibroblast activation protein (FAP) on activated fibroblasts could predict subsequent remodeling and monitor fibroblast response to anti-inflammatory therapy. …
de
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