Alec D. McCarthy

Calcium Hydroxylapatite–Carboxymethylcellulose Gel Embolization in a Simulated Microvascular Environment: Occlusion, Retrograde Flow Dynamics, and Enzymatic Recanalization

Danny J. Soares, Jasmine Wu, Alec D. McCarthy

BACKGROUND: The microvascular behavior of calcium hydroxylapatite-carboxymethylcellulose (CaHA-CMC) fillers during arterial embolization remains incompletely characterized, particularly with respect to distal occlusive potential, bolus size effects, retrograde dissemination dynamics, and recanalization strategies. OBJECTIVES: To evaluate the dispersal of differentially dilute CaHA-CMC in a …

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Regeneration of an Extracellular Matrix Ecosystem Following Subcutaneous Injection With Different Radiesse Dilutions: A Histologic and Ultrasound Study

Kate Goldie, Gabriela Casabona, Niamh Corduff, Alec D. McCarthy et autres

ABSTRACT Background Calcium hydroxylapatite‐carboxymethylcellulose (CaHA‐CMC) stimulates neocollagenesis across a range of dilutions; however, the magnitude and temporal profile of this bioregenerative response have not yet been comprehensively examined. Objective To assess collagen, elastin, and proteoglycan expression, as well as elastosis, microcirculation, and …

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Calcium Hydroxylapatite‐Carboxymethylcellulose as a Treatment for Forearm Dermatoporosis: A Prospective, Delayed‐Start, Contralateral Case Series

Ada Trindade de Almeida, Maria Cortez de Sousa Marins Barbosa, Alexandre Michalany, Alec D. McCarthy

BACKGROUND: Dermatoporosis is a chronic cutaneous fragility syndrome marked by dermal thinning, collagen loss, and recurrent purpuric lesions. Effective treatments remain limited. Calcium hydroxylapatite-carboxymethylcellulose (CaHA-CMC) is a regenerative biostimulator with demonstrated skin extracellular matrix-restorative effects, but its usefulness in forearm dermatoporosis has …

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3D hierarchically aligned nanofiber scaffolds promote cell migration for tissue regeneration

Haiyan Pan, Jiebing Zhao, Ruyi Fan, Alec D. McCarthy et autres

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Rising Public Interest in Weight Loss Medications and Growing Awareness of Their Aesthetic Sequelae: An Infodemiologic Google Trends Analysis and Clinical Diagnostic Patterning

Alec D. McCarthy, Kay Durairaj, Jacob Linneman‐Heath, Dusan Sajic et autres

BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have gained rapid popularity for both medical and consumer-directed weight loss. This growth has been accompanied by increased public discussion regarding facial aesthetic changes, commonly referred to as "Ozempic face," characterized by volume depletion and …

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Calcium Hydroxylapatite

Alec D. McCarthy, Viviana Perico, Shino Bay Aguilera, Alessandro Gennai et autres

In aesthetic medicine, the innovative blend of CaHA with other advanced methods marks a specialized and contemporary strategy for addressing facial aging. Because of their ability to simultaneously address various aspects of aging, these integrated treatments yield more comprehensive and enhanced results. …

Calcium Hydroxylapatite

Kate Goldie, Niamh Corduff, Alec D. McCarthy, Jani van Loghem et autres

Calcium hydroxyapatite (CaHA) is a naturally occurring mineral found in stone as well as in the bones and teeth of animals, including humans. Primarily composed of calcium and phosphate, CaHA represents the active component of Radiesse, a soft-tissue filler that will be …

Exploring the Rheology and Clinical Potential of Calcium Hydroxylapatite‐Hyaluronic Acid Hybrids

Ewelina Kaczuba, Nabil Fakih‐Gomez, Jonathan A. Kadouch, Rolf Bartsch et autres

ABSTRACT Background Combining calcium hydroxylapatite‐carboxymethylcellulose (CaHA‐CMC) with hyaluronic acid (HA) products using Cohesive Polydensified Matrix (CPM) technology leverages the volumizing and hydrating effects of HA and draws upon the regenerative properties of CaHA‐CMC, providing a potentially synergistic approach in aesthetic filling treatments. …

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Microfocused Ultrasound With Visualization in Skin Quality: A Narrative Review

Tatjana Pavicic, Jeremy B. Green, Jeyoung Park, Gabriela Casabona et autres

BACKGROUND: Skin quality is a multidimensional concept encompassing four emergent perceptual categories (EPCs): firmness, surface evenness, tone evenness, and glow. Microfocused Ultrasound with Visualization (MFU-V; Ulthera System) is a non-invasive device FDA-cleared for lifting and tightening of the skin in specific areas. …

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Microvascular Insights Into Hyaluronic Acid Filler Dispersal Within an Artificial Model of Arterial Embolism

Danny J. Soares, Robyn D. Siperstein, Thomas J. Kean, Alec D. McCarthy

BACKGROUND: Hyaluronic acid (HA) filler-induced vascular occlusion is a serious complication in aesthetic medicine, yet the microvascular behavior of HA gels under physiologically relevant flow conditions remains poorly characterized. OBJECTIVES: To evaluate the embolic fragmentation, dispersal, and occlusive behavior of 5 commercially …

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Reduction of Early‐Onset Calcium Hydroxylapatite‐Carboxymethylcellulose Accumulations Using Focused Mechanical Vibration: An Experimental Model and Case Report

Jaya Krishna Rose Batra, Brandi Gregge, Alec D. McCarthy, William Gregory Chernoff et autres

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Comparative Ultrasound Visualization Analysis Between Ultherapy® and Ultherapy PRIME and Survey and Clinical Case Results from the Ultherapy PRIME Early Experience Program

Jennifer M. Levine, Alec D. McCarthy, Pavicic, Jeremy B. Green

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