Pnina Boer

Overproduction Disease in Man due to Enzyme Feedback Resistance Mutation

Oded Sperling, Pnina Boer, Sara Brosh, Esther Zoref et autres

Physiologically superactive phosphoribosylpyrophosphate (PRPP) synthetase, due to feedback resistance mutation, was found in a family with excessive purine production, gout and uric acid lithiasis. The superactivity of the mutant enzyme was manifest in the propositus' erythrocytes and cultured fibroblasts, in increased generation, …

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Uric Acid Lithiasis Associated with Excessive Purine Production Due to Mutant Phosphoribosylpyrophosphate Synthetase

Oded Sperling, S. Persky-Brosh, Pnina Boer, André de Vries

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AN-446 a Bi-Functional Codrug of the Histone Deacetylase Inhibitor Valproic Acid Linked to the Antiviral Agent Acyclovir as a Targeted Anti-Cancer Agent

E. Nissim-Bardugo, Michal Weitman, S. Sochotnik, Gili Berkovitch-Luria et autres

Abstract 77: The HDAC inhibitory prodrug AN-7 reduces the toxicity of doxorubicin, anti-Her2 and radiation while augmenting their anticancer efficacy

Nataly Tarasenko, Suzanne M. Cutts, Yoav Lipsky, Pnina Boer et autres

Abstract The histone deacetylase inhibitor (HDACI) butyroyloxymethyl diethylphosphate (AN-7), has been shown to possess anticancer activity in vitro and in vivo and to act in synergy with doxorubicin (Dox) in killing cancer cells while attenuating Dox-induced cardiotoxicity (Rephaeli et al., 2007). In …

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The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity

Nataly Tarasenko, Gania Kessler‐Icekson, Pnina Boer, Aida Inbal et autres

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De novo Synthesis of Purine Nucleotides in Human Blood Platelets

Zohara Jerushalmy, M. Patya, Pnina Boer, Oded Sperling

Human blood platelets were found to carry the complete pathway of de novo purine nucleotide synthesis. The rate of purine synthesis was gauged by the rate of incorporation of precursor (14C)formate into purines. The effect on formate incorporation of several compounds known …

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Pentose Shunt, Phosphoribosylpyrophosphate Generation and Purine-Phosphoribosyltransferases in Erythrocytes of Patients with Polycythemia vera

Oded Sperling, Pnina Boer, Sara Brosh, Ella Elazar et autres

Erythrocytes of patients with polycythemia vera exhibited increased activity of oxidative pentose shunt, accelerated generation of phosphoribosylpyrophosphate, increased incorporation of 14C-adenine into nucleotides, and increased activity and thermostability of adenine-phosphoribosyltransferase. These abnormalities are attributed to age dependency of the pathways concerned and …

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Bifunctional Prodrugs of Acyclovir and Histone Deacetylase Inhibitors Selective Affect Epstein-Barr Virus Positive Human Lymphoma Cell Lines

Pnina Boer, Carmit Alexenberg, Nataly Tarasenko, E. Nissim-Bardugo et autres

Contents, Vol. 35, 1983

James Goya Heaf, Finn Jørgensen, Lars Peter Nielsen, Amir H. Tejani et autres

Modulation of Glycogen Phosphorylase Activity Affects 5‐Phosphoribosyl‐1‐pyrophosphate Availability in Rat Hepatocyte Cultures

Pnina Boer, Oded Sperling

Abstract For Abstract see ChemInform Abstract in Full Text.

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Modulation of Glycogen Phosphorylase Activity Affects 5‐Phosphoribosyl‐1‐Pyrophosphate Availability in Rat Hepatocyte Cultures

Pnina Boer, Oded Sperling

The effect of modulation of the rate of glycogenolysis on the availability of 5-phosphoribosyl-1-pyrophosphate (PRPP) was investigated in rat hepatocyte cultures. Dibutyryl cyclic AMP (dbcAMP), forskolin and glucagon, activating glycogen phosphorylase through activation of protein kinase A (PKA), were found to raise …

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Purine nucleotide metabolism in cultured neurons and astroglia from HPRT-deficient knockout mice.

E. Zoref‐Shani, Pnina Boer, Sara Brosh, Dori Pelled et autres

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