Larissa S. Moniz

Surgical capacity in ophthalmology: the unmet need for sustainable solutions

Roxane J. Hillier, Andrew Chang, Amanda Matse-Orere, Christian Bindesbøll et autres

The increasing prevalence of eye diseases is placing significant pressure on surgical and procedure-based ophthalmology services worldwide. Delays in surgical care can lead to poorer patient outcomes and reduced treatment efficacy, highlighting the urgent need for healthcare systems to address these challenges. …

gb, au, ch, ca (code pays fourni par la source)

Physical, Psychosocial, and Practical Burden of Patients Receiving Care for Age-Related Macular Degeneration in Canada: A Mixed-Methods Qualitative Study

Pradeepa Yoganathan, Bernard Hurley, Andrew Merkur, Chad Andrews et autres

Purpose: Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss. Documentation of the disease's description and treatment experience of Canadian patients is limited but of interest given the aging population and resultant implications for healthcare systems. A mixed-methods study …

ca, us, gb, no (code pays fourni par la source)

Patient perspectives on accessing eye-related healthcare from rural communities

Prethy Rao, Rajeev S. Ramchandran, Kira Baldonado, Stephan Hüsler et autres

Rural populations frequently encounter substantial barriers to accessing ophthalmology care, often resulting in delayed diagnosis and less effective disease management [ 1 , 2 ]. This patient- and provider-centred multinational study explored the challenges patients and caregivers encounter and proposed improvements for …

us, nz, ca, ch, au (code pays fourni par la source)

Impact of inherited retinal diseases on Canadian patients and families: a mixed-methods study

Imaan Zera Kherani, Chad Andrews, Jennifer Pereira, Larissa S. Moniz et autres

ca (code pays fourni par la source)

The Impact of Inherited Retinal Diseases in the United States of America (US) and Canada from a Cost-of-Illness Perspective

Jennifer Gong, Simone Cheung, Alivia Fasso-Opie, Orla Galvin et autres

OBJECTIVE: To estimate the annual cost of inherited retinal diseases (IRDs) in the United States of America (US) and Canada from a societal perspective - including costs to the health system, individual and family productivity costs, lost wellbeing and other societal economic …

au, ca, us, ch (code pays fourni par la source)

NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells

Ralitsa R. Madsen, James Longden, Rachel Knox, Xavier Robin et autres

Activating PIK3CA mutations are known 'drivers' of human cancer and developmental overgrowth syndromes. We recently demonstrated that the 'hotspot' PIK3CAH1047R variant exerts unexpected allele dose-dependent effects on stemness in human pluripotent stem cells (hPSCs). In this study, we combine high-depth transcriptomics, total …

gb, dk, de (code pays fourni par la source)

Author Reply to Peer Reviews of NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells

Robert K. Semple, Bart Vanhaesebroeck, Rune Linding, Neil O. Carragher et autres

NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CA H1047R homozygosity in pluripotent stem cells

Ralitsa R. Madsen, James Longden, Rachel Knox, Xavier Robin et autres

Abstract Activating PIK3CA mutations are known “drivers” of human cancer and developmental overgrowth syndromes. We recently demonstrated that the “hotspot” PIK3CA H1047R variant exerts unexpected allele dose-dependent effects on stemness in human pluripotent stem cells (hPSCs). In the present study, we combine …

gb, in, dk, de (code pays fourni par la source)

National implementation of multi‐parametric magnetic resonance imaging for prostate cancer detection – recommendations from a UK consensus meeting

Mrishta Brizmohun Appayya, Jim Adshead, Hashim U. Ahmed, Clare Allen et autres

OBJECTIVES: To identify areas of agreement and disagreement in the implementation of multi-parametric magnetic resonance imaging (mpMRI) of the prostate in the diagnostic pathway. MATERIALS AND METHODS: Fifteen UK experts in prostate mpMRI and/or prostate cancer management across the UK (involving nine …

gb (code pays fourni par la source)

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

Inma M. Berenjeno, Roberto Piñeiro, Sandra D. Castillo, Wayne Pearce et autres

Abstract Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of mutant PIK3CA during early stages of malignancy is unknown. Using a mouse model to activate the Pik3ca H1047R hotspot mutation …

gb, es, au (code pays fourni par la source)

Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate

Larissa S. Moniz, Silvia Šurinová, Essam Ghazaly, Lorena Gonzalez Velasco et autres

Abstract To identify novel effectors and processes regulated by PI3K pathway activation, we performed an unbiased phosphoproteomic screen comparing two common events of PI3K deregulation in cancer: oncogenic Pik3ca mutation (Pik3caH1047R) and deletion of Pten. Using mouse embryonic fibroblast (MEF) models that …

gb (code pays fourni par la source)

Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice

Samira Alliouachene, Benoît Bilanges, Claire Chaussade, Wayne Pearce et autres

AIMS/HYPOTHESIS: While the class I phosphoinositide 3-kinases (PI3Ks) are well-documented positive regulators of metabolism, the involvement of class II PI3K isoforms (PI3K-C2α, -C2β and -C2γ) in metabolic regulation is just emerging. Organismal inactivation of PI3K-C2β increases insulin signalling and sensitivity, whereas PI3K-C2γ …

gb, fr (code pays fourni par la source)